T cell immune deficiency rather than chromosome instability predisposes patients with short telomere syndromes to squamous cancers.

Autor: Schratz KE; Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA; Telomere Center at Johns Hopkins, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA; Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA., Flasch DA; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA., Atik CC; Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA., Cosner ZL; Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA., Blackford AL; Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA; Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA., Yang W; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA., Gable DL; Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA., Vellanki PJ; Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA., Xiang Z; Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA., Gaysinskaya V; Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA., Vonderheide RH; Abramson Cancer Center, Perlman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA., Rooper LM; Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA; Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA., Zhang J; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA., Armanios M; Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA; Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA; Telomere Center at Johns Hopkins, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA; Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA. Electronic address: marmani1@jhmi.edu.

Publikováno v: Cancer cell [Cancer Cell] 2023 Apr 10; Vol. 41 (4), pp. 807-817.e6. Date of Electronic Publication: 2023 Apr 02.

Telomeres: Dysfunction, Maintenance, Aging and Cancer.

Autor: Pan Liao^1,2,3, Bo Yan^2,3, Conglin Wang^2,3, Ping Lei^1,2,3 leiping1974@163.com

Publikováno v: Aging & Disease. Nov2024, Vol. 15 Issue 6, p2595-2631. 37p.

ZCCHC8 , the nuclear exosome targeting component, is mutated in familial pulmonary fibrosis and is required for telomerase RNA maturation.

Autor: Gable DL; Medical Scientist Training Program, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.; Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA.; Telomere Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA., Gaysinskaya V; Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA.; Telomere Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA., Atik CC; Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA.; Telomere Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA., Talbot CC Jr; Institute for Basic Biomedical Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA., Kang B; Department of Comparative and Molecular Pathobiology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA., Stanley SE; Medical Scientist Training Program, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.; Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA.; Telomere Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA., Pugh EW; Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA., Amat-Codina N; Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA.; Telomere Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA., Schenk KM; Osler Medical Housestaff Training Program, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA., Arcasoy MO; Department of Medicine, Duke University School of Medicine, Durham, North Carolina 27708, USA., Brayton C; Department of Comparative and Molecular Pathobiology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA., Florea L; Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA., Armanios M; Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA.; Telomere Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA.; Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA.; Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA.

Publikováno v: Genes & development [Genes Dev] 2019 Oct 01; Vol. 33 (19-20), pp. 1381-1396. Date of Electronic Publication: 2019 Sep 05.

Investigating the association between blood metabolites and telomere length: A mendelian randomization study.

Autor: Gao, Chen¹ (AUTHOR) gaotjwk5122@163.com

Publikováno v: PLoS ONE. 3/8/2024, Vol. 19 Issue 3, p1-16. 16p.

Biological basis of extensive pleiotropy between blood traits and cancer risk.

Autor: Pardo-Cea, Miguel Angel¹ (AUTHOR), Farré, Xavier² (AUTHOR), Esteve, Anna³ (AUTHOR), Palade, Joanna⁴ (AUTHOR), Espín, Roderic¹ (AUTHOR), Mateo, Francesca¹ (AUTHOR), Alsop, Eric⁴ (AUTHOR), Alorda, Marc¹ (AUTHOR), Blay, Natalia² (AUTHOR), Baiges, Alexandra¹ (AUTHOR), Shabbir, Arzoo¹ (AUTHOR), Comellas, Francesc⁵ (AUTHOR), Gómez, Antonio⁶ (AUTHOR), Arnan, Montserrat⁷ (AUTHOR), Teulé, Alex⁸ (AUTHOR), Salinas, Monica⁸ (AUTHOR), Berrocal, Laura⁹ (AUTHOR), Brunet, Joan^8,9,10 (AUTHOR), Rofes, Paula^8,10 (AUTHOR), Lázaro, Conxi^8,10 (AUTHOR)

Publikováno v: Genome Medicine. 2/2/2024, Vol. 16 Issue 1, p1-22. 22p.