Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Atica, Moosa"'
Tuberculosis (TB) imposes a major burden on global public health which is exacerbated by the escalating number of multidrug-resistant (MDR)-TB cases. There is consequently an urgent need for new anti-TB drugs and combination regimens. We have investi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4c07ecaf8c84e348b769fa0e8345f183
https://doi.org/10.1101/2023.01.19.524834
https://doi.org/10.1101/2023.01.19.524834
Autor:
Timm O. Koller, Ullrich Scheid, Teresa Kösel, Jennifer Herrmann, Daniel Krug, Helena I. M. Boshoff, Bertrand Beckert, Joanna C. Evans, Jan Schlemmer, Becky Sloan, Danielle M. Weiner, Laura E. Via, Atica Moosa, Thomas R. Ioerger, Michael Graf, Boris Zinshteyn, Maha Abdelshahid, Fabian Nguyen, Stefan Arenz, Franziska Gille, Maik Siebke, Tim Seedorf, Oliver Plettenburg, Rachel Green, Anna-Luisa Warnke, Joachim Ullrich, Ralf Warrass, Clifton E. Barry, Digby F. Warner, Valerie Mizrahi, Andreas Kirschning, Daniel N. Wilson, Rolf Müller
Publikováno v:
Journal of the American Chemical Society.
Resistance of bacterial pathogens against antibiotics is declared by WHO as a major global health threat. As novel antibacterial agents are urgently needed, we re-assessed the broad-spectrum myxobacterial antibiotic myxovalargin and found it to be ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f61df24b5a4b0bbef748e3d2b650186
https://pubmed.ncbi.nlm.nih.gov/36603206
https://pubmed.ncbi.nlm.nih.gov/36603206
Autor:
Benjamin Patterson, Carl Morrow, Vinayak Singh, Atica Moosa, Melitta Gqada, Jeremy Woodward, Valerie Mizrahi, Wayne Bryden, Charles Call, Shwetak Patel, Digby Warner, Robin Wood
Publikováno v:
Gates Open Research, Vol 1 (2018)
Background: Tuberculosis (TB) is predominantly an airborne disease. However, quantitative and qualitative analysis of bio-aerosols containing the aetiological agent, Mycobacterium tuberculosis (Mtb), has proven very challenging. Our objective is to s
Externí odkaz:
https://doaj.org/article/477d4bde6e234d0eada8a272a90c395b
Autor:
Benjamin Patterson, Carl Morrow, Vinayak Singh, Atica Moosa, Melitta Gqada, Jeremy Woodward, Valerie Mizrahi, Wayne Bryden, Charles Call, Shwetak Patel, Digby Warner, Robin Wood
Publikováno v:
Gates Open Research, Vol 1 (2017)
Background: Tuberculosis (TB) is predominantly an airborne disease. However, quantitative and qualitative analysis of bio-aerosols containing the aetiological agent, Mycobacterium tuberculosis (Mtb), has proven very challenging. Our objective is to s
Externí odkaz:
https://doaj.org/article/1e4d2ea4a05b409a878bbf1e5340f0c9
Autor:
Timm O. Koller, Ullrich Scheid, Teresa Kösel, Jennifer Herrmann, Daniel Krug, Helena I. Boshoff, Bertrand Beckert, Joanna C. Evans, Jan Schlemmer, Becky Sloan, Danielle M. Weiner, Laura E. Via, Atica Moosa, Thomas R. Ioerger, Franziska Gille, Maik Siebke, Tim Seedorf, Oliver Plettenburg, Anna-Luisa Warnke, Joachim Ullrich, Ralf Warrass, Clifton E. Barry, Digby F. Warner, Valerie Mizrahi, Andreas Kirschning, Daniel N. Wilson, Rolf Müller
Resistance of bacterial pathogens against antibiotics is declared by WHO as a major global health threat. As novel antibacterial agents are urgently needed, we re-assessed the broad-spectrum myxobacterial antibiotic myxovalargin and found it to be ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c4f6c283c2b8195cb0e7617a3d4e5c55
https://doi.org/10.26434/chemrxiv-2022-vr3hn
https://doi.org/10.26434/chemrxiv-2022-vr3hn
Autor:
Ujjini H. Manjunatha, Christel Brunschwig, Mathew Njoroge, Srinivasa P. S. Rao, Nina Lawrence, Dale Taylor, Rudolf Müller, Kelly Chibale, Paul M. Njaria, Renier van der Westhuyzen, Vinayak Singh, Leslie J. Street, Amanda Mabhula, Atica Moosa, Digby F. Warner, Denis Ngumbu Muhunga, Paul W. Smith
Publikováno v:
Journal of Medicinal Chemistry. 64:9444-9457
Screening of a library of small polar molecules against Mycobacterium tuberculosis (Mtb) led to the identification of a potent benzoheterocyclic oxime carbamate hit series. This series was subjected to medicinal chemistry progression underpinned by s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f22b2b0b4cd9366307e089958a09622f
https://doi.org/10.1021/acs.jmedchem.1c00707
https://doi.org/10.1021/acs.jmedchem.1c00707
Autor:
Robin Wood, Carl Morrow, Clifton E Barry, Wayne A Bryden, Charles J Call, Anthony J Hickey, Charles E Rodes, Thomas J Scriba, Jonathan Blackburn, Chacha Issarow, Nicola Mulder, Jeremy Woodward, Atica Moosa, Vinayak Singh, Valerie Mizrahi, Digby F Warner
Publikováno v:
PLoS ONE, Vol 11, Iss 1, p e0146658 (2016)
Knowledge of the airborne nature of respiratory disease transmission owes much to the pioneering experiments of Wells and Riley over half a century ago. However, the mechanical, physiological, and immunopathological processes which drive the producti
Externí odkaz:
https://doaj.org/article/ba37c8384a6e451186fb68a770292e02
Autor:
Anthony J. Smith, Dale Taylor, Anne J. Lenaerts, Thomas R. Ioerger, Nina Lawrence, Kelly Chibale, Rudolf Mueller, Vinayak Singh, Claire Le Manach, Aloysius T. Nchinda, Alissa Myrick, Mathew Njoroge, Paul M. Njaria, Elizabeth J. Brooks, Atica Moosa, Jessica N. Akester, Gregory T. Robertson
Publikováno v:
ACS Infectious Diseases
Phenotypic whole-cell screening against Mycobacterium tuberculosis (Mtb) in glycerol-alanine-salts supplemented with Tween 80 and iron (GASTE-Fe) media led to the identification of a 2-aminoquinazolinone hit compound, sulfone 1 which was optimized fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae5442c3902e05983890e5f02f889b02
http://europepmc.org/articles/PMC7359024
http://europepmc.org/articles/PMC7359024
Autor:
Renier, van der Westhuyzen, Amanda, Mabhula, Paul M, Njaria, Rudolf, Müller, Denis, Ngumbu Muhunga, Dale, Taylor, Nina, Lawrence, Mathew, Njoroge, Christel, Brunschwig, Atica, Moosa, Vinayak, Singh, Srinivasa P S, Rao, Ujjini H, Manjunatha, Paul W, Smith, Digby F, Warner, Leslie J, Street, Kelly, Chibale
Publikováno v:
Journal of medicinal chemistry. 64(13)
Screening of a library of small polar molecules against
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::03d111d78c2e649bf21f94024eb5cf31
https://pubmed.ncbi.nlm.nih.gov/34138573
https://pubmed.ncbi.nlm.nih.gov/34138573
Autor:
Pooja Agarwal, Valerie Mizrahi, Atica Moosa, Antonina Wasuna, Thomas R. Ioerger, Kelly Chibale, Elizabeth Kigondu, Digby F. Warner, Vinayak Singh, Charles Onyango Omollo
Publikováno v:
Antimicrobial Agents and Chemotherapy
Tuberculosis (TB) is a leading global cause of mortality owing to an infectious agent, accounting for almost one-third of antimicrobial resistance (AMR) deaths annually. We aimed to identify synergistic anti-TB drug combinations with the capacity to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca3f68f490f037440440a96ae104e139
https://doi.org/10.1101/860288
https://doi.org/10.1101/860288