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Proinflammatory cytokine profile is critical in autocrine GH-triggered curcumin resistance engulf by atiprimod cotreatment in MCF-7 and MDA-MB-231 breast cancer cells

Autor: Tunc Akkoc, Berfin Ergen, Pınar Obakan-Yerlikaya, Berre-Serra Akdeniz, Ajda Coker-Gurkan, Elif Damla Arisan, Buse Ozakaltun

Publikováno v: Molecular Biology Reports. 47:8797-8808

Active growth hormone (GH) signaling triggers cellular growth and invasion-metastasis in colon, breast, and prostate cancer. Curcumin, an inhibitor of NF-kappa B pathway, is assumed to be a promising anti-carcinogenic agent. Atiprimod is also an anti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3da4275d85f9bd2be643bf73131a035a
https://doi.org/10.1007/s11033-020-05928-z

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Atiprimod triggered apoptotic cell death via acting on PERK/eIF2α/ATF4/CHOP and STAT3/NF-ΚB axis in MDA-MB-231 and MDA-MB-468 breast cancer cells

Autor: Elif Damla Arisan, Pınar Obakan-Yerlikaya, Ajda Coker-Gurkan, Esin Can, Semanur Sahin

Purpose: The constitutive activation of STAT3 through receptor tyrosine kinases triggered breast cancer cell growth, and invasion-metastasis. Atiprimod impacts anti-proliferative, anti-carcinogenic effects in hepatocellular carcinoma, lymphoma, multi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::112aae5fc9b884ffad3302ef23a0936b
https://hdl.handle.net/20.500.12445/2493

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Atiprimod induce apoptosis in pituitary adenoma: Endoplasmic reticulum stress and autophagy pathways

Autor: Pınar Obakan-Yerlikaya, Ajda Coker-Gurkan, Narcin Palavan-Unsal, Gizem Keceloglu, Burcu Ayhan-Sahin, Elif Damla Arisan

Publikováno v: Journal of cellular biochemistry. 120(12)

Pituitary adenoma is the most common tumor with a high recurrence rate due to a hormone-dependent JAK/signal transducer and activator of transcriptions (STAT) signaling. Atiprimod, a novel compound belonging to the azaspirane class of cationic amphip

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5603bd60b7a3c032481f899d3b6851b
https://pubmed.ncbi.nlm.nih.gov/31270852

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Akademický článek

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Akademický článek

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Combination of atiprimod and the proteasome inhibitor bortezomib induces apoptosis of mantle cell lymphoma in vitro and in vivo

Autor: Jing Yang, Wenli Dong, Qing Yi, Luhong Sun, Jianfei Qian, Liang Zhang, Michael Wang

Publikováno v: Leukemia Research. 36:363-368

The proteasome inhibitor bortezomib (BTZ) is known to be chemotherapeutic in relapsed or refractory mantle cell lymphoma (MCL). Atiprimod (ATI), a novel cationic amphophilic compound, has been tested in clinical trials in multiple myeloma (MM). We so

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a92a014e7be41e6a3dbe6f42a8693c0
https://doi.org/10.1016/j.leukres.2011.09.014

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Preclinical characterization of atiprimod, a novel JAK2 AND JAK3 inhibitor

Autor: Zeev Estrov, Srdan Verstovsek, Amos Gaikwad, Ying Zhang, Hagop M. Kantarjian, Alfonso Quintás-Cardama, Taghi Manshouri, David Harris

Publikováno v: Investigational New Drugs. 29:818-826

We herein report on the activity of the JAK2/JAK3 small molecule inhibitor atiprimod on mouse FDCP-EpoR cells carrying either wild-type (JAK2 (WT)) or mutant (JAK2 (V617F)) JAK2, human acute megakaryoblastic leukemia cells carrying JAK2 (V617F) (SET-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cedbfa70e6e17e008bf8cd456bafccdd
https://doi.org/10.1007/s10637-010-9429-z

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Caspase-Independent Pathways of Programmed Cell Death: The Unraveling of New Targets of Cancer Therapy?

Autor: Constantinou, Constantina, Papas, Konstantinos A., Constantinou, Andreas I.

Publikováno v: Current Cancer Drug Targets
Curr.Cancer Drug Targets

In the past few years, accumulating evidence in the literature supports the existence of pathways of caspase-independent programmed cell death (CI-PCD). These pathways are likely to be acting as 'death backup systems' that ensure effective removal of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f95f44db4484ec1851baf66add766d4
https://doi.org/10.2174/156800909789271512

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A Severe Combined Immunodeficient–hu In vivo Mouse Model of Human Primary Mantle Cell Lymphoma

Autor: Xiaohong Han, Jorge E. Romaguera, Qing Yi, Yuankai Shi, Jing Yang, Michael Wang, Sungyoul Hong, Jianfei Qian, Liang Zhang, Pei Lin, Larry W. Kwak

Publikováno v: Clinical Cancer Research. 14:2154-2160

Purpose: To establish a severe combined immunodeficient (SCID)-hu in vivo mouse model of human primary mantle cell lymphoma (MCL) for the study of the biology and novel therapy of human MCL. Experimental Design: Primary MCL cells were isolated from s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2d9fe78b82e256cfecb6bb7007b7412
https://doi.org/10.1158/1078-0432.ccr-07-4409

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