Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Athilakshmi Kannan"'
Publikováno v:
iScience, Vol 26, Iss 7, Pp 107028- (2023)
Summary: Maternal uterine remodeling facilitates embryo implantation, stromal cell decidualization and placentation, and perturbation of these processes may cause pregnancy loss. Enhancer of zeste homolog 2 (EZH2) is a histone methyltransferase that
Externí odkaz:
https://doaj.org/article/e60d505507c644da9f0181cba3e94e6b
Autor:
Athilakshmi Kannan, Juanmahel Davila, Liying Gao, Saniya Rattan, Jodi A. Flaws, Milan K. Bagchi, Indrani C. Bagchi
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Di(2-ethylhexyl) phthalate (DEHP) is a synthetic chemical commonly used for its plasticizing capabilities. Because of the extensive production and use of DEHP, humans are exposed to this chemical daily. Diet is a significant exposure pathway
Externí odkaz:
https://doaj.org/article/df61d3b7e2b943d081855f38e81406b4
Autor:
Janelle Mapes, Quanxi Li, Athilakshmi Kannan, Lavanya Anandan, Mary Laws, John P Lydon, Indrani C Bagchi, Milan K Bagchi
Publikováno v:
PLoS Genetics, Vol 13, Iss 3, p e1006654 (2017)
In the mammary gland, genetic circuits controlled by estrogen, progesterone, and prolactin, act in concert with pathways regulated by members of the epidermal growth factor family to orchestrate growth and morphogenesis during puberty, pregnancy and
Externí odkaz:
https://doaj.org/article/e30b7bc014dc4529ad0542f829f87b1b
Autor:
Yanfen Li, Malavika K Adur, Athilakshmi Kannan, Juanmahel Davila, Yuechao Zhao, Romana A Nowak, Milan K Bagchi, Indrani C Bagchi, Quanxi Li
Publikováno v:
PLoS ONE, Vol 11, Iss 10, p e0165347 (2016)
Endometriosis, defined as growth of the endometrial cells outside the uterus, is an inflammatory disorder that is associated with chronic pelvic pain and infertility in women of childbearing age. Although the estrogen-dependence of endometriosis is w
Externí odkaz:
https://doaj.org/article/30bdc5fbfa13498d95f0e28ba6f4594d
Autor:
Juanmahel Davila, Mary J Laws, Athilakshmi Kannan, Quanxi Li, Robert N Taylor, Milan K Bagchi, Indrani C Bagchi
Publikováno v:
PLoS Genetics, Vol 11, Iss 8, p e1005458 (2015)
During placenta development, a succession of complex molecular and cellular interactions between the maternal endometrium and the developing embryo ensures reproductive success. The precise mechanisms regulating this maternal-fetal crosstalk remain u
Externí odkaz:
https://doaj.org/article/82edbb16aafd4dca91f030a6f425e214
Autor:
Mary J Laws, Athilakshmi Kannan, Sandeep Pawar, Wanda M Haschek, Milan K Bagchi, Indrani C Bagchi
Publikováno v:
PLoS Genetics, Vol 10, Iss 3, p e1004230 (2014)
The etiology of ovarian epithelial cancer is poorly understood, mainly due to the lack of an appropriate experimental model for studying the onset and progression of this disease. We have created a mutant mouse model in which aberrant estrogen recept
Externí odkaz:
https://doaj.org/article/6ea3444ee9a64927bf935cfac331e1ca
Autor:
Allison Jones, Andrew E Teschendorff, Quanxi Li, Jane D Hayward, Athilakshmi Kannan, Tim Mould, James West, Michal Zikan, David Cibula, Heidi Fiegl, Shih-Han Lee, Elisabeth Wik, Richard Hadwin, Rupali Arora, Charlotte Lemech, Henna Turunen, Päivi Pakarinen, Ian J Jacobs, Helga B Salvesen, Milan K Bagchi, Indrani C Bagchi, Martin Widschwendter
Publikováno v:
PLoS Medicine, Vol 10, Iss 11, p e1001551 (2013)
BackgroundEndometrial cancer incidence is continuing to rise in the wake of the current ageing and obesity epidemics. Much of the risk for endometrial cancer development is influenced by the environment and lifestyle. Accumulating evidence suggests t
Externí odkaz:
https://doaj.org/article/73703b4583b84fbbbd4a043f8172571e
Autor:
Qiuyan Ma, Jacob R. Beal, Arpita Bhurke, Athilakshmi Kannan, Jie Yu, Robert N. Taylor, Indrani C. Bagchi, Milan K. Bagchi
Publikováno v:
Proceedings of the National Academy of Sciences. 119
In humans, the uterus undergoes a dramatic transformation to form an endometrial stroma-derived secretory tissue, termed decidua, during early pregnancy. The decidua secretes various factors that act in an autocrine/paracrine manner to promote stroma
Autor:
Qiuyan Ma, Indrani C. Bagchi, Alison M. Neff, Mary J. Laws, Robert N. Taylor, Athilakshmi Kannan, Arpita Bhurke, Milan K. Bagchi
Publikováno v:
Proc Natl Acad Sci U S A
Implantation is initiated when an embryo attaches to the uterine luminal epithelium and subsequently penetrates into the underlying stroma to firmly embed in the endometrium. These events are followed by the formation of an extensive vascular network
Autor:
Vijay K. Sirohi, Athilakshmi Kannan, Paul S. Cooke, Theresa I. Medrano, Indrani C. Bagchi, Ana M Mesa
Publikováno v:
Endocrinology
17β-estradiol (E2) treatment of ovariectomized adult mice stimulates the uterine PI3K-AKT signaling pathway and epithelial proliferation through estrogen receptor 1 (ESR1). However, epithelial proliferation occurs independently of E2/ESR1 signaling