Whole-Body Hypothermia vs Targeted Normothermia for Neonates With Mild Encephalopathy: A Multicenter Pilot Randomized Clinical Trial.

Autor: Montaldo P; Centre for Perinatal Neuroscience, Department of Brain Sciences, Imperial College London, London, United Kingdom.; Department of Woman, Child, and General and Specialized Surgery, University of Campania 'Luigi Vanvitelli,' Naples, Italy., Cirillo M; Department of Advanced Medical and Surgical Sciences, MRI Research Center, University of Campania 'Luigi Vanvitelli,' Naples, Italy., Burgod C; Centre for Perinatal Neuroscience, Department of Brain Sciences, Imperial College London, London, United Kingdom., Caredda E; Department of Woman, Child, and General and Specialized Surgery, University of Campania 'Luigi Vanvitelli,' Naples, Italy., Ascione S; Department of Woman, Child, and General and Specialized Surgery, University of Campania 'Luigi Vanvitelli,' Naples, Italy., Carpentieri M; Department of Woman, Child, and General and Specialized Surgery, University of Campania 'Luigi Vanvitelli,' Naples, Italy., Puzone S; Department of Woman, Child, and General and Specialized Surgery, University of Campania 'Luigi Vanvitelli,' Naples, Italy., D'Amico A; Department of Radiology, 'Tortorella' Private Hospital, Salerno, Italy., Garegrat R; Centre for Perinatal Neuroscience, Department of Brain Sciences, Imperial College London, London, United Kingdom., Lanza M; Centre for Perinatal Neuroscience, Department of Brain Sciences, Imperial College London, London, United Kingdom., Moreno Morales M; Centre for Perinatal Neuroscience, Department of Brain Sciences, Imperial College London, London, United Kingdom., Atreja G; Neonatal Unit, Imperial Health Care NHS Trust, London, United Kingdom., Shivamurthappa V; Neonatal Unit, Imperial Health Care NHS Trust, London, United Kingdom., Kariholu U; Neonatal Unit, Imperial Health Care NHS Trust, London, United Kingdom., Aladangady N; Neonatal Unit, Homerton Healthcare NHS Foundation Trust, London, United Kingdom.; Centre for Paediatrics, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom., Fleming P; Neonatal Unit, Homerton Healthcare NHS Foundation Trust, London, United Kingdom.; Centre for Paediatrics, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom., Mathews A; Neonatal Unit, Homerton Healthcare NHS Foundation Trust, London, United Kingdom., Palanisami B; Liverpool Women's NHS Foundation Trust, Liverpool, United Kingdom., Windrow J; Liverpool Women's NHS Foundation Trust, Liverpool, United Kingdom., Harvey K; Liverpool Women's NHS Foundation Trust, Liverpool, United Kingdom., Soe A; Oliver Fisher Neonatal Intensive Care Unit, Medway Maritime Hospital, Medway NHS Foundation Trust, Kent, United Kingdom., Pattnayak S; Oliver Fisher Neonatal Intensive Care Unit, Medway Maritime Hospital, Medway NHS Foundation Trust, Kent, United Kingdom., Sashikumar P; Oliver Fisher Neonatal Intensive Care Unit, Medway Maritime Hospital, Medway NHS Foundation Trust, Kent, United Kingdom., Harigopal S; Neonatal Medicine, Royal Victoria Infirmary, Newcastle Upon Tyne, United Kingdom., Pressler R; Department of Neurophysiology, Great Ormond Street Hospital, London, United Kingdom., Wilson M; Centre for Human Brain Health and School of Psychology, University of Birmingham, Birmingham, United Kingdom., De Vita E; MRI Physics, Radiology Department, Great Ormond Street Hospital for Children NHS Foundation Trust, London, United Kingdom., Shankaran S; Department of Neonatal-Perinatal Medicine, Wayne State University, Detroit, Michigan.; Department of Pediatrics, The University of Texas at Austin, Dell Children's Hospital, Austin, Texas., Thayyil S; Centre for Perinatal Neuroscience, Department of Brain Sciences, Imperial College London, London, United Kingdom.

Publikováno v: JAMA network open [JAMA Netw Open] 2024 May 01; Vol. 7 (5), pp. e249119. Date of Electronic Publication: 2024 May 01.

Therapeutic hypothermia initiated within 6 hours of birth is associated with reduced brain injury on MR biomarkers in mild hypoxic ischemic encephalopathy: a non-randomised cohort study

Autor: Montaldo, P, Lally, P, Oliveira, V, Swamy, R, Mendoza, J, Atreja, G, Kariholu, U, Shivamurthappa, V, Liow, N, Teiserskas, J, Pryce, R, Soe, A, Shankaran, S, Thayyil, S

Publikováno v: F520
F515

Objective To examine the effect of therapeutic hypothermia on MR biomarkers and neurodevelopmental outcomes in babies with mild hypoxic-ischaemic encephalopathy (HIE). Design Non-randomised cohort study. Setting Eight tertiary neonatal units in the U

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1032::c66e119d0a79a6ea0413653a33ab1fcb
http://hdl.handle.net/10044/1/65767

Whole blood gene expression reveals specific transcriptome changes in neonatal encephalopathy

Autor: Montaldo, P, Kaforou, M, Pollara, G, Hervas-Marin, D, Calabria, I, Panadero, J, Pedrola, L, Lally, PJ, Oliveira, V, Kage, A, Atreja, G, Mendoza, J, Soe, A, Pattnayak, S, Shankaran, S, Vento, M, Herberg, J, Thayyil, S

Publikováno v: Neonatology
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
instname

Background: Variable responses to hypothermic neuroprotection are related to the clinical heterogeneity of encephalopathic babies; hence better disease stratification may facilitate the development of individualized neuroprotective therapies. Objecti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::33fbeb35912522c4a483bc2805d74df6
http://hdl.handle.net/10044/1/62898

Hypothermia for moderate or severe neonatal encephalopathy in low-income and middle-income countries (HELIX): a randomised controlled trial in India, Sri Lanka, and Bangladesh.

Autor: Thayyil S; Centre for Perinatal Neuroscience, Imperial College London, London, UK. Electronic address: s.thayyil@imperial.ac.uk., Pant S; Centre for Perinatal Neuroscience, Imperial College London, London, UK., Montaldo P; Centre for Perinatal Neuroscience, Imperial College London, London, UK., Shukla D; Centre for Perinatal Neuroscience, Imperial College London, London, UK., Oliveira V; Centre for Perinatal Neuroscience, Imperial College London, London, UK., Ivain P; Centre for Perinatal Neuroscience, Imperial College London, London, UK., Bassett P; Statsconsultancy, Amersham, London, UK., Swamy R; Perinatal Epidemiology Unit, Bengaluru, Karnataka, India., Mendoza J; Centre for Perinatal Neuroscience, Imperial College London, London, UK., Moreno-Morales M; Centre for Perinatal Neuroscience, Imperial College London, London, UK., Lally PJ; Centre for Perinatal Neuroscience, Imperial College London, London, UK., Benakappa N; Indira Gandhi Institute of Child Health, Bengaluru, Karnataka, India., Bandiya P; Indira Gandhi Institute of Child Health, Bengaluru, Karnataka, India., Shivarudhrappa I; Perinatal Epidemiology Unit, Bengaluru, Karnataka, India; Indira Gandhi Institute of Child Health, Bengaluru, Karnataka, India; Institute of Obstetrics and Gynaecology and Government Hospital for Women and Children, Madras Medical College, Chennai, India., Somanna J; Indira Gandhi Institute of Child Health, Bengaluru, Karnataka, India., Kantharajanna UB; Indira Gandhi Institute of Child Health, Bengaluru, Karnataka, India., Rajvanshi A; Indira Gandhi Institute of Child Health, Bengaluru, Karnataka, India., Krishnappa S; Indira Gandhi Institute of Child Health, Bengaluru, Karnataka, India., Joby PK; Perinatal Epidemiology Unit, Bengaluru, Karnataka, India., Jayaraman K; Institute of Child Health, Madras Medical College, Chennai, India., Chandramohan R; Institute of Child Health, Madras Medical College, Chennai, India., Kamalarathnam CN; Institute of Child Health, Madras Medical College, Chennai, India., Sebastian M; Perinatal Epidemiology Unit, Bengaluru, Karnataka, India; Institute of Child Health, Madras Medical College, Chennai, India., Tamilselvam IA; Institute of Child Health, Madras Medical College, Chennai, India., Rajendran UD; Institute of Child Health, Madras Medical College, Chennai, India., Soundrarajan R; Institute of Child Health, Madras Medical College, Chennai, India., Kumar V; Institute of Child Health, Madras Medical College, Chennai, India., Sudarsanan H; Institute of Child Health, Madras Medical College, Chennai, India., Vadakepat P; Institute of Child Health, Madras Medical College, Chennai, India; Institute of Obstetrics and Gynaecology and Government Hospital for Women and Children, Madras Medical College, Chennai, India., Gopalan K; Institute of Child Health, Madras Medical College, Chennai, India., Sundaram M; Institute of Obstetrics and Gynaecology and Government Hospital for Women and Children, Madras Medical College, Chennai, India., Seeralar A; Institute of Obstetrics and Gynaecology and Government Hospital for Women and Children, Madras Medical College, Chennai, India., Vinayagam P; Institute of Obstetrics and Gynaecology and Government Hospital for Women and Children, Madras Medical College, Chennai, India., Sajjid M; Institute of Obstetrics and Gynaecology and Government Hospital for Women and Children, Madras Medical College, Chennai, India., Baburaj M; Perinatal Epidemiology Unit, Bengaluru, Karnataka, India; Institute of Obstetrics and Gynaecology and Government Hospital for Women and Children, Madras Medical College, Chennai, India., Murugan KD; Institute of Obstetrics and Gynaecology and Government Hospital for Women and Children, Madras Medical College, Chennai, India., Sathyanathan BP; Barnard Institute of Radiology, Madras Medical College, Chennai, India., Kumaran ES; Barnard Institute of Radiology, Madras Medical College, Chennai, India., Mondkar J; Lokmanya Tilak Municipal Medical College, Mumbai, Maharashtra, India., Manerkar S; Lokmanya Tilak Municipal Medical College, Mumbai, Maharashtra, India., Joshi AR; Lokmanya Tilak Municipal Medical College, Mumbai, Maharashtra, India., Dewang K; Lokmanya Tilak Municipal Medical College, Mumbai, Maharashtra, India., Bhisikar SM; Lokmanya Tilak Municipal Medical College, Mumbai, Maharashtra, India., Kalamdani P; Lokmanya Tilak Municipal Medical College, Mumbai, Maharashtra, India., Bichkar V; Lokmanya Tilak Municipal Medical College, Mumbai, Maharashtra, India., Patra S; Lokmanya Tilak Municipal Medical College, Mumbai, Maharashtra, India., Jiwnani K; Lokmanya Tilak Municipal Medical College, Mumbai, Maharashtra, India., Shahidullah M; Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh., Moni SC; Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh., Jahan I; Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh., Mannan MA; Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh., Dey SK; Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh., Nahar MN; National Institute of Neurosciences, Dhaka, Bangladesh., Islam MN; National Institute of Neurosciences, Dhaka, Bangladesh., Shabuj KH; Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh., Rodrigo R; University of Kelaniya, Colombo, Sri Lanka., Sumanasena S; University of Kelaniya, Colombo, Sri Lanka., Abayabandara-Herath T; University of Kelaniya, Colombo, Sri Lanka., Chathurangika GK; University of Kelaniya, Colombo, Sri Lanka., Wanigasinghe J; University of Colombo, Colombo, Sri Lanka., Sujatha R; Sree Avittom Thirunal Hospital and Government Medical College, Thiruvananthapuram, Kerala, India., Saraswathy S; Sree Avittom Thirunal Hospital and Government Medical College, Thiruvananthapuram, Kerala, India., Rahul A; Sree Avittom Thirunal Hospital and Government Medical College, Thiruvananthapuram, Kerala, India., Radha SJ; Sree Avittom Thirunal Hospital and Government Medical College, Thiruvananthapuram, Kerala, India., Sarojam MK; Sree Avittom Thirunal Hospital and Government Medical College, Thiruvananthapuram, Kerala, India., Krishnan V; Institute of Maternal and Child Health, Government Medical College, Kozhikode, Kerala, India., Nair MK; Institute of Maternal and Child Health, Government Medical College, Kozhikode, Kerala, India., Devadas S; Vanivilas Hospital, Bangalore Medical College and Research Institute, Karnataka, India., Chandriah S; Vanivilas Hospital, Bangalore Medical College and Research Institute, Karnataka, India., Venkateswaran H; Perinatal Epidemiology Unit, Bengaluru, Karnataka, India., Burgod C; Centre for Perinatal Neuroscience, Imperial College London, London, UK., Chandrasekaran M; Perinatal Epidemiology Unit, Bengaluru, Karnataka, India., Atreja G; Centre for Perinatal Neuroscience, Imperial College London, London, UK., Muraleedharan P; Perinatal Epidemiology Unit, Bengaluru, Karnataka, India., Herberg JA; Section of Paediatric Infectious Disease, Imperial College London, London, UK., Kling Chong WK; Centre for Perinatal Neuroscience, Imperial College London, London, UK; Department of Neuroradiology, Great Ormond Street Hospital, London, UK., Sebire NJ; Perinatal Pathology, National Institute for Health Research Biomedical Research Centre, Great Ormond Street Hospital for Children, University College London, London, UK., Pressler R; Department of Neurophysiology, Great Ormond Street Hospital, London, UK., Ramji S; Maulana Azad Medical College, New Delhi, India., Shankaran S; Neonatal-Perinatal Medicine, Wayne State University, Detroit, MI, USA.

Publikováno v: The Lancet. Global health [Lancet Glob Health] 2021 Sep; Vol. 9 (9), pp. e1273-e1285. Date of Electronic Publication: 2021 Aug 03.

Biphasic positive airway pressure prevented the reintubation of extremely preterm infants more effectively than continuous positive airway pressure.

Autor: Rallis D; Neonatal Unit, Imperial College Healthcare NHS Trust, London, UK., Sathiyamurthy S; Neonatal Unit, Imperial College Healthcare NHS Trust, London, UK., Deierl A; Neonatal Unit, Imperial College Healthcare NHS Trust, London, UK., Atreja G; Neonatal Unit, Imperial College Healthcare NHS Trust, London, UK., Chaban B; Neonatal Unit, Imperial College Healthcare NHS Trust, London, UK., Banerjee J; Neonatal Unit, Imperial College Healthcare NHS Trust, London, UK.

Publikováno v: Acta paediatrica (Oslo, Norway : 1992) [Acta Paediatr] 2019 Sep; Vol. 108 (9), pp. 1725-1726. Date of Electronic Publication: 2019 Jun 17.