Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Athena M. Klutz"'
Autor:
Xiyan Hou, Hyung Ryong Moon, Dilip K. Tosh, Seung Ah Choe, Zhan-Guo Gao, Hea Ok Kim, Wonjun Choi, Sang Kook Lee, Kenneth A. Jacobson, Lak Shin Jeong, Athena M. Klutz, Hyuk Woo Lee, Shantanu Pal
Publikováno v:
Journal of Medicinal Chemistry. 51:6609-6613
Novel D- and l-4'-thioadenosine derivatives lacking the 4'-hydroxymethyl moiety were synthesized, starting from d-mannose and d-gulonic gamma-lactone, respectively, as potent and selective species-independent A 3 adenosine receptor (AR) antagonists.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9844401051eb4192ec9d8f8253f6d47f
https://doi.org/10.1021/jm8008647
https://doi.org/10.1021/jm8008647
Publikováno v:
Bioconjugate Chemistry. 19:1660-1672
Surface modification of amine-terminated polyamidoamine (PAMAM) dendrimers by poly(ethylene glycol) (PEG) groups generally enhances water-solubility and biocompatibility for drug delivery applications. In order to provide guidelines for designing app
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fbc7cb9ff00f23680cdf78d01542171
https://doi.org/10.1021/bc700483s
https://doi.org/10.1021/bc700483s
Autor:
Kenneth A. Jacobson, Zhan-Guo Gao, Vincent L. Chen, Ben Wang, Athena M. Klutz, Andrei A. Ivanov
Publikováno v:
Journal of Medicinal Chemistry. 51:2088-2099
The binding modes at the A 2B adenosine receptor (AR) of 72 derivatives of adenosine and its 5'- N-methyluronamide with diverse substitutions at the 2 and N (6) positions were studied using a molecular modeling approach. The compounds in their recept
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a6a051b8a27d283a2ae98ada92b38e5
https://doi.org/10.1021/jm701442d
https://doi.org/10.1021/jm701442d
Publikováno v:
Biochemistry. 44:675-683
Base deamination is a major type of DNA damage under nitrosative stress. Endonuclease V initiates repair of deaminated base damage by making a nucleolytic incision one nucleotide away from the 3' side of the lesion. Within the endonuclease V family,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f75c79983807c9799e14d4e057568ae5
https://doi.org/10.1021/bi048752j
https://doi.org/10.1021/bi048752j
Autor:
Andrei A. Ivanov, Kenneth A. Jacobson, Zhan-Guo Gao, Athena M. Klutz, Moshe Chinn, Dilip K. Tosh
Publikováno v:
Journal of medicinal chemistry. 52(23)
(N)-Methanocarba nucleosides containing bicyclo[3.1.0]hexane replacement of the ribose ring previously demonstrated selectivity as A(3) adenosine receptor (AR) agonists (5'-uronamides) or antagonists (5'-truncated). Here, these two series were modifi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f1bc2947cbb6596af6f1a78549e9e84
https://pubmed.ncbi.nlm.nih.gov/19499950
https://pubmed.ncbi.nlm.nih.gov/19499950
Autor:
Pier Giovanni Baraldi, Kenneth A. Jacobson, Athena M. Klutz, Delia Preti, Dilip K. Tosh, Andrei A. Ivanov
Publikováno v:
Adenosine Receptors in Health and Disease ISBN: 9783540896142
A(3) adenosine receptor (A(3)AR) ligands have been modified to optimize their interaction with the A(3)AR. Most of these modifications have been made to the N(6) and C2 positions of adenine as well as the ribose moiety, and using a combination of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b99436972803d49e54412eb634d1af60
http://hdl.handle.net/11392/1378946
http://hdl.handle.net/11392/1378946
Publikováno v:
Journal of Nanobiotechnology, Vol 6, Iss 1, p 12 (2008)
Journal of Nanobiotechnology
Journal of Nanobiotechnology
Background An approach to use multivalent dendrimer carriers for delivery of nucleoside signaling molecules to their cell surface G protein-coupled receptors (GPCRs) was recently introduced. Results A known adenosine receptor (AR) agonist was conjuga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1c049e86b3008a4775704ea2892277d
https://doi.org/10.1186/1477-3155-6-12
https://doi.org/10.1186/1477-3155-6-12
G protein-coupled receptors, such as the adenosine A(2A) receptor, are dynamic proteins, which undergo agonist-dependent redistribution from the cell surface to intracellular membranous compartments, such as endosomes. In order to study the kinetics
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::494acec21dc7cc9946c58061234e2d3c
https://europepmc.org/articles/PMC2765816/
https://europepmc.org/articles/PMC2765816/
Publikováno v:
Bioconjug Chem
Activation of the A(2A) receptor, a G protein-coupled receptor (GPCR), by extracellular adenosine, is antiaggregatory in platelets and anti-inflammatory. Multiple copies of an A(2A) agonist, the nucleoside CGS21680, were coupled covalently to PAMAM d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccd3159b1a75b7177775b09dae9d4f9f
https://pubmed.ncbi.nlm.nih.gov/18176997
https://pubmed.ncbi.nlm.nih.gov/18176997
Autor:
Hyuk Woo Lee, Soo-Kyung Kim, Bhalchandra V. Joshi, Kenneth A. Jacobson, Hea Ok Kim, Zhan-Guo Gao, Lak Shin Jeong, Athena M. Klutz
Publikováno v:
Bioorganicmedicinal chemistry letters. 16(3)
The highly selective agonists of the A(3) adenosine receptor (AR), Cl-IB-MECA (2-chloro-N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine), and its 4'-thio analogue, were successfully converted into selective antagonists simply by appending a secon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5492abe68e1a974b39c1e48ef0f6f7ac
https://pubmed.ncbi.nlm.nih.gov/16289820
https://pubmed.ncbi.nlm.nih.gov/16289820