Výsledky vyhledávání - "Atsuko, Tsuchida"

Cyclic GMP-dependent protein kinase II is a molecular switch from proliferation to hypertrophic differentiation of chondrocytes

Autor: Kajuro Komeda, Atsuko Tsuchida, Hiroshi Kawaguchi, Hirotaka Chikuda, Takashi Shimoaka, Toru Ogasawara, Satoru Kamekura, Toshiyuki Ikeda, Norihide Yokoi, Hirotaka Kawano, Kazuto Hoshi, Fumitaka Kugimiya, Kozo Nakamura, Ung-il Chung

Publikováno v: Genes & Development. 18:2418-2429

The Komeda miniature rat Ishikawa (KMI) is a naturally occurring mutant caused by an autosomal recessive mutation mri, which exhibits longitudinal growth retardation. Here we identified the mri mutation as a deletion in the rat gene encoding cGMP-dep

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1a55c60d627edc8750af88763426bb2
https://doi.org/10.1101/gad.1224204

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The Mechanisms by Which Both Heterozygous Peroxisome Proliferator-activated Receptor γ (PPARγ) Deficiency and PPARγ Agonist Improve Insulin Resistance

Autor: Toshimasa Yamauchi, Naoto Kubota, Ryozo Nagai, Kajuro Komeda, Yasuo Terauchi, Kazuyuki Tobe, Yasuo Akanuma, Satoshi Kimura, Junji Kamon, Koji Murakami, Hiroshi Miki, Tomohiro Ide, Takashi Kadowaki, Atsuko Tsuchida, Hironori Waki, Kiyoto Motojima

Publikováno v: Journal of Biological Chemistry. 276:41245-41254

Peroxisome proliferator-activated receptor (PPAR) gamma is a ligand-activated transcription factor and a member of the nuclear hormone receptor superfamily that is thought to be the master regulator of fat storage; however, the relationship between P

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ff8122cadf39aae2fe22524f0f703c4
https://doi.org/10.1074/jbc.m103241200

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Inhibition of RXR and PPARγ ameliorates diet-induced obesity and type 2 diabetes

Publikováno v: Journal of Clinical Investigation. 108:1001-1013

PPARgamma is a ligand-activated transcription factor and functions as a heterodimer with a retinoid X receptor (RXR). Supraphysiological activation of PPARgamma by thiazolidinediones can reduce insulin resistance and hyperglycemia in type 2 diabetes,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b14e17b7ae716d1827dce85c2d6bfe3b
https://doi.org/10.1172/jci12864

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Essential Role of Insulin Receptor Substrate 1 (IRS-1) and IRS-2 in Adipocyte Differentiation

Autor: Junji Matsui, Yasuo Akanuma, Ryo Suzuki, Yasuo Terauchi, Atsuko Tsuchida, Takashi Kadowaki, Ryozo Nagai, Junji Kamon, Hiroshi Miki, Satoshi Kimura, Kajuro Komeda, Yasushi Kaburagi, Toshimasa Yamauchi, Naoto Kubota, Kazuyuki Tobe

Publikováno v: Molecular and Cellular Biology. 21:2521-2532

To investigate the role of insulin receptor substrate 1 (IRS-1) and IRS-2, the two ubiquitously expressed IRS proteins, in adipocyte differentiation, we established embryonic fibroblast cells with four different genotypes, i.e., wild-type, IRS-1 defi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3886de1d3721de2e031ea37efba6cbd0
https://doi.org/10.1128/mcb.21.7.2521-2532.2001

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Usefulness of SEPARAX-SP membrane for supporting medium in cellulose acetate membrane isoelectric focusing

Autor: Nobuo Hiratsuka, Junko Inoue, Nobutaka Yamaguchi, Atsuko Tsuchida, Kiyoko Shiba, Shiro Iijima, Saeko Shimura, Miyako Kimura

Publikováno v: SEIBUTSU BUTSURI KAGAKU. 44:39-42

SEPARAX-SP membrane is used generally as supporting medium for serum protein fractionation in many clinical laboratories, but it has not been used for isoelectric focusing (IEF). Although the exclusive cellulose acetate membrane for IEF is a SEPARAX-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::032a499e24f555eac98fb088f495c79a
https://doi.org/10.2198/sbk.44.39

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Phenotypic characterization of the Komeda miniature rat Ishikawa, an animal model of dwarfism caused by a mutation in Prkg2

Autor: Atsuko, Tsuchida, Norihide, Yokoi, Misako, Namae, Masanori, Fuse, Taku, Masuyama, Masashi, Sasaki, Shoji, Kawazu, Kajuro, Komeda

Publikováno v: Comparative medicine. 58(6)

The Komeda miniature rat Ishikawa (KMI) is a spontaneous animal model of dwarfism caused by a mutation in Prkg2, which encodes cGMP-dependent protein kinase type II (cGKII). This strain has been maintained as a segregating inbred strain for the mutat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e423bc9b6214a6c9cde0dcb05025aeb4
https://pubmed.ncbi.nlm.nih.gov/19149413

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Sex difference and possible relationship to microvascular complications of serum prorenin levels in type 2 diabetic patients, measured by a novel antibody-activating direct enzyme kinetic assay

Autor: Yasuo Imai, Hiroshi Tanaka, Yuichi Ishida, Shinya Minagawa, Atsuko Tsuchida, Chika Ihara, Eiji Ohmura, Fumiaki Suzuki, Masako Yazawa, Shoji Kawazu, Daiya Hosaka

Publikováno v: Journal of diabetes and its complications. 18(5)

Prorenin, a precursor of renin, was measured in sera from normal subjects and type 2 diabetic patients, using a newly developed antibody-activating direct enzyme kinetic assay. Levels of prorenin were examined in relationship to diabetic microangiopa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ca9f3f864361c4cf3a0d6914352dfef
https://pubmed.ncbi.nlm.nih.gov/15337501

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Increased insulin sensitivity despite lipodystrophy in Crebbp heterozygous mice

Autor: Ken Ichi Yamamura, Yukari Date, Masamitsu Nakazato, Takeyori Saheki, Hiroshi Miki, Junji Kamon, Kajuro Komeda, Hironori Waki, Yasuo Akanuma, Yuichi Oike, Ryozo Nagai, Takeshi Naitoh, Toshimasa Yamauchi, Takashi Kadowaki, Satoshi Kimura, Meng Xian Li, Atsuko Tsuchida

Publikováno v: Nature genetics. 30(2)

The CBP protein (cAMP response element binding protein (CREB) binding protein) is a co-activator for several transcription factors with a wide range of important biological functions, such as sterol regulatory element binding proteins (SREBPs), CCAAT

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3757aee4025f9e450cf8edcb2f7612ab
https://pubmed.ncbi.nlm.nih.gov/11818964

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