Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Athena Sudom"'
Autor:
Marissa Mock, Alex W. Jacobitz, Christopher James Langmead, Athena Sudom, Daniel Yoo, Sara C. Humphreys, Mai Alday, Larysa Alekseychyk, Nicolas Angell, Vivian Bi, Hannah Catterall, Chen-Chun Chen, Hui-Ting Chou, Kip P. Conner, Kevin D. Cook, Ana R. Correia, Andrew Dykstra, Sudipa Ghimire-Rijal, Kevin Graham, Peter Grandsard, Joon Huh, John O. Hui, Mani Jain, Victoria Jann, Lei Jia, Sheree Johnstone, Neelam Khanal, Carl Kolvenbach, Linda Narhi, Rupa Padaki, Emma M. Pelegri-O’Day, Wei Qi, Vladimir Razinkov, Austin J. Rice, Richard Smith, Christopher Spahr, Jennitte Stevens, Yax Sun, Veena A. Thomas, Sarah van Driesche, Robert Vernon, Victoria Wagner, Kenneth W. Walker, Yangjie Wei, Dwight Winters, Melissa Yang, Iain D. G. Campuzano
Publikováno v:
mAbs, Vol 15, Iss 1 (2023)
ABSTRACTBiologic drug discovery pipelines are designed to deliver protein therapeutics that have exquisite functional potency and selectivity while also manifesting biophysical characteristics suitable for manufacturing, storage, and convenient admin
Externí odkaz:
https://doaj.org/article/c7e86c82a6684b888888da7d561e8891
Autor:
Bram Estes, Athena Sudom, Danyang Gong, Douglas A. Whittington, Vivian Li, Christopher Mohr, Danqing Li, Timothy P. Riley, Stone D.-H. Shi, Jun Zhang, Fernando Garces, Zhulun Wang
Publikováno v:
iScience, Vol 24, Iss 12, Pp 103447- (2021)
Summary: Bispecific antibodies (Bispecifics) demonstrate exceptional clinical potential to address some of the most complex diseases. However, Bispecific production in a single cell often requires the correct pairing of multiple polypeptide chains fo
Externí odkaz:
https://doaj.org/article/daec344ee874422b8d613ca7fb390ad7
Autor:
Mercedesz Balazs, Alexander Sternjak, Edwin Lamas, Ana Goyos, Petra Deegen, Benno Rattel, Joachim Wahl, Mozhgan Farshbaf, Angela Coxon, Xiaoshan Min, Tara Arvedson, Matthias Klinger, Oliver Thomas, Chi-Ming Li, Pamela Bogner, Matthias Friedrich, Rebecca Goldstein, Athena Sudom
Publikováno v:
Blood Adv
Multiple myeloma (MM) is a hematologic malignancy that is characterized by the accumulation of abnormal plasma cells (PCs) in the bone marrow (BM). Patient outcome may be improved with BiTE (bispecific T-cell engager) molecules, which redirect T cell
Autor:
Agnieszka Kielczewska, Igor D'Angelo, Maria Sheena Amador, Tina Wang, Athena Sudom, Xiaoshan Min, Palaniswami Rathanaswami, Craig Pigott, Ian N. Foltz
Publikováno v:
The Journal of biological chemistry. 298(2)
Therapeutic antibody development requires discovery of an antibody molecule with desired specificities and drug-like properties. For toxicological studies, a therapeutic antibody must bind the ortholog antigen with a similar affinity to the human tar
Autor:
Vivian S. W. Li, Fernando Garces, Danqing Li, Stone D.-H. Shi, Jun Zhang, Danyang Gong, Bram Estes, Douglas A. Whittington, Zhulun Wang, Athena Sudom, Christopher Mohr, Timothy P. Riley
Publikováno v:
iScience, Vol 24, Iss 12, Pp 103447-(2021)
iScience
iScience
Summary Bispecific antibodies (Bispecifics) demonstrate exceptional clinical potential to address some of the most complex diseases. However, Bispecific production in a single cell often requires the correct pairing of multiple polypeptide chains for
Autor:
Ai-Ching Lim, Jean Danao, Nikolai A. Sharkov, Steve Thibault, Songli Wang, Steve Wood, Edoardo Marcora, Santosh Talreja, Eric Bragg, Zhongqi Zhang, Jason Richardson, Ian Foltz, Rob Kegel, Hang Chen, Jodi Bradley, Xiaoshan Min, Shilpa Sambashivan, Zhulun Wang, Athena Sudom
Triggering receptor expressed on myeloid cells 2 (TREM2) is an immune receptor expressed on the surface of microglia, macrophages, dendritic cells, and osteoclasts. The R47H TREM2 variant is a significant risk factor for late-onset Alzheimer's diseas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aeef296643aab8b942f16b84784bc212
https://europepmc.org/articles/PMC6093241/
https://europepmc.org/articles/PMC6093241/
Autor:
Guoqing Chen, Kexue Li, Zhulun Wang, Lawrence R. McGee, Timothy D. Cushing, Paul Faulder, Ben Fisher, John Eksterowicz, Merrill Ayres, Mohmed K. Anwer, Fei Lee, Jinsong Liu, Bohdan Waszkowycz, Steven M. Rubenstein, Youngsook Shin, Ellyn Farrelly, Olga Plotnikova, Shou-Hua Xiao, Athena Sudom
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:1238-1244
The discovery, structure-based design, synthesis, and optimization of NIK inhibitors are described. Our work began with an HTS hit, imidazopyridinyl pyrimidinamine 1. We utilized homology modeling and conformational analysis to optimize the indole sc
Autor:
Zhaodan Cao, Merrill Ayres, Ping Cao, Xiong Gao, Zhulun Wang, Nigel Walker, Xiaoshan Min, Sheree Johnstone, Guoqing Chen, Fei Lee, Olga Plotnikova, Jinsong Liu, Athena Sudom
Publikováno v:
The Journal of Biological Chemistry
Background: NIK is a central component in the non-canonical NF-κB pathway, and its activity is associated with various diseases. Results: An N-terminal extension is required for activity and stabilizes the kinase in an active conformation. Conclusio
Autor:
Hua Tu, Lisa Julian, Nigel Walker, Maren Gulsrud Willcockson, Yosup Rew, Michael DeGraffenreid, Zhulun Wang, Juan C. Jaen, Daqing Sun, Ron C. Kelly, Athena Sudom, Seb Caille, Jacob Kaizerman, Jay P. Powers, Xuelei Yan, Qiuping Ye, Stefania Ursu, Ben Jiang, Felix Gonzalez-Lopez de Turiso, Randall W. Hungate, Dustin McMinn
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:405-410
The synthesis and SAR of a series of 4,4-disubstituted cyclohexylbenzamide inhibitors of 11β-HSD1 are described. Optimization rapidly led to potent, highly selective, and orally bioavailable inhibitors demonstrating efficacy in both rat and non-huma
Autor:
Jinsong Liu, Daqing Sun, Tracy Bostick, Randall W. Hungate, Dustin McMinn, Xiao He, Michael DeGraffenreid, Lisa Julian, Juan C. Jaen, Mario Monshouwer, Qiuping Ye, Athena Sudom, Rebekah Choi, Yongmei Di, Yosup Rew, Zhulun Wang, Stefania Ursu, Xuelei Yan, Hua Tu, Seb Caille, Nigel Walker, Jay P. Powers
Publikováno v:
Journal of Medicinal Chemistry. 51:3953-3960
We report the discovery of potent benzamide inhibitors of 11beta-hydroxysteroid dehydrogenase (11beta-HSD1). The optimization and correlation of in vitro and in vivo metabolic stability will be described. Through modifications to our initial lead 2,