Lowly methylated region analysis identifies EBF1 as a potential epigenetic modifier in breast cancer

Autor: Nora Fernandez-Jimenez, Athena Sklias, Szilvia Ecsedi, Vincent Cahais, Davide Degli-Esposti, Antonin Jay, Pierre Benoit Ancey, Hae Dong Woo, Hector Hernandez-Vargas, Zdenko Herceg

Publikováno v: Epigenetics, Vol 12, Iss 11, Pp 964-972 (2017)

Breast cancer (BC) encompasses heterogeneous pathologies with different subtypes exhibiting distinct molecular changes, including those related to DNA methylation. However, the role of these changes in mediating BC heterogeneity is poorly understood.

Externí odkaz: https://doaj.org/article/225c953a6a7f4e4396230b43bb6178db

Targeted deep sequencing of plasma circulating cell-free DNA reveals Vimentin and Fibulin 1 as potential epigenetic biomarkers for hepatocellular carcinoma.

Autor: Reetta Holmila, Athena Sklias, David C Muller, Davide Degli Esposti, Paule Guilloreau, James Mckay, Suleeporn Sangrajrang, Petcharin Srivatanakul, Pierre Hainaut, Philippe Merle, Zdenko Herceg, Andre Nogueira da Costa

Publikováno v: PLoS ONE, Vol 12, Iss 3, p e0174265 (2017)

Hepatocellular carcinoma (HCC) is the second most common cause of cancer death worldwide, but is still lacking sensitive and specific biomarkers for early diagnosis and prognosis. In this study, we applied targeted massively parallel semiconductor se

Externí odkaz: https://doaj.org/article/45a25572728a4beaa7ffc730890e46c4

List of contributors

Autor: Nobuyoshi Akimitsu, Marina Alexeeva, Juliana Almeida, Rodolfo Daniel Ávila-Avilés, Jérémy Berthelier, Akanksha Bhatnagar, Maria Boskovic, Nancy V.N. Carullo, J. Armando Casas-Mollano, Frances A. Champagne, Taiping Chen, Ravindresh Chhabra, James P. Curley, Gareth W. Davison, Gary L. Dunbar, Thomas Eggermann, Felice Elefant, Peter D. Fransquet, Hodaka Fujii, Toshitsugu Fujita, Leonardo Furci, Jose Garcia, Balaram Ghosh, Linn Gillberg, Karen Giménez-Orenga, Courtney W. Hanna, Zdenko Herceg, J. Manuel Hernández-Hernández, Line Hjort, Xiaotong Hu, Eveline M. Ibeagha-Awemu, Ali Jawaid, Wei Jiang, Oscar Juez, Ashley M. Karnay, Kentaro Kawata, Hasan Khatib, Eric W. Klee, Kerstin Klein, Eloïse A. Kremer, Ilkka Kronholm, Ho-Sun Lee, Frédérique Magdinier, Isabelle M. Mansuy, Rahia Mashoodh, Mihaly Mezei, Maria Miah, Matin Miryeganeh, Shiraz Mujtaba, Pamela N. Munster, Rabih Murr, Rūta Navakauskienė, Claudia Negrón-Lomas, Fereshteh S. Nugent, Elisa Oltra, Rena Onoguchi-Mizutani, Nail Can Öztürk, Romain Pacaud, Jacob Peedicayil, Prasad Pethe, Gerd P. Pfeifer, Sravani Pulya, Tibor A. Rauch, Marisol Resendiz, Marcus Roalsø, Jérôme D. Robin, Julien Rossignol, Joanne Ryan, Cíntia Barros Santos-Rebouças, Hidetoshi Saze, Ryan D. Shepard, Philippe Silar, Athena Sklias, Susan L. Slager, Kjetil Søreide, Bhairavi Srinageshwar, David M. Suter, Kenzui Taniue, Scott Thomas, Shulan Tian, Trygve O. Tollefsbol, Mark van der Giezen, Ludovica Vanzan, Günter Vogt, Darryl S. Watkins, Martin M. Watson, Loo Keat Wei, Jo Wrigglesworth, Toshimichi Yamada, Huihuang Yan, Jie Yang, Zhengzhou Ying, Ericka Zacarias, Feng C. Zhou

Publikováno v: Handbook of Epigenetics ISBN: 9780323919098

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3d4acac4d28fc4a91274d2bedcade435
https://doi.org/10.1016/b978-0-323-91909-8.00047-5

Epigenetic remodelling of enhancers in response to estrogen deprivation and re-stimulation

Autor: Athena Sklias, Claire Renard, Rita Khoueiry, Ludovica Vanzan, Aurélie Sallé, Cyrille Cuenin, Vincent Cahais, Nora Fernandez Jimenez, Liacine Bouaoun, Geoffroy Durand, Victor Ythier, Florence Le Calvez-Kelm, Zdenko Herceg, Andrea Halaburkova, Rabih Murr

Publikováno v: Addi. Archivo Digital para la Docencia y la Investigación
instname
Nucleic Acids Research

Estrogen hormones are implicated in a majority of breast cancers and estrogen receptor alpha (ER), the main nuclear factor mediating estrogen signaling, orchestrates a complex molecular circuitry that is not yet fully elucidated. Here, we investigate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b71dd12384537f94dfb73f53e43c131
http://hdl.handle.net/10810/53512

DNA methylome analysis identifies accelerated epigenetic aging associated with postmenopausal breast cancer susceptibility

Autor: Salvatore Panico, Ander Matheu Fernández, Françoise Clavel-Chapelon, Liacine Bouaoun, J. Ramón Quirós, Athena Sklias, Gianluca Severi, Elisabete Weiderpass, Myrto Barrdahl, Ruth C. Travis, Graham Byrnes, Paolo Vineis, Pagona Lagiou, Kim Overvad, Steve Horvath, Flavie Perrier, Antonia Trichopoulou, Rosario Tumino, Heiner Boeing, Therese Haugdahl Nøst, Laura Baglietto, Geoffroy Durand, Giovanna Masala, Pietro Ferrari, Elio Riboli, N. Charlotte Onland-Moret, Srikant Ambatipudi, Veronique Chajes, José María Huerta Castaño, Florence Le Calvez-Kelm, Cyrille Cuenin, Miguel Rodríguez-Barranco, Petra H.M. Peeters, Martijn E.T. Dollé, Androniki Naska, Claudia Agnoli, Torkjel M. Sandanger, Aurelio Barricarte, Silvia Polidoro, Antonio Agudo, Isabelle Romieu, Zdenko Herceg, Rudolf Kaaks, Hector Hernandez-Vargas, Marc J. Gunter, David C. Muller

Publikováno v: European Journal of Cancer, 75, 299. Elsevier Limited
Ambatipudi, S, Horvath, S, Perrier, F, Cuenin, C, Hernandez-Vargas, H, Le Calvez-Kelm, F, Durand, G, Byrnes, G, Ferrari, P, Bouaoun, L, Sklias, A, Chajes, V, Overvad, K, Severi, G, Baglietto, L, Clavel-Chapelon, F, Kaaks, R, Barrdahl, M, Boeing, H, Trichopoulou, A, Lagiou, P, Naska, A, Masala, G, Agnoli, C, Polidoro, S, Tumino, R, Panico, S, Dollé, M, Peeters, P H M, Onland-Moret, N C, Sandanger, T M, Nøst, T H, Weiderpass, E, Quiros, J R, Agudo, A, Rodríguez-Barranco, M, Huerta Castaño, J M, Barricarte, A, Fernández, A M, Travis, R C, Vineis, P, Muller, D C, Riboli, E, Gunter, M, Romieu, I & Herceg, Z 2017, ' DNA methylome analysis identifies accelerated epigenetic ageing associated with postmenopausal breast cancer susceptibility ', European journal of cancer (Oxford, England : 1990), vol. 75, pp. 299-307 . https://doi.org/10.1016/j.ejca.2017.01.014

Accepted manuscript version, licensed CC BY-NC-ND 4.0. Published version available in European Journal of Cancer, 75, 299-307. Aim of the study: A vast majority of human malignancies are associated with ageing, and age is a strong predictor of cancer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2a04efc1988899e2ee31d8ccbac0e0b
http://hdl.handle.net/10044/1/44191