Multiomics of Tissue Extracellular Vesicles Identifies Unique Modulators of Atherosclerosis and Calcific Aortic Valve Stenosis.

Autor: Blaser MC; Center for Interdisciplinary Cardiovascular Sciences, Cardiovascular Division, Department of Medicine (M.C.B., F.B., A.H., M.E.T., F.S., H.H., C.L.C., L.A.S., S.K.A., M.A.R., T.P., S.A.S., M.A., E.A.)., Buffolo F; Center for Interdisciplinary Cardiovascular Sciences, Cardiovascular Division, Department of Medicine (M.C.B., F.B., A.H., M.E.T., F.S., H.H., C.L.C., L.A.S., S.K.A., M.A.R., T.P., S.A.S., M.A., E.A.)., Halu A; Center for Interdisciplinary Cardiovascular Sciences, Cardiovascular Division, Department of Medicine (M.C.B., F.B., A.H., M.E.T., F.S., H.H., C.L.C., L.A.S., S.K.A., M.A.R., T.P., S.A.S., M.A., E.A.).; Channing Division of Network Medicine, Department of Medicine (A.H., M.A.)., Turner ME; Center for Interdisciplinary Cardiovascular Sciences, Cardiovascular Division, Department of Medicine (M.C.B., F.B., A.H., M.E.T., F.S., H.H., C.L.C., L.A.S., S.K.A., M.A.R., T.P., S.A.S., M.A., E.A.)., Schlotter F; Center for Interdisciplinary Cardiovascular Sciences, Cardiovascular Division, Department of Medicine (M.C.B., F.B., A.H., M.E.T., F.S., H.H., C.L.C., L.A.S., S.K.A., M.A.R., T.P., S.A.S., M.A., E.A.)., Higashi H; Center for Interdisciplinary Cardiovascular Sciences, Cardiovascular Division, Department of Medicine (M.C.B., F.B., A.H., M.E.T., F.S., H.H., C.L.C., L.A.S., S.K.A., M.A.R., T.P., S.A.S., M.A., E.A.)., Pantano L; T H Chan School of Public Health, Harvard University, Boston, MA (L.P.)., Clift CL; Center for Interdisciplinary Cardiovascular Sciences, Cardiovascular Division, Department of Medicine (M.C.B., F.B., A.H., M.E.T., F.S., H.H., C.L.C., L.A.S., S.K.A., M.A.R., T.P., S.A.S., M.A., E.A.)., Saddic LA; Center for Interdisciplinary Cardiovascular Sciences, Cardiovascular Division, Department of Medicine (M.C.B., F.B., A.H., M.E.T., F.S., H.H., C.L.C., L.A.S., S.K.A., M.A.R., T.P., S.A.S., M.A., E.A.)., Atkins SK; Center for Interdisciplinary Cardiovascular Sciences, Cardiovascular Division, Department of Medicine (M.C.B., F.B., A.H., M.E.T., F.S., H.H., C.L.C., L.A.S., S.K.A., M.A.R., T.P., S.A.S., M.A., E.A.)., Rogers MA; Center for Interdisciplinary Cardiovascular Sciences, Cardiovascular Division, Department of Medicine (M.C.B., F.B., A.H., M.E.T., F.S., H.H., C.L.C., L.A.S., S.K.A., M.A.R., T.P., S.A.S., M.A., E.A.)., Pham T; Center for Interdisciplinary Cardiovascular Sciences, Cardiovascular Division, Department of Medicine (M.C.B., F.B., A.H., M.E.T., F.S., H.H., C.L.C., L.A.S., S.K.A., M.A.R., T.P., S.A.S., M.A., E.A.)., Vromman A; Channing Division of Network Medicine, Department of Medicine (A.H., M.A.)., Shvartz E; Channing Division of Network Medicine, Department of Medicine (A.H., M.A.)., Sukhova GK; Channing Division of Network Medicine, Department of Medicine (A.H., M.A.)., Monticone S; Division of Internal Medicine and Hypertension (S.M.), University of Torino, Italy., Camussi G; Department of Medical Sciences (G.C.), University of Torino, Italy., Robson SC; Center for Inflammation Research, Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA (S.C.R.)., Body SC; Boston University School of Medicine, Boston, MA (S.C.B.)., Muehlschlegel JD; Center for Perioperative Genomics, Department of Anesthesiology, Perioperative and Pain Medicine (J.D.M.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA., Singh SA; Center for Interdisciplinary Cardiovascular Sciences, Cardiovascular Division, Department of Medicine (M.C.B., F.B., A.H., M.E.T., F.S., H.H., C.L.C., L.A.S., S.K.A., M.A.R., T.P., S.A.S., M.A., E.A.)., Aikawa M; Center for Interdisciplinary Cardiovascular Sciences, Cardiovascular Division, Department of Medicine (M.C.B., F.B., A.H., M.E.T., F.S., H.H., C.L.C., L.A.S., S.K.A., M.A.R., T.P., S.A.S., M.A., E.A.).; Channing Division of Network Medicine, Department of Medicine (A.H., M.A.).; Center for Excellence in Vascular Biology, Cardiovascular Division, Department of Medicine (A.V., E.S., G.K.S., M.A., E.A.)., Aikawa E; Center for Interdisciplinary Cardiovascular Sciences, Cardiovascular Division, Department of Medicine (M.C.B., F.B., A.H., M.E.T., F.S., H.H., C.L.C., L.A.S., S.K.A., M.A.R., T.P., S.A.S., M.A., E.A.).; Center for Excellence in Vascular Biology, Cardiovascular Division, Department of Medicine (A.V., E.S., G.K.S., M.A., E.A.).

Publikováno v: Circulation [Circulation] 2023 Aug 22; Vol. 148 (8), pp. 661-678. Date of Electronic Publication: 2023 Jul 10.

Lipoprotein(a) Induces Vesicular Cardiovascular Calcification Revealed With Single-Extracellular Vesicle Analysis.

Autor: Rogers MA; Center for Interdisciplinary Cardiovascular Sciences, Harvard Medical School, Brigham and Women's Hospital, Boston, MA, United States., Atkins SK; Center for Interdisciplinary Cardiovascular Sciences, Harvard Medical School, Brigham and Women's Hospital, Boston, MA, United States., Zheng KH; Center for Interdisciplinary Cardiovascular Sciences, Harvard Medical School, Brigham and Women's Hospital, Boston, MA, United States.; Department of Vascular Medicine, Academic Medical Center, Amsterdam UMC, Amsterdam, Netherlands., Singh SA; Center for Interdisciplinary Cardiovascular Sciences, Harvard Medical School, Brigham and Women's Hospital, Boston, MA, United States., Chelvanambi S; Center for Interdisciplinary Cardiovascular Sciences, Harvard Medical School, Brigham and Women's Hospital, Boston, MA, United States., Pham TH; Center for Interdisciplinary Cardiovascular Sciences, Harvard Medical School, Brigham and Women's Hospital, Boston, MA, United States., Kuraoka S; Center for Interdisciplinary Cardiovascular Sciences, Harvard Medical School, Brigham and Women's Hospital, Boston, MA, United States., Stroes ESG; Department of Vascular Medicine, Academic Medical Center, Amsterdam UMC, Amsterdam, Netherlands., Aikawa M; Center for Interdisciplinary Cardiovascular Sciences, Harvard Medical School, Brigham and Women's Hospital, Boston, MA, United States.; Center for Excellence in Vascular Biology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, United States., Aikawa E; Center for Interdisciplinary Cardiovascular Sciences, Harvard Medical School, Brigham and Women's Hospital, Boston, MA, United States.; Center for Excellence in Vascular Biology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, United States.

Publikováno v: Frontiers in cardiovascular medicine [Front Cardiovasc Med] 2022 Jan 28; Vol. 9, pp. 778919. Date of Electronic Publication: 2022 Jan 28 (Print Publication: 2022).

Calcific Aortic Valve Disease "Omics" Is Timely, But Are We Looking Too Late?

Autor: Atkins SK; Center for Interdisciplinary Cardiovascular Sciences, Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA., Singh SA; Center for Interdisciplinary Cardiovascular Sciences, Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA., Aikawa E; Center for Interdisciplinary Cardiovascular Sciences, Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.; Center for Excellence in Vascular Biology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.; Department of Human Pathology, Sechenov First Moscow State Medical University, Moscow, Russia.

Publikováno v: JACC. Basic to translational science [JACC Basic Transl Sci] 2020 Dec 28; Vol. 5 (12), pp. 1178-1180. Date of Electronic Publication: 2020 Dec 28 (Print Publication: 2020).

Letter by Shar et al Regarding Article, "Low and Oscillatory Wall Shear Stress Is Not Related to Aortic Dilation in Patients With Bicuspid Aortic Valve: A Time-Resolved 3-Dimensional Phase-Contrast Magnetic Resonance Imaging Study".

Autor: Shar JA; From the Department of Mechanical and Materials Engineering, Wright State University, Russ Engineering Center, Dayton, OH (J.A.S., J.L., P.S.)., Liu J; From the Department of Mechanical and Materials Engineering, Wright State University, Russ Engineering Center, Dayton, OH (J.A.S., J.L., P.S.)., Atkins SK; Center for Interdisciplinary Cardiovascular Sciences, Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (S.K.A.)., Sucosky P; From the Department of Mechanical and Materials Engineering, Wright State University, Russ Engineering Center, Dayton, OH (J.A.S., J.L., P.S.).

Publikováno v: Arteriosclerosis, thrombosis, and vascular biology [Arterioscler Thromb Vasc Biol] 2020 Apr; Vol. 40 (4), pp. e114-e115. Date of Electronic Publication: 2020 Mar 25.

Simulations of morphotype-dependent hemodynamics in non-dilated bicuspid aortic valve aortas.

Autor: Cao K; Department of Aerospace and Mechanical Engineering, University of Notre Dame, Notre Dame, IN, USA., Atkins SK; Department of Aerospace and Mechanical Engineering, University of Notre Dame, Notre Dame, IN, USA., McNally A; Department of Aerospace and Mechanical Engineering, University of Notre Dame, Notre Dame, IN, USA., Liu J; Department of Mechanical and Materials Engineering, Wright State University, Dayton, OH, USA., Sucosky P; Department of Mechanical and Materials Engineering, Wright State University, Dayton, OH, USA. Electronic address: philippe.sucosky@wright.edu.

Publikováno v: Journal of biomechanics [J Biomech] 2017 Jan 04; Vol. 50, pp. 63-70. Date of Electronic Publication: 2016 Nov 11.