Zobrazeno 1 - 10
of 121
pro vyhledávání: '"Atsuhiko T. Naito"'
Autor:
Hideki Yasutake, Jong-Kook Lee, Akihito Hashimoto, Kiyoshi Masuyama, Jun Li, Yuki Kuramoto, Shuichiro Higo, Shungo Hikoso, Kyoko Hidaka, Atsuhiko T. Naito, Shigeru Miyagawa, Yoshiki Sawa, Issei Komuro, Yasushi Sakata
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract Duchenne muscular dystrophy (DMD) is characterized by progressive muscle degeneration accompanied by dilated cardiomyopathy. Recently, abnormality of yes-associated protein (YAP) has been reported as the pathogenesis of muscle degeneration o
Externí odkaz:
https://doaj.org/article/9bdcceb878174d0dad5ab80684f07298
Autor:
Toshihiro Yamaguchi, Tomokazu S. Sumida, Seitaro Nomura, Masahiro Satoh, Tomoaki Higo, Masamichi Ito, Toshiyuki Ko, Kanna Fujita, Mary E. Sweet, Atsushi Sanbe, Kenji Yoshimi, Ichiro Manabe, Toshikuni Sasaoka, Matthew R. G. Taylor, Haruhiro Toko, Eiki Takimoto, Atsuhiko T. Naito, Issei Komuro
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-8 (2020)
The pathophysiological role of dopamine D1 receptor (D1R) in chronic heart failure remains elusive. Here the authors show that D1R-expressing cardiomyocytes appear in chronic heart failure and play a pivotal role in triggering lethal ventricular arrh
Externí odkaz:
https://doaj.org/article/59249ab8e1b144e4814231c3afc24f46
Autor:
Atsushi Sugiyama, Mihoko Hagiwara-Nagasawa, Ryuichi Kambayashi, Ai Goto, Koki Chiba, Atsuhiko T. Naito, Yasunari Kanda, Akio Matsumoto, Hiroko Izumi-Nakaseko
Publikováno v:
Journal of Pharmacological Sciences, Vol 140, Iss 4, Pp 317-320 (2019)
We investigated the electro-mechanical relationship of human iPS cell-derived cardiomyocyte sheets under arrhythmic condition, which was induced by digitalis intoxication along with the electrical train stimulation (n = 4). We adopted motion vector a
Externí odkaz:
https://doaj.org/article/5dda5c1dbb7c4db8a9b12850f636eac9
Autor:
Atsushi Sugiyama, Mihoko Hagiwara-Nagasawa, Ryuichi Kambayashi, Ai Goto, Koki Chiba, Kentaro Ando, Atsuhiko T. Naito, Hiroko Izumi-Nakaseko
Publikováno v:
Journal of Pharmacological Sciences, Vol 139, Iss 3, Pp 180-185 (2019)
We analyzed how the enhancement of net sarcoplasmic reticulum (SR) Ca2+ uptake may affect cardiac electrophysiological properties in vivo by using caldaret which can decrease SR diastolic Ca2+ leak, enhance SR Ca2+ reuptake and inhibit reverse-mode N
Externí odkaz:
https://doaj.org/article/e316ea54747445f99be06ef857c40f71
Autor:
Ai Goto, Mihoko Hagiwara-Nagasawa, Hiroko Izumi-Nakaseko, Kumiko Kitta, Kiyotaka Hoshiai, Koki Chiba, Kentaro Ando, Yasuki Akie, Atsuhiko T. Naito, Atsushi Sugiyama
Publikováno v:
Journal of Pharmacological Sciences, Vol 138, Iss 3, Pp 198-202 (2018)
Although azithromycin can suppress cardiac INa, IKr, IKs, ICa,L and IK1, its onset mechanisms for cardiovascular death have not been fully investigated. We examined electropharmacological effects of azithromycin in intravenous doses of 0.3, 3 and 30
Externí odkaz:
https://doaj.org/article/dd24b26a681a444fa07908925ce40eac
Autor:
Seitaro Nomura, Masahiro Satoh, Takanori Fujita, Tomoaki Higo, Tomokazu Sumida, Toshiyuki Ko, Toshihiro Yamaguchi, Takashige Tobita, Atsuhiko T. Naito, Masamichi Ito, Kanna Fujita, Mutsuo Harada, Haruhiro Toko, Yoshio Kobayashi, Kaoru Ito, Eiki Takimoto, Hiroshi Akazawa, Hiroyuki Morita, Hiroyuki Aburatani, Issei Komuro
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
The mechanisms underlying the transition from cardiac hypertrophy to heart failure following pressure overload are incompletely understood. Here the authors identify the gene programs encoding the morphological and functional characteristics of cardi
Externí odkaz:
https://doaj.org/article/47e9d418c4d04451afef93ddfe9403d2
Autor:
Hiroko Izumi-Nakaseko, Koki Chiba, Mihoko Hagiwara-Nagasawa, Ayano Satsuka, Ai Goto, Yoshio Nunoi, Ryuichi Kambayashi, Akio Matsumoto, Yoshinori Takei, Yasunari Kanda, Atsuhiko T. Naito, Atsushi Sugiyama
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
Contractility of the human heart increases as its beating rate is elevated, so-called positive force-frequency relationship; however, human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) have been reported to exert a negative force-
Externí odkaz:
https://doaj.org/article/28442419f1ed46e39fe33c246e3ed751
Autor:
Hiroko Izumi-Nakaseko, Mihoko Hagiwara-Nagasawa, Atsuhiko T. Naito, Ai Goto, Koki Chiba, Yuko Sekino, Yasunari Kanda, Atsushi Sugiyama
Publikováno v:
Journal of Pharmacological Sciences, Vol 137, Iss 4, Pp 372-378 (2018)
We examined electrophysiological indices of human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) sheets in order to quantitatively estimate Na+, K+ and Ca2+ channel blocking actions of bepridil and amiodarone using microelectrode ar
Externí odkaz:
https://doaj.org/article/5f801f9b043947e7b986f49b18cd13e1
Autor:
Ai Goto, Hiroko Izumi-Nakaseko, Mihoko Hagiwara-Nagasawa, Koki Chiba, Kentaro Ando, Atsuhiko T. Naito, Atsushi Sugiyama
Publikováno v:
Journal of Pharmacological Sciences, Vol 137, Iss 2, Pp 237-240 (2018)
We analyzed torsadogenic and pharmacokinetic profile of E-4031 using chronic atrioventricular block dogs. E-4031 in intravenous doses of 0.03, 0.1 and 0.3 mg/kg over 10 min prolonged QT/QTc, and increased short-term variability of QT in a dose-relate
Externí odkaz:
https://doaj.org/article/1aab6e0179b14a8ab4a535ddb339d527
Autor:
Suchitra Matsukura, Yuji Nakamura, Kiyotaka Hoshiai, Takashi Hayashi, Tadashi Koga, Ai Goto, Koki Chiba, Nur Jaharat Lubna, Mihoko Hagiwara-Nagasawa, Hiroko Izumi-Nakaseko, Kentaro Ando, Atsuhiko T. Naito, Atsushi Sugiyama
Publikováno v:
Journal of Pharmacological Sciences, Vol 136, Iss 4, Pp 234-241 (2018)
Effects of moxifloxacin on QTc as well as proarrhythmic surrogate markers including J-Tpeakc, Tpeak-Tend and short-term variability (STV) of repolarization were examined by using both standard E14 time-based evaluation and exposure-response modeling.
Externí odkaz:
https://doaj.org/article/4b072f6c9a1e436b85b3f154ccdacb31