Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Athma A Pai"'
Publikováno v:
PLoS Genetics, Vol 14, Iss 8, p e1007588 (2018)
Recursive splicing, a process by which a single intron is removed from pre-mRNA transcripts in multiple distinct segments, has been observed in a small subset of Drosophila melanogaster introns. However, detection of recursive splicing requires obser
Externí odkaz:
https://doaj.org/article/d0908a0b30c34360be862b7909c81a92
Autor:
Athma A Pai, Telmo Henriques, Kayla McCue, Adam Burkholder, Karen Adelman, Christopher B Burge
Publikováno v:
eLife, Vol 6 (2017)
Production of most eukaryotic mRNAs requires splicing of introns from pre-mRNA. The splicing reaction requires definition of splice sites, which are initially recognized in either intron-spanning (‘intron definition’) or exon-spanning (‘exon de
Externí odkaz:
https://doaj.org/article/68b7f83da5c24e6d8e8a964d15ff0e17
Autor:
Allison L Richards, Donovan Watza, Anthony Findley, Adnan Alazizi, Xiaoquan Wen, Athma A Pai, Roger Pique-Regi, Francesca Luca
Publikováno v:
PLoS Genetics, Vol 13, Iss 10, p e1006995 (2017)
Environmental perturbations have large effects on both organismal and cellular traits, including gene expression, but the extent to which the environment affects RNA processing remains largely uncharacterized. Recent studies have identified a large n
Externí odkaz:
https://doaj.org/article/a5c77d8e2c664aacb435abf3d92f266b
Autor:
Athma A Pai, Golshid Baharian, Ariane Pagé Sabourin, Jessica F Brinkworth, Yohann Nédélec, Joseph W Foley, Jean-Christophe Grenier, Katherine J Siddle, Anne Dumaine, Vania Yotova, Zachary P Johnson, Robert E Lanford, Christopher B Burge, Luis B Barreiro
Publikováno v:
PLoS Genetics, Vol 12, Iss 9, p e1006338 (2016)
The contribution of pre-mRNA processing mechanisms to the regulation of immune responses remains poorly studied despite emerging examples of their role as regulators of immune defenses. We sought to investigate the role of mRNA processing in the cell
Externí odkaz:
https://doaj.org/article/3cffb7e4abef48b4bb26f9b2dd3b0a57
Publikováno v:
PLoS Genetics, Vol 11, Iss 1, p e1004857 (2015)
It is now well established that noncoding regulatory variants play a central role in the genetics of common diseases and in evolution. However, until recently, we have known little about the mechanisms by which most regulatory variants act. For insta
Externí odkaz:
https://doaj.org/article/7b64a98d838a49229e6b439362eafd00
Autor:
Daniel J Gaffney, Graham McVicker, Athma A Pai, Yvonne N Fondufe-Mittendorf, Noah Lewellen, Katelyn Michelini, Jonathan Widom, Yoav Gilad, Jonathan K Pritchard
Publikováno v:
PLoS Genetics, Vol 8, Iss 11, p e1003036 (2012)
Nucleosomes are important for gene regulation because their arrangement on the genome can control which proteins bind to DNA. Currently, few human nucleosomes are thought to be consistently positioned across cells; however, this has been difficult to
Externí odkaz:
https://doaj.org/article/5b78bdfd51d64f39811400796afe497f
Autor:
Athma A Pai, Carolyn E Cain, Orna Mizrahi-Man, Sherryl De Leon, Noah Lewellen, Jean-Baptiste Veyrieras, Jacob F Degner, Daniel J Gaffney, Joseph K Pickrell, Matthew Stephens, Jonathan K Pritchard, Yoav Gilad
Publikováno v:
PLoS Genetics, Vol 8, Iss 10, p e1003000 (2012)
Recent gene expression QTL (eQTL) mapping studies have provided considerable insight into the genetic basis for inter-individual regulatory variation. However, a limitation of all eQTL studies to date, which have used measurements of steady-state gen
Externí odkaz:
https://doaj.org/article/c69b7c8ae4b0425bb920406453041bfa
Publikováno v:
PLoS Genetics, Vol 7, Iss 2, p e1001316 (2011)
The modification of DNA by methylation is an important epigenetic mechanism that affects the spatial and temporal regulation of gene expression. Methylation patterns have been described in many contexts within and across a range of species. However,
Externí odkaz:
https://doaj.org/article/a2397f3d4ccc4b79979283348590a733
Autor:
Klara Stefflova, Matthew C Dulik, Jill S Barnholtz-Sloan, Athma A Pai, Amy H Walker, Timothy R Rebbeck
Publikováno v:
PLoS ONE, Vol 6, Iss 1, p e14495 (2011)
The ancestry of African-descended Americans is known to be drawn from three distinct populations: African, European, and Native American. While many studies consider this continental admixture, few account for the genetically distinct sources of ance
Externí odkaz:
https://doaj.org/article/9abc33a74fd54bde834e5d0bae71b579
Publikováno v:
PLoS Genetics, Vol 6, Iss 12, p e1001236 (2010)
While the majority of multiexonic human genes show some evidence of alternative splicing, it is unclear what fraction of observed splice forms is functionally relevant. In this study, we examine the extent of alternative splicing in human cells using
Externí odkaz:
https://doaj.org/article/53a0cd2769884da89f0fad3e2c135bbc