Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Athina G. Portaliou"'
Autor:
Srinath Krishnamurthy, Marios-Frantzeskos Sardis, Nikolaos Eleftheriadis, Katerina E. Chatzi, Jochem H. Smit, Konstantina Karathanou, Giorgos Gouridis, Athina G. Portaliou, Ana-Nicoleta Bondar, Spyridoula Karamanou, Anastassios Economou
Publikováno v:
Cell Reports, Vol 38, Iss 6, Pp 110346- (2022)
Summary: Protein machines undergo conformational motions to interact with and manipulate polymeric substrates. The Sec translocase promiscuously recognizes, becomes activated, and secretes >500 non-folded preprotein clients across bacterial cytoplasm
Externí odkaz:
https://doaj.org/article/bdd7e0f8f72b43d599e95709a51696f3
Autor:
Luit Barkalita, Athina G. Portaliou, Maria S. Loos, Biao Yuan, Spyridoula Karamanou, Anastassios Economou
Publikováno v:
Microorganisms, Vol 8, Iss 11, p 1786 (2020)
The type 3 secretion system is essential for pathogenesis of several human and animal Gram-negative bacterial pathogens. The T3SS comprises a transmembrane injectisome, providing a conduit from the bacterial cytoplasm to the host cell cytoplasm for t
Externí odkaz:
https://doaj.org/article/f5c49949d5b14d869ca7bab8e5e2c828
Autor:
Li Chen, Xuanjun Ai, Athina G. Portaliou, Conceicao A.S.A. Minetti, David P. Remeta, Anastassios Economou, Charalampos G. Kalodimos
Publikováno v:
Cell Reports, Vol 3, Iss 3, Pp 709-715 (2013)
The targeting of type III secretion (TTS) proteins at the injectisome is an important process in bacterial virulence. Nevertheless, how the injectisome specifically recognizes TTS substrates among all bacterial proteins is unknown. A TTS peripheral m
Externí odkaz:
https://doaj.org/article/5746b875158e4df590f9d0789ac7dc46
Autor:
Dries Smets, Alexandra Tsirigotaki, Jochem H Smit, Srinath Krishnamurthy, Athina G Portaliou, Anastassia Vorobieva, Wim Vranken, Spyridoula Karamanou, Anastassios Economou
Secretory preproteins of the Sec pathway are targeted post-translationally and cross cellular membranes through translocases. During cytoplasmic transit, mature domains remain non-folded for translocase recognition/translocation. After translocation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5864da46789a9a80208e8e6ffd39962
https://doi.org/10.15252/embj.2022111344
https://doi.org/10.15252/embj.2022111344
Autor:
Dries Smets, Alexandra Tsirigotaki, Jochem H. Smit, Srinath Krishnamurthy, Athina G. Portaliou, Anastassia Vorobieva, Wim Vranken, Spyridoula Karamanou, Anastassios Economou
Secretory preproteins of the Sec pathway bear signal peptides and are targeted post-translationally to cross the plasma membrane or ER through translocases. After translocation and signal peptide cleavage, mature domains fold to native states in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::921c199a5bbbecfced83fb928c07e6ae
https://biblio.vub.ac.be/vubir/evolutionary-adaptation-of-the-folding-pathway-for-secretability(63db8fe6-869d-4733-b221-1127bde1ea67).html
https://biblio.vub.ac.be/vubir/evolutionary-adaptation-of-the-folding-pathway-for-secretability(63db8fe6-869d-4733-b221-1127bde1ea67).html
Autor:
Athina G. Portaliou
Το σύστημα έκκρισης τύπου ΙΙΙ (Τ3SS) είναι ένα ευρεία διαδεδομένο σύστημα που χρησιμοποιείται από πολλά παθογόνα, κατά Gram αρνητικά βακτήρ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c9859594679ec239cb56edea027040da
https://doi.org/10.12681/eadd/35417
https://doi.org/10.12681/eadd/35417
Autor:
Spyridoula Karamanou, Maria S Loos, Anastassios Economou, Luit Moni Barkalita, Athina G. Portaliou, Biao Yuan
Publikováno v:
Microorganisms
Volume 8
Issue 11
Microorganisms, Vol 8, Iss 1786, p 1786 (2020)
Volume 8
Issue 11
Microorganisms, Vol 8, Iss 1786, p 1786 (2020)
The type 3 secretion system is essential for pathogenesis of several human and animal Gram-negative bacterial pathogens. The T3SS comprises a transmembrane injectisome, providing a conduit from the bacterial cytoplasm to the host cell cytoplasm for t
Autor:
Spyridoula Karamanou, Bindu Y. Srinivasu, Jozefien De Geyter, Athina G. Portaliou, Anastassios Economou, Srinath Krishnamurthy
Publikováno v:
EMBO Rep
Bacterial secretory preproteins are translocated across the inner membrane post-translationally by the SecYEG-SecA translocase. Mature domain features and signal peptides maintain preproteins in kinetically trapped, largely soluble, folding intermedi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80cd963b465c8b1b68e57ddc356df0e6
https://europepmc.org/articles/PMC7271322/
https://europepmc.org/articles/PMC7271322/
Autor:
Yichen Li, Franck Duong Van Hoa, Harveer Singh Dhupar, Maria S Loos, Rinky Parakra, Anastassios Economou, Jiri Wald, Biao Yuan, Athina G. Portaliou, Spyridoula Karamanou, Thomas C. Marlovits, Charalampos G. Kalodimos, Jochem H. Smit, Thorben Cordes, Bindu Y. Srinivasu, Dirk Fahrenkamp
Publikováno v:
Journal of Molecular Biology, 433(21):167188. Academic Press
Type III protein secretion is widespread in Gram-negative pathogens. It comprises the injectisome with a surface-exposed needle and an inner membrane translocase. The translocase contains the SctRSTU export channel enveloped by the export gate subuni
Autor:
Athina G. Portaliou, Giorgos Gouridis, Srinath Krishnamurthy, Ana-Nicoleta Bondar, Anastassios Economou, Konstantina Karathanou, Jochem H. Smit, Katerina E. Chatzi, Nikolaos Eleftheriadis, Spyridoula Karamanou
Publikováno v:
Structure. 29:846-858.e7
SummaryThe cytoplasmic ATPase SecA and the membrane-embedded SecYEG channel assemble to form the functional Sec translocase. How this interaction primes and catalytically activates the translocase remains unclear. We now show that priming exploits a