DNA methylation profiling implicates exposure to PCBs in the pathogenesis of B-cell chronic lymphocytic leukemia

Autor: Georgiadis, P, Gavriil, M, Rantakokko, P, Ladoukakis, E, Botsivali, M, Kelly, RS, Bergdahl, IA, Kiviranta, H, Vermeulen, RCH, Spaeth, F, Hebbels, DGAJ, Kleinjans, JCS, de Kok, TMCM, Palli, D, Vineis, P, Kyrtopoulos, SA, Gottschalk, R, van Leeuwen, D, Timmermans, L, Bendinelli, B, Portengen, L, Saberi-Hosnijeh, F, Melin, B, Hallmans, G, Lenner, P, Keun, HC, Siskos, A, Athersuch, TJ, Kogevinas, M, Stephanou, EG, Myridakis, A, Fazzo, L, De Santis, M, Comba, P, Airaksinen, R, Ruokojärvi, P, Gilthorpe, M, Fleming, S, Fleming, T, Tu, Y-K, Jonsson, B, Lundh, T, Chen, WJ, Lee, W-C, Hsiao, CK, Chien, K-L, Kuo, P-H, Hung, H, Liao, S-F, EnviroGenomarkers consortium

Objectives: To characterize the impact of PCB exposure on DNA methylation in peripheral blood leucocytes and to evaluate the corresponding changes in relation to possible health effects, with a focus on B-cell lymphoma. Methods: We conducted an epige

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::49e1f1ab4e00a199669c2f90a8538980
https://eprints.whiterose.ac.uk/145459/1/1-s2.0-S0160412018325868-main.pdf

Performance in Omics Analyses of Blood Samples in Long-Term Storage: Opportunities for the Exploitation of Existing Biobanks in Environmental Health Research

Autor: Hebels DG, Georgiadis P, Keun HC, Athersuch TJ, Vineis P, Vermeulen R, Portengen L, Bergdahl IA, Hallmans G, Palli D, Bendinelli B, Krogh V, Tumino R, Sacerdote C, Kleinjans JC, de Kok TM, Smith MT, Kyrtopoulos SA, EnviroGenomarkers Project Consortium, PANICO, SALVATORE

Publikováno v: Environmental Health Perspectives
Environmental Health Perspectives, 121(4), 480-487. U.S. Department of Health and Human Services; National Institute of Environmental Health Sciences

Background: The suitability for omic analysis of biosamples collected in previous decades and currently stored in biobanks is unknown. Objectives: We evaluated the influence of handling and storage conditions of blood-derived biosamples on transcript

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8604e52b0a7687ac082b0221ff197395
https://cris.maastrichtuniversity.nl/en/publications/5d1dbaf8-357e-4918-87c7-b44a1853f60d

Omics for prediction of environmental health effects: Blood leukocyte-based cross-omic profiling reliably predicts diseases associated with tobacco smoking

Autor: Georgiadis, P, Hebels, DG, Valavanis, I, Liampa, I, Bergdahl, IA, Johansson, A, Palli, D, Chadeau-Hyam, M, Chatziioannou, A, Jennen, DGJ, Krauskopf, J, Jetten, MJ, Kleinjans, JCS, Vineis, P, Kyrtopoulos, SA, Gottschalk, R, Van Leeuwen, D, Timmermans, L, De Kok, TMCM, Botsivali, M, Bendinelli, B, Kelly, R, Vermeulen, R, Portengen, L, Saberi-Hosnijeh, F, Melin, B, Hallmans, G, Lenner, P, Keun, HC, Siskos, A, Athersuch, TJ, Kogevinas, M, Stephanou, EG, Myridakis, A, Fazzo, L, De Santis, M, Comba, P, Kiviranta, H, Rantakokko, P, Airaksinen, R, Ruokojärvi, P, Gilthorpe, M, Fleming, S, Fleming, T, Tu, YK, Jonsson, B, Lundh, T, Chen, WJ, Lee, WC, Hsiao, CK, Chien, KL, Kuo, PH, Hung, H, Liao, SF

The utility of blood-based omic profiles for linking environmental exposures to their potential health effects was evaluated in 649 individuals, drawn from the general population, in relation to tobacco smoking, an exposure with well-characterised he

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::ff83cc193be880677e1da5d756f1ea00
https://eprints.whiterose.ac.uk/109631/1/srep20544.pdf

A combination of transcriptomics and metabolomics uncovers enhanced bile acid biosynthesis in HepG2 cells expressing CCAAT/enhancer-binding protein ß (C/EBPß), hepatocyte nuclear factor 4a (HNF4a), and constitutive androstane receptor (CAR)

Autor: Blazquez M, Carretero A, Ellis JK, Athersuch TJ, Cavill R, Ebbels TM, Keun HC, Castell JV, Lahoz A, Bort R

Publikováno v: JOURNAL OF PROTEOME RESEARCH
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
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The development of hepatoma-based in vitro models to study hepatocyte physiology is an invaluable tool for both industry and academia. Here, we develop an in vitro model based on the HepG2 cell line that produces chenodeoxycholic acid, the main bile

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=RECOLECTA___::3b1dc158645aff238e2c088fb84843a6
https://fundanet.iislafe.san.gva.es/publicaciones/ProdCientif/PublicacionFrw.aspx?id=4477

Transacylation and hydrolysis of the acyl glucuronides of ibuprofen and its α-methyl-substituted analogues investigated by ¹ H NMR spectroscopy and computational chemistry: Implications for drug design.

Autor: Richards SE; Department of Chemistry, Khalifa University, Abu Dhabi, United Arab Emirates., Bradshaw PR; Department of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London, Burlington Danes Building, London W12 0NN, UK., Johnson CH; Department of Environmental Health Sciences, Yale School of Public Health, 60 College Street, New Haven, CT 06520-8034, USA., Stachulski AV; Department of Chemistry, The Robert Robinson Laboratories, University of Liverpool, Liverpool L69 7ZD, UK., Athersuch TJ; Department of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London, Burlington Danes Building, London W12 0NN, UK., Nicholson JK; The Australian National Phenome Centre and Computational and Systems Medicine, Health Futures Institute, Murdoch University, Harry Perkins Building, Perth WA6150, Australia; Institute of Global Health Innovation, Faculty of Medicine, Imperial College London, Level 1, Faculty Building, South Kensington Campus, London SW7 2NA, UK., Lindon JC; Department of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London, Burlington Danes Building, London W12 0NN, UK., Wilson ID; Department of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London, Burlington Danes Building, London W12 0NN, UK. Electronic address: i.wilson@imperial.ac.uk.

Publikováno v: Journal of pharmaceutical and biomedical analysis [J Pharm Biomed Anal] 2024 Aug 15; Vol. 246, pp. 116238. Date of Electronic Publication: 2024 May 20.