Therapeutic efficacy of IL-17A neutralization with corticosteroid treatment in a model of antigen-driven mixed-granulocytic asthma

Autor: Menson KE, Mank MM, Reed LF, Walton CJ, Van Der Vliet KE, Ather JL, Chapman DG, Smith BJ, Rincon M, Poynter ME

Many mouse models of allergic asthma exhibit eosinophil-predominant cellularity rather than the mixed-granulocytic cytology in steroid-unresponsive severe disease. Therefore, we sought to implement a novel mouse model of antigen-driven, mixed-granulo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______363::02893f21161b7b1ee250429cff045ee8
https://hdl.handle.net/10453/143389

Nuclear factor-kappaB activation in airway epithelium induces inflammation and hyperresponsiveness.

Autor: Pantano C, Ather JL, Alcorn JF, Poynter ME, Brown AL, Guala AS, Beuschel SL, Allen GB, Whittaker LA, Bevelander M, Irvin CG, Janssen-Heininger YM, Pantano, Cristen, Ather, Jennifer L, Alcorn, John F, Poynter, Matthew E, Brown, Amy L, Guala, Amy S, Beuschel, Stacie L, Allen, Gilman B

Publikováno v: American Journal of Respiratory & Critical Care Medicine; 5/1/2008, Vol. 177 Issue 9, p959-969, 11p

LncRNA U90926 is dispensable for the development of obesity-associated phenotypes in vivo.

Autor: Sabikunnahar B; Department of Biomedical and Health Sciences, University of Vermont, Burlington, Vermont, USA., Caldwell S; Department of Biomedical and Health Sciences, University of Vermont, Burlington, Vermont, USA., Varnum S; Department of Biomedical and Health Sciences, University of Vermont, Burlington, Vermont, USA., Hogan T; Department of Biomedical and Health Sciences, University of Vermont, Burlington, Vermont, USA., Lahue KG; Department of Biomedical and Health Sciences, University of Vermont, Burlington, Vermont, USA., Rathkolb B; Institute of Experimental Genetics and German Mouse Clinic, Helmholtz Zentrum München, Neuherberg, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany.; Institute of Molecular Animal Breeding and Biotechnology, Gene Center, Ludwig-Maximilians-University München, Munich, Germany., Gerlini R; Institute of Experimental Genetics and German Mouse Clinic, Helmholtz Zentrum München, Neuherberg, Germany., Dragano NRV; Institute of Experimental Genetics and German Mouse Clinic, Helmholtz Zentrum München, Neuherberg, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany., Aguilar-Pimentel A; Institute of Experimental Genetics and German Mouse Clinic, Helmholtz Zentrum München, Neuherberg, Germany., Irmler M; Institute of Experimental Genetics and German Mouse Clinic, Helmholtz Zentrum München, Neuherberg, Germany., Sanz-Moreno A; Institute of Experimental Genetics and German Mouse Clinic, Helmholtz Zentrum München, Neuherberg, Germany., da Silva-Buttkus P; Institute of Experimental Genetics and German Mouse Clinic, Helmholtz Zentrum München, Neuherberg, Germany., Beckers J; Institute of Experimental Genetics and German Mouse Clinic, Helmholtz Zentrum München, Neuherberg, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany.; TUM School of Life Sciences, Technische Universität München, Freising, Germany., Wolf E; Institute of Molecular Animal Breeding and Biotechnology, Gene Center, Ludwig-Maximilians-University München, Munich, Germany., Gailus-Durner V; Institute of Experimental Genetics and German Mouse Clinic, Helmholtz Zentrum München, Neuherberg, Germany., Fuchs H; Institute of Experimental Genetics and German Mouse Clinic, Helmholtz Zentrum München, Neuherberg, Germany., Hrabe de Angelis M; Institute of Experimental Genetics and German Mouse Clinic, Helmholtz Zentrum München, Neuherberg, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany.; TUM School of Life Sciences, Technische Universität München, Freising, Germany., Ather JL; Department of Medicine, University of Vermont, Burlington, Vermont, USA., Poynter ME; Department of Medicine, University of Vermont, Burlington, Vermont, USA., Krementsov DN; Department of Biomedical and Health Sciences, University of Vermont, Burlington, Vermont, USA.

Publikováno v: Physiological reports [Physiol Rep] 2024 Jan; Vol. 12 (1), pp. e15901.

Diet-induced obesity worsens allergen-induced type 2/type 17 inflammation in airways by enhancing DUOX1 activation.

Autor: Habibovic A; Departments of Pathology and Laboratory Medicine, Larner College of Medicine, University of Vermont, Burlington, Vermont., Hristova M; Departments of Pathology and Laboratory Medicine, Larner College of Medicine, University of Vermont, Burlington, Vermont., Morris CR; Departments of Pathology and Laboratory Medicine, Larner College of Medicine, University of Vermont, Burlington, Vermont.; Department of Medicine, Larner College of Medicine, University of Vermont, Burlington, Vermont., Lin MJ; Departments of Pathology and Laboratory Medicine, Larner College of Medicine, University of Vermont, Burlington, Vermont., Cruz LC; Departments of Pathology and Laboratory Medicine, Larner College of Medicine, University of Vermont, Burlington, Vermont., Ather JL; Department of Medicine, Larner College of Medicine, University of Vermont, Burlington, Vermont., Geiszt M; Department of Physiology and 'Lendület' Peroxidase Enzyme Research Group, Semmelweis University, Budapest, Hungary., Anathy V; Departments of Pathology and Laboratory Medicine, Larner College of Medicine, University of Vermont, Burlington, Vermont., Janssen-Heininger YMW; Departments of Pathology and Laboratory Medicine, Larner College of Medicine, University of Vermont, Burlington, Vermont., Poynter ME; Department of Medicine, Larner College of Medicine, University of Vermont, Burlington, Vermont., Dixon AE; Department of Medicine, Larner College of Medicine, University of Vermont, Burlington, Vermont., van der Vliet A; Departments of Pathology and Laboratory Medicine, Larner College of Medicine, University of Vermont, Burlington, Vermont.

Publikováno v: American journal of physiology. Lung cellular and molecular physiology [Am J Physiol Lung Cell Mol Physiol] 2023 Feb 01; Vol. 324 (2), pp. L228-L242. Date of Electronic Publication: 2023 Jan 10.

Macrophage-intrinsic DUOX1 contributes to type 2 inflammation and mucus metaplasia during allergic airway disease.

Autor: Morris CR; Department of Pathology and Laboratory Medicine, Larner College of Medicine, University of Vermont, Burlington, USA., Habibovic A; Department of Pathology and Laboratory Medicine, Larner College of Medicine, University of Vermont, Burlington, USA., Dustin CM; Department of Pathology and Laboratory Medicine, Larner College of Medicine, University of Vermont, Burlington, USA., Schiffers C; Department of Pathology and Laboratory Medicine, Larner College of Medicine, University of Vermont, Burlington, USA., Lin MC; Department of Pathology and Laboratory Medicine, Larner College of Medicine, University of Vermont, Burlington, USA., Ather JL; Department of Medicine, Larner College of Medicine, University of Vermont, Burlington, VT, USA., Janssen-Heininger YMW; Department of Pathology and Laboratory Medicine, Larner College of Medicine, University of Vermont, Burlington, USA., Poynter ME; Department of Medicine, Larner College of Medicine, University of Vermont, Burlington, VT, USA., Utermohlen O; Institute for Medical Microbiology, Immunology and Hygiene, University Hospital Cologne, Cologne, Germany., Krönke M; Institute for Medical Microbiology, Immunology and Hygiene, University Hospital Cologne, Cologne, Germany., van der Vliet A; Department of Pathology and Laboratory Medicine, Larner College of Medicine, University of Vermont, Burlington, USA. albert.van-der-vliet@uvm.edu.

Publikováno v: Mucosal immunology [Mucosal Immunol] 2022 May; Vol. 15 (5), pp. 977-989. Date of Electronic Publication: 2022 Jun 02.