Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Atsuko, Ochida"'
Autor:
Benjamin Blasco, Soojin Jang, Hiroki Terauchi, Naoki Kobayashi, Shuichi Suzuki, Yuichiro Akao, Atsuko Ochida, Nao Morishita, Terufumi Takagi, Hiroyuki Nagamiya, Yamato Suzuki, Toshiaki Watanabe, Hyunjung Lee, Sol Lee, David Shum, Ahreum Cho, Dahae Koh, Soonju Park, Honggun Lee, Kideok Kim, Henni-Karoliina Ropponen, Renata Maria Augusto da Costa, Steven Dunn, Sunil Ghosh, Peter Sjö, Laura J.V. Piddock
Publikováno v:
EBioMedicine, Vol 102, Iss , Pp 105073- (2024)
Summary: Background: The current pipeline for new antibiotics fails to fully address the significant threat posed by drug-resistant Gram-negative bacteria that have been identified by the World Health Organization (WHO) as a global health priority. N
Externí odkaz:
https://doaj.org/article/eaf98873ad5c42ceacfa2d3e86721587
Autor:
Taisuke, Tawaraishi, Atsuko, Ochida, Yuichiro, Akao, Sachiko, Itono, Masahiro, Kamaura, Thamina, Akther, Mitsuyuki, Shimada, Stacie, Canan, Sanjoy, Chowdhury, Yafeng, Cao, Kevin, Condroski, Ola, Engkvist, Amanda, Francisco, Sunil, Ghosh, Rina, Kaki, John M, Kelly, Chiaki, Kimura, Thierry, Kogej, Kazuya, Nagaoka, Akira, Naito, Garry, Pairaudeau, Constantin, Radu, Ieuan, Roberts, David, Shum, Nao-Aki, Watanabe, Huanxu, Xie, Shuji, Yonezawa, Osamu, Yoshida, Ryu, Yoshida, Charles, Mowbray, Benjamin, Perry
Publikováno v:
Journal of medicinal chemistry.
Probing multiple proprietary pharmaceutical libraries in parallel via virtual screening allowed rapid expansion of the structure-activity relationship (SAR) around hit compounds with moderate efficacy against
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::098120064a818c49ef6eba16a4ffb203
https://pubmed.ncbi.nlm.nih.gov/36607408
https://pubmed.ncbi.nlm.nih.gov/36607408
Autor:
Atsuko Ochida, Masahiro Kamaura, Angelika Sturm, Xue Chen, Karen L. White, Benoît Laleu, Binglin Wang, Benigno Crespo, Yuichiro Akao, Nobuo Cho, Gong Chen, Vicky M. Avery, Sergio Wittlin, Laura M. Sanz, Francis C. K. Chiu, Koen J. Dechering, David M. Shackleford, Kasiram Katneni, Sandra Duffy, Leonardo Lucantoni, Susan A. Charman
Publikováno v:
Journal of Medicinal Chemistry. 64:12582-12602
A phenotypic high-throughput screen allowed discovery of quinazolinone-2-carboxamide derivatives as a novel antimalarial scaffold. Structure-activity relationship studies led to identification of a potent inhibitor 19f, 95-fold more potent than the o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2cf33a3e0cc4d27cbcc8fe60cf19f5e
https://doi.org/10.1021/acs.jmedchem.1c00441
https://doi.org/10.1021/acs.jmedchem.1c00441
Publikováno v:
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. 142(7)
Delivering new medicines to patients suffering from Neglected Tropical Diseases (NTD) is a major challenge. There are various hurdles to be overcome, such as the large number of patients in a large number of different regions, the lack of marketabili
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf730f94cd54b3f265159f642d1fbdec
https://pubmed.ncbi.nlm.nih.gov/35781496
https://pubmed.ncbi.nlm.nih.gov/35781496
Autor:
Vicky M. Avery, Tomas Yeo, Susan A. Charman, David A. Fidock, Anne-Catrin Uhlemann, Sandra Duffy, Sumanta Dey, Sergio Wittlin, Laura M. Sanz, Rafael Victorio Carvalho Guido, Benigno Crespo, Alisje Churchyard, Atsuko Ochida, Jacquin C. Niles, Anna Caroline Campos Aguiar, Yuichiro Akao, Jake Baum, Karen L. White, Leonardo Lucantoni, Josefine Striepen, Masanori Okaniwa, Angelika Sturm, Dhelio Batista Pereira, Akira Shibata, Koen J. Dechering, David M. Shackleford, Sachel Mok, Benoît Laleu
Publikováno v:
ACS
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Prolyl-tRNA synthetase (PRS) is a clinically validated antimalarial target. Screening of a set of PRS ATP-site binders, initially designed for human indications, led to identification of 1-(pyridin-4-yl)pyrrolidin-2-one derivatives representing a nov
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdd99b0f8a80b7cd225661da3769c746
https://doi.org/10.1021/acsinfecdis.1c00020
https://doi.org/10.1021/acsinfecdis.1c00020
Autor:
Atsuko Ochida, Masaya Sawamura
Publikováno v:
ARKIVOC, Vol 2006, Iss 7, Pp 359-369 (2006)
Externí odkaz:
https://doaj.org/article/2eead3f656054048b1f41c41b8c74d66
Autor:
Masanori, Okaniwa, Akira, Shibata, Atsuko, Ochida, Yuichiro, Akao, Karen L, White, David M, Shackleford, Sandra, Duffy, Leonardo, Lucantoni, Sumanta, Dey, Josefine, Striepen, Tomas, Yeo, Sachel, Mok, Anna Caroline C, Aguiar, Angelika, Sturm, Benigno, Crespo, Laura M, Sanz, Alisje, Churchyard, Jake, Baum, Dhelio B, Pereira, Rafael V C, Guido, Koen J, Dechering, Sergio, Wittlin, Anne-Catrin, Uhlemann, David A, Fidock, Jacquin C, Niles, Vicky M, Avery, Susan A, Charman, Benoît, Laleu
Publikováno v:
ACS Infectious Diseases
Prolyl-tRNA synthetase (PRS) is a clinically validated antimalarial target. Screening of a set of PRS ATP-site binders, initially designed for human indications, led to identification of 1-(pyridin-4-yl)pyrrolidin-2-one derivatives representing a nov
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7ab293ce6637b0b78101c78cbc174107
https://pubmed.ncbi.nlm.nih.gov/33929818
https://pubmed.ncbi.nlm.nih.gov/33929818
Autor:
Mark Smith, Atsuko Ochida, Stephanie Kabeche, Thamina Akther, Takashi Ichikawa, Michael J. Pulkoski-Gross, Jumpei Aida, Paul S. Humphries, Ellen Yeh
Publikováno v:
Bioorganicmedicinal chemistry letters. 41
A series of novel thiazole-containing amides were synthesized. A structure-activity relationship study of these compounds led to the identification of potent and selective PfFPPS/GGPPS inhibitors with good in vitro ADME profiles. The most promising c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f589b25651e73127628ffa91a54ecc8
https://pubmed.ncbi.nlm.nih.gov/33766764
https://pubmed.ncbi.nlm.nih.gov/33766764
Autor:
Junya Shirai, Yoshiyuki Fukase, Keiko Koga, Ryoukichi Koyama, Hideyuki Nakagawa, Isaac Hoffman, Bi-Ching Sang, Mitsunori Kono, Toshitake Okui, Satoshi Yamamoto, Yasushi Fujitani, Masaharu Nakayama, Yoshihide Tomata, Robert J. Skene, Kazuko Yonemori, Atsuko Ochida, Masashi Yamasaki, Ayumu Sato
Publikováno v:
Bioorganic & Medicinal Chemistry. 26:721-736
Novel small molecules were synthesized and evaluated as retinoic acid receptor-related orphan receptor-gamma t (RORγt) inverse agonists for the treatment of inflammatory and autoimmune diseases. A hit compound, 1, was discovered by high-throughput s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c0bcec89232f743c17ead49dd6e7d73
https://doi.org/10.1016/j.bmc.2017.12.039
https://doi.org/10.1016/j.bmc.2017.12.039
Autor:
Junya Shirai, Yoshiyuki Fukase, Tetsuji Kawamoto, Mitsunori Kono, Tsuneo Oda, Mikio Shirasaki, Yasushi Fujitani, Hiroyuki Watanabe, Hideyuki Nakagawa, Keiko Uga, Michiko Tawada, Naohiro Taya, Akira Shibata, Takashi Imada, Yoshihide Tomata, Masashi Yamasaki, Tomoya Yukawa, Shoji Fukumoto, Hidekazu Tokuhara, Satoshi Yamamoto, Naoki Ishii, Atsuko Ochida, Yoshihiro Banno
Publikováno v:
Bioorganic & Medicinal Chemistry. 26:470-482
A series of tetrahydroisoquinoline derivatives were designed, synthesized, and evaluated for their potential as novel orally efficacious retinoic acid receptor-related orphan receptor-gamma t (RORγt) inverse agonists for the treatment of Th17-driven
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::525a6e1c5124e88399900d795fac2e06
https://doi.org/10.1016/j.bmc.2017.12.008
https://doi.org/10.1016/j.bmc.2017.12.008