Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Atousa Khiabany"'
Autor:
James Spicer, Bristi Basu, Ana Montes, Udai Banerji, Rebecca Kristeleit, Rowan Miller, Gareth J. Veal, Christopher J. Corrigan, Stephen J. Till, Mariangela Figini, Silvana Canevari, Claire Barton, Paul Jones, Sarah Mellor, Simon Carroll, Chris Selkirk, George Nintos, Vineet Kwatra, Ionut-Gabriel Funingana, Gary Doherty, Hannah J. Gould, Giulia Pellizzari, Mano Nakamura, Kristina M. Ilieva, Atousa Khiabany, Chara Stavraka, Jitesh Chauhan, Cheryl Gillett, Sarah Pinder, Heather J. Bax, Debra H. Josephs, Sophia N. Karagiannis
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)
Abstract All antibodies approved for cancer therapy are monoclonal IgGs but the biology of IgE, supported by comparative preclinical data, offers the potential for enhanced effector cell potency. Here we report a Phase I dose escalation trial (NCT025
Externí odkaz:
https://doaj.org/article/10c6fe5134614037a52da348794ee12d
Autor:
Rosalind Graham, Patrycja Gazinska, Birong Zhang, Atousa Khiabany, Shubhankar Sinha, Thanussuyah Alaguthurai, Fabian Flores-Borja, Jose Vicencio, Fabienne Beuron, Ioannis Roxanis, Rafal Matkowski, Revadee Liam-Or, Andrew Tutt, Tony Ng, Khuloud T. Al-Jamal, You Zhou, Sheeba Irshad
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
BackgroundIntracellular communication within the tumour is complex and extracellular vesicles (EVs) have been identified as major contributing factors for the cell-to-cell communication in the local and distant tumour environments. Here, we examine t
Externí odkaz:
https://doaj.org/article/6751835215264410a344fd60c77e7254
Autor:
Duaa O. Khair, Heather J. Bax, Silvia Mele, Silvia Crescioli, Giulia Pellizzari, Atousa Khiabany, Mano Nakamura, Robert J. Harris, Elise French, Ricarda M. Hoffmann, Iwan P. Williams, Anthony Cheung, Benjamin Thair, Charlie T. Beales, Emma Touizer, Adrian W. Signell, Nahrin L. Tasnova, James F. Spicer, Debra H. Josephs, Jenny L. Geh, Alastair MacKenzie Ross, Ciaran Healy, Sophie Papa, Katie E. Lacy, Sophia N. Karagiannis
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
The immune system employs several checkpoint pathways to regulate responses, maintain homeostasis and prevent self-reactivity and autoimmunity. Tumor cells can hijack these protective mechanisms to enable immune escape, cancer survival and proliferat
Externí odkaz:
https://doaj.org/article/b0ae52ae6a4746d783b3011fbf5f7d7e
Autor:
Mano Nakamura, Elmira Amiri Souri, Gabriel Osborn, Roman Laddach, Jitesh Chauhan, Chara Stavraka, Sara Lombardi, Anna Black, Atousa Khiabany, Duaa O. Khair, Mariangela Figini, Anna Winship, Sharmistha Ghosh, Ana Montes, James F. Spicer, Heather J. Bax, Debra H. Josephs, Katie E. Lacy, Sophia Tsoka, Sophia N. Karagiannis
Publikováno v:
Cancers, Vol 12, Iss 11, p 3376 (2020)
IgE contributes to host-protective functions in parasitic and bacterial infections, often by monocyte and macrophage recruitment. We previously reported that monocytes contribute to tumour antigen-specific IgE-mediated tumour growth restriction in ro
Externí odkaz:
https://doaj.org/article/a43bc7ac15c04fcfba2107a385e34f2e
Autor:
Heather J. Bax, Jitesh Chauhan, Chara Stavraka, Atousa Khiabany, Mano Nakamura, Giulia Pellizzari, Kristina M. Ilieva, Sara Lombardi, Hannah J. Gould, Christopher J. Corrigan, Stephen J. Till, Sidath Katugampola, Paul S. Jones, Claire Barton, Anna Winship, Sharmistha Ghosh, Ana Montes, Debra H. Josephs, James F. Spicer, Sophia N. Karagiannis
Publikováno v:
Cells, Vol 9, Iss 7, p 1631 (2020)
Basophils are involved in manifestations of hypersensitivity, however, the current understanding of their propensity for activation and their prognostic value in cancer patients remains unclear. As in healthy and atopic individuals, basophil populati
Externí odkaz:
https://doaj.org/article/caee5e2d6a73467a978d97ba24be3e41
Autor:
Heather J. Bax, Jitesh Chauhan, Chara Stavraka, Aida Santaolalla, Gabriel Osborn, Atousa Khiabany, Melanie Grandits, Jacobo López-Abente, Lais C. G. F. Palhares, Charleen Chan Wah Hak, Alexandra Robinson, Amy Pope, Natalie Woodman, Cristina Naceur-Lombardelli, Sadek Malas, Jack E. M. Coumbe, Mano Nakamura, Roman Laddach, Silvia Mele, Silvia Crescioli, Anna M. Black, Sara Lombardi, Silvana Canevari, Mariangela Figini, Ahmad Sayasneh, Sophia Tsoka, Kevin FitzGerald, Cheryl Gillett, Sarah Pinder, Mieke Van Hemelrijck, Rebecca Kristeleit, Sharmistha Ghosh, Ana Montes, James Spicer, Sophia N. Karagiannis, Debra H. Josephs
Publikováno v:
Bax, H, Chauhan, J, Stavraka, C, Santaolalla, A, Osborn, G, Khiabany, A, Grandits, M, Lopez-Abente Muroz, J, Gusmao Ferreira, L C, Chan Wah Hak, C, Robinson, A, Pope, A, Woodman, N, Naceur-Lombardelli, C, Malas, S, Nakamura, M, Coumbe, J E M, Laddach, R, Mele, S, Crescioli, S, Black, A, Lombardi, S, Canevari, S, Figini, M, Sayasneh, A, Tsoka, S, FitzGerald, K, Gillett, C, Pinder, S, Van Hemelrijck, M, Kristeleit, R, Ghosh, S, Montes, A, Spicer, J, Karagiannis, S N & Josephs, D 2022, ' Folate receptor alpha in ovarian cancer tissue and patient serum is associated with disease burden and treatment outcomes ', British Journal of Cancer . https://doi.org/10.1038/s41416-022-02031-x
Background Survival rates for ovarian cancer remain poor, and monitoring and prediction of therapeutic response may benefit from additional markers. Ovarian cancers frequently overexpress Folate Receptor alpha (FRα) and the soluble receptor (sFRα)
Publikováno v:
British Journal of Surgery. 109
Background Patients with CDH1 (E-cadherin) gene mutations have a 60–80% increased lifetime risk of hereditary diffuse gastric cancer (HDGC). Although prophylactic total gastrectomy may reduce long-term risk of gastric cancers, the associated morbid
Autor:
Sara A. Lombardi, Katie E. Lacy, Sophia N. Karagiannis, Mano Nakamura, Debra H. Josephs, Anna Winship, Roman Laddach, Anna Black, Mariangela Figini, Elmira Amiri Souri, James Spicer, Duaa O. Khair, Chara Stavraka, Ana Montes, Sophia Tsoka, Sharmistha Ghosh, Heather J. Bax, Jitesh Chauhan, Gabriel Osborn, Atousa Khiabany
Publikováno v:
Cancers, Vol 12, Iss 3376, p 3376 (2020)
Cancers
Volume 12
Issue 11
Cancers
Volume 12
Issue 11
IgE contributes to host-protective functions in parasitic and bacterial infections, often by monocyte and macrophage recruitment. We previously reported that monocytes contribute to tumour antigen-specific IgE-mediated tumour growth restriction in ro
Autor:
Duaa O, Khair, Heather J, Bax, Silvia, Mele, Silvia, Crescioli, Giulia, Pellizzari, Atousa, Khiabany, Mano, Nakamura, Robert J, Harris, Elise, French, Ricarda M, Hoffmann, Iwan P, Williams, Anthony, Cheung, Benjamin, Thair, Charlie T, Beales, Emma, Touizer, Adrian W, Signell, Nahrin L, Tasnova, James F, Spicer, Debra H, Josephs, Jenny L, Geh, Alastair, MacKenzie Ross, Ciaran, Healy, Sophie, Papa, Katie E, Lacy, Sophia N, Karagiannis
Publikováno v:
Khair, D O, Bax, H J, Mele, S, Crescioli, S, Pellizzari, G, Khiabany, A, Nakamura, M, Harris, R J, French, E, Hoffmann, R M, Williams, I P, Cheung, K K A, Thair, B, Beales, C T, Touizer, E, Signell, A W, Tasnova, N L, Spicer, J F, Josephs, D H, Geh, J L C, MacKenzie Ross, A, Healy, C, Papa, S E, Lacy, K E & Karagiannis, S N 2019, ' Combining Immune Checkpoint Inhibitors: Established and Emerging Targets and Strategies to Improve Outcomes in Melanoma ', Frontiers in Immunology, no. MAR, 453 . https://doi.org/10.3389/fimmu.2019.00453
Frontiers in Immunology
Frontiers in Immunology
The immune system employs several checkpoint pathways to regulate responses, maintain homeostasis and prevent self-reactivity and autoimmunity. Tumor cells can hijack these protective mechanisms to enable immune escape, cancer survival and proliferat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::6a105eb2a223f32d9f535b0a71fd7e0a
https://kclpure.kcl.ac.uk/en/publications/e8c5d421-3b0c-4218-a0ee-cb661eb30f6e
https://kclpure.kcl.ac.uk/en/publications/e8c5d421-3b0c-4218-a0ee-cb661eb30f6e
Autor:
Sarah Mellor, Jitesh Chauhan, Atousa Khiabany, Heike Lentfer, Gareth J. Veal, George Nintos, Bristi Basu, Susan Brook, Mano Nakamura, Sophia N. Karagiannis, Katie Stoddart, Kristina M. Ilieva, Giulia Pellizzari, Stephen J. Till, Ionut G. Funingana, Chara Stavraka, Debra H. Josephs, Annie Griffin, Kam Zaki, Ana Montes, Paul W. Jones, James Spicer, Christopher Selkirk, Sarah E Pinder, Heather J. Bax, Simon Carroll, Amy Pope, Joo Ern Ang, Timothy Brier, Natalie Woodman, Claire Barton, Rebecca Kristeleit, Christopher Corrigan, Udai Banerji, Hannah J. Gould
Publikováno v:
Cancer Research. 80:CT141-CT141
Background: All antibodies approved for the treatment of cancer are monoclonal IgGs, and no IgE therapy has yet been tested in humans. The biology of IgE, compared with IgG, offers potential for enhanced immune surveillance and superior effector cell