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In patients with severe alcoholic hepatitis, prednisolone increases susceptibility to infection and infection-related mortality, associated with high circulating levels of bacterial DNA

Autor: Vergis, N, Atkinson, SR, Knapp, S, Maurice, J, Allison, M, Austin, A, Forrest, EH, Masson, S, McCune, A, Patch, D, Ryder, S, Wright, M, Thursz, MR

BACKGROUND & AIMS: Infections are common in patients with severe alcoholic hepatitis (SAH), but little information is available on how to predict their development or their effects on patients. Prednisolone is advocated for treatment of SAH, but can

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1032::d0b3264d001174cca4216246283b0887
http://hdl.handle.net/10044/1/44797

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Defective monocyte oxidative burst predicts infection in alcoholic hepatitis and is associated with reduced expression of NADPH oxidase

Objective In order to explain the increased susceptibility to serious infection in alcoholic hepatitis, we evaluated monocyte phagocytosis, aberrations of associated signalling pathways and their reversibility, and whether phagocytic defects could pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1032::8e9defbdfaadd8d1908745ff4e665a46
http://hdl.handle.net/10044/1/27705

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Widespread exon skipping triggers degradation by nuclear RNA surveillance in fission yeast

Autor: Bitton, DA, Atkinson, SR, Rallis, C, Smith, GC, Ellis, DA, Chen, YY, Malecki, M, Codlin, S, Lemay, JF, Cotobal, C, Bachand, F, Marguerat, S, Mata, J, Bähler, J

Exon skipping is considered a principal mechanism by which eukaryotic cells expand their transcriptome and proteome repertoires, creating different splice variants with distinct cellular functions. Here we analyze RNA-seq data from 116 transcriptomes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1032::72e2524913f0d9a627bab0c0b5e8d6ca
http://hdl.handle.net/10044/1/24624

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