Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Atin K Mandal"'
The stability and activity of CRAF kinase are stringently regulated by heat shock protein 90 (Hsp90). Hsp90-mediated client folding and maturation is governed by its co-chaperones, but their functionality in chaperoning CRAF/Raf1 kinase to accomplish
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f5198e4edb326ddcef35b2f24437505a
https://doi.org/10.1101/2023.02.17.528950
https://doi.org/10.1101/2023.02.17.528950
Autor:
Ranit Pariary, Sandip Dolui, Gourav Shome, Sk Abdul Mohid, Achintya Saha, Bhisma N Ratha, Amaravadhi Harikishore, Kuladip Jana, Atin K Mandal, Nakul Chandra Maiti, Anirban Bhunia
Publikováno v:
Chemical Communications.
Our studies show Coomassie Brilliant Blue G-250 as a promising chemical chaperone that stabilises the α-helical native human insulin conformers, disrupting its aggregation. Furthermore, it also increases the insulin secretion....
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c55c13d1a63880da00cc13e70ff4f871
https://doi.org/10.1039/d3cc01791e
https://doi.org/10.1039/d3cc01791e
Autor:
Monica Agnoletti, Mariena J. A. van der Plas, Sourav Kumar, Atin K. Mandal, Anirban Bhunia, Hanudatta S. Atreya, Humaira Ilyas, Martin Malmsten
Publikováno v:
Bioconjugate Chemistry. 32:1729-1741
Conjugation with poly(ethylene glycol) ("PEGylation") is a widely used approach for improving the therapeutic propensities of peptide and protein drugs through prolonging bloodstream circulation, reducing toxicity and immunogenicity, and improving pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::037ac66134bb1a9ccf9781fac936d313
https://doi.org/10.1021/acs.bioconjchem.1c00259
https://doi.org/10.1021/acs.bioconjchem.1c00259
Autor:
Anirban Ghosh, Bhisma Narayan Ratha, Nilanjan Gayen, Kamal H Mroue, Rajiv K Kar, Atin K Mandal, Anirban Bhunia
Publikováno v:
PLoS ONE, Vol 10, Iss 8, p e0135976 (2015)
Phosphorylation at the C-terminal flexible region of the C-Raf protein plays an important role in regulating its biological activity. Auto-phosphorylation at serine 621 (S621) in this region maintains C-Raf stability and activity. This phosphorylatio
Externí odkaz:
https://doaj.org/article/ecb6e25c43f345e296ce19a2bf36ebbd
Autor:
Rajiv K. Kar, Anirban Bhunia, Ipsita Chakraborty, D. Sarkar, Sourav Kumar, Atin K. Mandal, Nakul C. Maiti
Publikováno v:
ACS chemical neuroscience. 12(15)
Solvent dynamics strongly induce the fibrillation of an amyloidogenic system. Probing the solvation mechanism is crucial as it enables us to predict different proteins' functionalities, such as the aggregation propensity, structural flexibility, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d49179aa9dec33504f6525e644904d1b
https://pubmed.ncbi.nlm.nih.gov/34292711
https://pubmed.ncbi.nlm.nih.gov/34292711
Publikováno v:
Molecular Biology of the Cell
A network of chaperones and ubiquitin ligases sustain intracellular proteostasis, and is integral in preventing aggregation of misfolded proteins associated with various neurodegenerative diseases. Using cell-based studies of polyglutamine (polyQ) di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbc9749c2197a532e0671739ac3e1231
https://doi.org/10.1101/2020.12.13.417964
https://doi.org/10.1101/2020.12.13.417964
Autor:
Sk. Abdul Mohid, Anirban Bhunia, Janarthanan Krishnamoorthy, D. Sarkar, Dipita Bhattacharyya, Nilanjan Gayen, Atin K. Mandal, Dong Kuk Lee, Swapna Bera, Jihye Choi, Nirakar Sahoo
Publikováno v:
ACS chemical neuroscience. 11(13)
Alzheimer's disease (AD) is a severe neurodegenerative disorder caused by abnormal accumulation of toxic amyloid plaques of the amyloid-beta (Aβ) or the tau proteins in the brain. The plaque deposition leading to the collapse of the cellular integri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::989a6fec0341c201ff5f6532d63520ec
https://pubmed.ncbi.nlm.nih.gov/32492332
https://pubmed.ncbi.nlm.nih.gov/32492332
Autor:
Ranit Pariary, Dipita Bhattacharyya, Zuzana Bednarikova, Sreyan Raha, Atin K. Mandal, Zuzana Gazova, Kyriakos G. Varnava, Baijayanti Ghosh, Vijayalekshmi Sarojini, Bhisma N Ratha, Anirban Bhunia
Publikováno v:
Biochimica et biophysica acta. Proteins and proteomics. 1868(5)
Amyloidogenic disorders are currently rising as a global health issue, prompting more and more studies dedicated to the development of effective targeted therapeutics. The innate affinity of these amyloidogenic proteins towards the biomembranes adds
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdd1474a9b501efd330e2c76b0077208
https://pubmed.ncbi.nlm.nih.gov/32032759
https://pubmed.ncbi.nlm.nih.gov/32032759
Autor:
Bhisma N Ratha, Samir K. Maji, Ambuja Navalkar, Dipita Bhattacharyya, Kanchan Garai, Atin K. Mandal, Rakesh Kumar, Nilanjan Gayen, Anirban Ghosh, Surabhi Mehra, Janarthanan Krishnamoorthy, Samuel A. Kotler, Ganesh M. Mohite, Anirban Bhunia
Publikováno v:
ACS chemical neuroscience. 10(5)
Altered intestinal permeability has been correlated with Parkinson's pathophysiology in the enteric nervous system, before manifestations in the central nervous system (CNS). The inflammatory endotoxin or lipopolysaccharide (LPS) released by gut bact
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3a22d6b5dbcbe3857036f17b8aaaaa5
https://pubmed.ncbi.nlm.nih.gov/30855940
https://pubmed.ncbi.nlm.nih.gov/30855940
Publikováno v:
Journal of Biological Chemistry. 291:24579-24593
CRAF kinase maintains cell viability, growth, and proliferation by participating in the MAPK pathway. Unlike BRAF, CRAF requires continuous chaperoning by Hsp90 to retain MAPK signaling. However, the reason behind the continuous association of Hsp90
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f6cc0b17e3cd29cde6356a1e75ad8b7
https://doi.org/10.1074/jbc.m116.746420
https://doi.org/10.1074/jbc.m116.746420