Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Atsuhiro INABA"'
Autor:
Atsuhiro Inaba, Masato Yoshida, Mika Goto, Masashi Yamaguchi, Akira Mori, Hiroyuki Kimura, Tsuneo Yasuma, Haruhiko Makino, Masahiro Oka, Tomohiro Kawamoto, Hisashi Fujita, Atsuo Baba
Publikováno v:
Bioorganic & Medicinal Chemistry. 18:8501-8511
A series of novel tetrahydropyrazolopyrimidine derivatives containing an adamantyl group were synthesized and evaluated as potential calcium-sensing receptor (CaSR) antagonists. After chemical modification of 9a, which was identified as a hit compoun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3725c36885b7ea51b3d03490ec18c4ef
https://doi.org/10.1016/j.bmc.2010.10.035
https://doi.org/10.1016/j.bmc.2010.10.035
Autor:
Atsuhiro Inaba, Hiroshi Takeda, Junichi Azuma, Hiromi Maune, Toshiko Koue, Tsuyoshi Fukuda, Masanori Kubo
Publikováno v:
Drug Metabolism and Pharmacokinetics. 20:55-64
The results of in vitro studies indicated that ARIPIPRAZOLE, a newly developed antipsychotic, is mainly metabolized by the human cytochrome P450 isozymes CYP3A4 and CYP2D6. The objective of the present study was to investigate the influence of itraco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f667f2653d1c4e0bac3eaf2d02966adc
https://doi.org/10.2133/dmpk.20.55
https://doi.org/10.2133/dmpk.20.55
Autor:
Akio Hiyama, Atsuhiro Inaba, Nobuhiko Kowata, Emiko Kamada, Shigeru Furuta, Michael Hall, Nobuyoshi Akagawa, Anne Matthews, Yoshihiro Kawabata, Tadashi Kurimoto
Publikováno v:
British Journal of Clinical Pharmacology. 54:295-303
Aims To identify the cytochrome P450 (CYP) and UDP-glucuronosyltransferase (UGT) isoforms responsible for the formation of the primary metabolite(s) of zaltoprofen, and to predict possible drug interactions by investigating the inhibition of CYP isof
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1b1511ecee7bcf1c3b346ae9287f6d79
https://doi.org/10.1046/j.1365-2125.2002.01649.x
https://doi.org/10.1046/j.1365-2125.2002.01649.x
Autor:
Shuichiro Tsutsumi, Katsuhiro Inada, Atsuhiro Inaba, Megumi Fushimi, Yoshio Esumi, Mitsuyoshi Isaka, Yoshio Karasawa
Publikováno v:
Drug Metabolism and Pharmacokinetics. 14:32-41
The absorption, distribution and metabolism of bromfenac sodium were investigated after single or repeated application of 14C-bromfenac sodium ophthalmic solution to both eyes of male albino rabbits at a dose of 0.1 mg/animal (0.05 mg/50 μl/eye). 1.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d935f5112b4e380acf0868c0ae77304a
https://doi.org/10.2133/dmpk.14.32
https://doi.org/10.2133/dmpk.14.32
Autor:
Mannen MISHIMA, Masataka UEDA, Atsushi TAKAO, Atsuhiro INABA, Keiko KAMIYA, Hiromi MORIKI, Hironobu KIRIYA, Manami TAGUCHI, Teruaki YUZURIHA
Publikováno v:
Drug Metabolism and Pharmacokinetics. 14:214-224
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::61a7469184c97737189dac958a50274b
https://doi.org/10.2133/dmpk.14.214
https://doi.org/10.2133/dmpk.14.214
Autor:
Atsushi Takao, Atsuhiro Inaba, Masataka Ueda, Hiromi Moriki, Mannen Mishima, Teruaki Yuzuriha, Manami Taguchi, Keiko Kamiya, Hironobu Kiriya
Publikováno v:
Drug Metabolism and Pharmacokinetics. 14:201-213
Blood and plasma concentration-time profile, distribution, metabolism, excretion of radioactivity after a single intravenous administration of 14C-Flecainide acetate at a dose of 2 mg/kg to dogs, and in vitro and in vivo plasma protein binding were s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::abc2f47da7694c6d6aced91156598207
https://doi.org/10.2133/dmpk.14.201
https://doi.org/10.2133/dmpk.14.201
Autor:
Atsuhiro Inaba, Keiji Masaki, Kiyomi Shirakawa, Shin-ichi Ninomiya, Masatoshi Tomida, Yoshio Esumi, Toshiyuki Mashiko, Ryoji Konishi
Publikováno v:
Drug Metabolism and Pharmacokinetics. 11:81-92
The absorption, distribution, metabolism and excretion of MC903 were investigated in rats after a single dermal application in 5 μg/100 mg ointment/body using an occlusive dressing technique. 1. The radioactivity level in the plasma reached a Cmax a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::80219e3d3f0131af4408f8c5d52f8f18
https://doi.org/10.2133/dmpk.11.81
https://doi.org/10.2133/dmpk.11.81
Autor:
Masatoshi Tomida, Atsuhiro Inaba, Toshiyuki Mashiko, Shin-ichi Ninomiya, Ryoji Konishi, Keiji Masaki, Kiyomi Shirakawa, Yoshio Esumi
Publikováno v:
Drug Metabolism and Pharmacokinetics. 11:57-80
The absorption, distribution, metabolism, excretion, transfer into the fetus and milk of MC903 were investigated in rats after a single subcutaneous administration (2 μg/kg). 1. The level of radioactivity in the plasma reached a Cmax at 1 hr, the re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a867fe8a222672fe0df5a579eed6ee59
https://doi.org/10.2133/dmpk.11.57
https://doi.org/10.2133/dmpk.11.57
Autor:
Masatoshi Tomida, Atsuhiro Inaba, Shin-ichi Ninomiya, Ryoji Konishi, Keiji Masaki, Kiyomi Shirakawa, Yoshio Esumi, Toshiyuki Mashiko
Publikováno v:
Drug Metabolism and Pharmacokinetics. 11:93-105
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5fddcc8d61f2669fc76f7a908de7d8e9
https://doi.org/10.2133/dmpk.11.93
https://doi.org/10.2133/dmpk.11.93
Autor:
Yuji Okada, Yoshio Esumi, Sadao Tsuji, Toshiro Kamishiro, Matuo Takaichi, Atsuhiro Inaba, Masayuki Ichikawa
Publikováno v:
Drug Metabolism and Pharmacokinetics. 9:715-734
The metabolism of NC-1300-O-3, a new proton pump inhibitor with potent cytoprotective effect on the gastric mucosa, was examined after oral administration of 14C-NC-1300-O-3 in rats and dogs. 1. Following metabolites were found to be present in rat p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::84ecf9606bc7d1c57c5f61b16323a394
https://doi.org/10.2133/dmpk.9.715
https://doi.org/10.2133/dmpk.9.715