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Autor:
Daiki Karigane, Kinya Otsu, Shinichiro Okamoto, Nobuhito Goda, Takayuki Morikawa, Hiroshi Kobayashi, Yuriko Sorimachi, Yoshiaki Kubota, Yukako Ootomo, Keiyo Takubo
Publikováno v:
The Journal of Biological Chemistry
Hematopoietic stem cells (HSCs) and their progeny sustain lifetime hematopoiesis. Aging alters HSC function, number, and composition and increases risk of hematological malignancies, but how these changes occur in HSCs remains unclear. Signaling via