Pre-40S ribosome biogenesis factor Tsr1 is an inactive structural mimic of translational GTPases

Autor: Urszula M. McCaughan, Uma Jayachandran, Vadim Shchepachev, Zhuo Angel Chen, Juri Rappsilber, David Tollervey, Atlanta G. Cook

Publikováno v: Nature Communications, Vol 7, Iss 1, Pp 1-8 (2016)

Tsr1 is an essential ribosome biogenesis factor that has known similarity to GTPases. Here, the authors report the Tsr1 crystal structure and show that it is similar to GTPases but that active site residues are not conserved; modelling of the structu

Externí odkaz: https://doaj.org/article/71478f9399644dc58a00d02238d1c896

A network of DZF proteins controls alternative splicing regulation and fidelity

Autor: Nazmul Haque, Alexander Will, Atlanta G. Cook, J. Robert Hogg

Proteins containing DZF (domain associated with zinc fingers) modules play important roles throughout gene expression, from transcription to translation. Derived from nucleotidyltransferases but lacking catalytic residues, DZF domains serve as hetero

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3bab3da0f25af8742d7b39427abdad3
https://doi.org/10.1101/2022.06.15.495552

Structure of SALL4 zinc finger domain reveals link between AT-rich DNA binding and Okihiro syndrome

Autor: James A Watson, Raphaël Pantier, Uma Jayachandran, Kashyap Chhatbar, Beatrice Alexander-Howden, Valdeko Kruusvee, Michal Prendecki, Adrian Bird, Atlanta G Cook

Publikováno v: Watson, J A, Pantier, R, Jayachandran, U, Chhatbar, K, Alexander-Howden, B, Kruusvee, V, Prendecki, M, Bird, A & Cook, A G 2023, ' Structure of SALL4 zinc finger domain reveals link between AT-rich DNA binding and Okihiro syndrome ', Life Science Alliance, vol. 6, no. 3 . https://doi.org/10.26508/lsa.202201588
Watson, J, Pantier, R, Jayachandran, U, Chhatbar, K, Alexander-Howden, B, Kruusvee, V, Prendecki, M, Bird, A P & Cook, A G 2023, ' Structure of SALL4 zinc-finger domain reveals link between AT-rich DNA binding and Okihiro syndrome ', Life Science Alliance, vol. 6, no. 3, e202201588 . https://doi.org/10.26508/lsa.202201588

Spalt-like 4 (SALL4) maintains vertebrate embryonic stem cell identity and is required for the development of multiple organs, including limbs. Mutations in SALL4 are associated with Okihiro syndrome, and SALL4 is also a known target of thalidomide.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3703f5f9b87bf7d47e8aff81701010b5
https://doi.org/10.26508/lsa.202201588

Missense Variants Reveal Functional Insights Into the Human ARID Family of Gene Regulators

Autor: Atlanta G. Cook, Gauri Deak

Publikováno v: Deák, G & Cook, A G 2022, ' Missense variants reveal functional insights into the human ARID family of gene regulators ', Journal of Molecular Biology, vol. 434, no. 9, 167529 . https://doi.org/10.1016/j.jmb.2022.167529

Missense variants are alterations to protein coding sequences that result in amino acid substitutions. They can be deleterious if the amino acid is required for maintaining structure or/and function, but are likely to be tolerated at other sites. Con

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e4d18f848bcb03ce3cc0d9b4ae9a7ce
https://doi.org/10.1016/j.jmb.2022.167529

SPOCD1 is an essential executor of piRNA-directed de novo DNA methylation

Autor: Robin C. Allshire, Madeleine Heep, Alena Shkumatava, Dónal O'Carroll, Yuka Kabayama, Lina Vasiliauskaitė, Yuvia A. Pérez-Rico, Ansgar Zoch, Rebecca V. Berrens, Juri Rappsilber, Atlanta G. Cook, Tania Auchynnikava, Theresa Schöpp

Publikováno v: Nature

In mammals, the acquisition of the germline from the soma provides the germline with an essential challenge: the need to erase and reset genomic methylation1. In the male germline, RNA-directed DNA methylation silences young, active transposable elem

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ce0128b501c405c72070577c37d9f09