Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Athina Ganner"'
Publikováno v:
Journal of Kidney Cancer and VHL, Vol 11, Iss 1 (2024)
The von Hippel-Lindau tumor suppressor gene (VHL) is mutated in up to 90% of clear cell renal cell carcinoma (ccRCC) cases, thus playing a key role in ccRCC pathogenesis. ccRCC can be classified as a metabolic disease in which alterations in fatty ac
Externí odkaz:
https://doaj.org/article/fecdfcc0903b4799a6b0fd759c92f0c0
Autor:
Thomas Welte, Frederic Arnold, Lukas Westermann, Felix A. Rottmann, Martin J. Hug, Elke Neumann-Haefelin, Athina Ganner
Publikováno v:
BMC Nephrology, Vol 24, Iss 1, Pp 1-9 (2023)
Abstract Background C3 Glomerulopathy (C3G) is a rare glomerular disease caused by dysregulation of the complement pathway. Based on its pathophysiology, treatment with the monoclonal antibody eculizumab targeting complement C5 may be a therapeutic o
Externí odkaz:
https://doaj.org/article/d698782c82b94a038f38014bb9e2347d
Autor:
Athina Ganner, Christina Gehrke, Marinella Klein, Lena Thegtmeier, Tanja Matulenski, Laura Wingendorf, Lu Wang, Felicitas Pilz, Lars Greidl, Lisa Meid, Fruzsina Kotsis, Gerd Walz, Ian J. Frew, Elke Neumann-Haefelin
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract Inactivation of the tumor suppressor von Hippel–Lindau (VHL) gene is a key event in hereditary and sporadic clear cell renal cell carcinomas (ccRCC). The mechanistic target of rapamycin (mTOR) signaling pathway is a fundamental regulator o
Externí odkaz:
https://doaj.org/article/241005f7df754cd8bd98e91ced3ed44d
Autor:
Daniel A. Mohl, Simon Lagies, Kyra Zodel, Matthias Zumkeller, Asin Peighambari, Athina Ganner, Dietmar A. Plattner, Elke Neumann-Haefelin, Mojca Adlesic, Ian J. Frew, Bernd Kammerer
Publikováno v:
Cells, Vol 12, Iss 8, p 1102 (2023)
Clear cell renal cell carcinoma (ccRCC) accounts for ~75% of kidney cancers. The biallelic inactivation of the von Hippel–Lindau tumor suppressor gene (VHL) is the truncal driver mutation of most cases of ccRCC. Cancer cells are metabolically repro
Externí odkaz:
https://doaj.org/article/c14feeae9dc44cb78d95daac398001d5
Autor:
Athina Ganner, Antonia Philipp, Simon Lagies, Laura Wingendorf, Lu Wang, Felicitas Pilz, Thomas Welte, Kelli Grand, Soeren S. Lienkamp, Marinella Klein, Bernd Kammerer, Ian J. Frew, Gerd Walz, Elke Neumann-Haefelin
Publikováno v:
Cells, Vol 12, Iss 6, p 835 (2023)
Clear cell renal cell carcinoma (ccRCC) is the most common histological subtype of renal cancer, and inactivation of the VHL tumor suppressor gene is found in almost all cases of hereditary and sporadic ccRCCs. CcRCC is associated with the reprogramm
Externí odkaz:
https://doaj.org/article/b0fde4aca05f4c8a94fede21fde25ff8
Autor:
Amandine Viau, Gerd Walz, Esben Lorentzen, Heike Janusch, Athina Ganner, Fruzsina Kotsis, Albrecht Kramer-Zucker, Christopher Boehlke, Roland Nitschke, Daniel Epting, Yujie Li, Elke Neumann-Haefelin, E. Wolfgang Kuehn
Publikováno v:
Kotsis, F, Janusch, H, Li, Y, Viau, A, Epting, D, Kramer-Zucker, A, Walz, G, Nitschke, R, Lorentzen, E, Ganner, A, Neumann-Haefelin, E, Kuehn, E W & Boehlke, C 2021, ' Ift88, but not Kif3a, is required for establishment of the periciliary membrane compartment ', Biochemical and Biophysical Research Communications, vol. 584, pp. 19-25 . https://doi.org/10.1016/j.bbrc.2021.10.075
The primary cilium is a sensory organelle at the cell surface with integral functions in cell signaling. It contains a microtubular axoneme that is rooted in the basal body (BB) and serves as a scaffold for the movement of intraflagellar transport (I
Autor:
Christina Langhorst, Eric Peter Prager, Johanna Schneider, Gerd Walz, Bernd Jänigen, Stefan Zschiedrich, Athina Ganner, Przemyslaw Pisarski
Publikováno v:
Transplantation Proceedings. 53:848-855
Background ABO-incompatible kidney transplantation (ABOi-KT) is an established way to enlarge the donor pool around the world. Comparability of long-term success and complications to ABO-compatible kidney transplantation (ABOc-KT) are still under deb
Autor:
Athina Ganner, Gerd Walz, Zazie-Charlotte Pfeiffer, Saskia Kreis, Elke Neumann-Haefelin, Marinella Klein, Laura Wingendorf
Publikováno v:
Biochemical and Biophysical Research Communications. 524:895-902
The transcription factor NRF2 plays a key role in the protection against environmental stress and maintaining cellular homeostasis. The acetyltransferase p300 is a known component of the NRF2 transcriptional complex and promotes its transcriptional a
Autor:
Ralf Baumeister, Thomas Jank, Julia Gerber, Gerd Walz, Marinella Klein, Manuel Grafe, Sandra Finkbeiner, Jakob Kandzia, Athina Ganner, Kathrin Thedieck, Gerhard Breves, Elke Neumann-Haefelin, Antje Thien, Yujie Li
Publikováno v:
Oncotarget
// Yujie Li 1, * , Sandra Finkbeiner 1, * , Athina Ganner 1 , Julia Gerber 1, 9 , Marinella Klein 1 , Manuel Grafe 1 , Jakob Kandzia 1 , Antje Thien 1, 2 , Kathrin Thedieck 2, 3, 4 , Gerhard Breves 9 , Thomas Jank 5 , Ralf Baumeister 2, 6, 7, 8 , Ger
Autor:
Julia Gerber, Saskia Kreis, Gerhard Breves, Elke Neumann-Haefelin, Anna-Katharina Ziegler, Athina Ganner, Gerd Walz, Marinella Klein, Yujie Li, Tanja Matulenski, Jakob Kandzia
Publikováno v:
Experimental gerontology. 126
SKN-1/Nrf transcription factors regulate diverse biological processes essentially stress defense, detoxification, and longevity. Studies in model organisms have identified a broad range of regulatory processes and mechanisms that profoundly influence