Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Athea Vichas"'
Autor:
Amanda K. Riley, Michael Grant, Aidan Snell, Elizabeth Cromwell, Athea Vichas, Sitapriya Moorthi, Callie Rominger, Shrikar P. Modukuri, Anatoly Urisman, Pau Castel, Lixin Wan, Alice H. Berger
Publikováno v:
iScience, Vol 27, Iss 8, Pp 110499- (2024)
Summary: RIT1 is a rare and understudied oncogene in lung cancer. Despite structural similarity to other RAS GTPase proteins such as KRAS, oncogenic RIT1 activity does not appear to be tightly regulated by nucleotide exchange or hydrolysis. Instead,
Externí odkaz:
https://doaj.org/article/80139380a31c425ebc93373b402148ab
Integrative oncogene-dependency mapping identifies RIT1 vulnerabilities and synergies in lung cancer
Autor:
Athea Vichas, Amanda K. Riley, Naomi T. Nkinsi, Shriya Kamlapurkar, Phoebe C. R. Parrish, April Lo, Fujiko Duke, Jennifer Chen, Iris Fung, Jacqueline Watson, Matthew Rees, Austin M. Gabel, James D. Thomas, Robert K. Bradley, John K. Lee, Emily M. Hatch, Marina K. Baine, Natasha Rekhtman, Marc Ladanyi, Federica Piccioni, Alice H. Berger
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
RIT1 mutations are mutually exclusive with other lung cancer drivers and lack targeted therapies. Here the authors examine genetic dependencies of mutant RIT1 with genome-wide CRISPR screens, revealing synergy between RIT1 and YAP1, and increased sen
Externí odkaz:
https://doaj.org/article/06e749d7f425413a87006cc1366f2c04
Publikováno v:
Molecular Cancer Research. 21:B028-B028
Since its discovery as an oncogene in 2014, mutations and amplifications in the small GTPase RIT1 (Ras-like in all tissues) have been associated with lung adenocarcinoma, myeloid malignancies, and uterine carcinosarcoma. Genome-sequencing studies in
Publikováno v:
Cancer Research. 83:2628-2628
Somatic mutations and focal amplifications in the small GTPase RIT1 (Ras-like in all tissues) account for over 13,500 lung cancer diagnoses annually, but treatment options are limited. Of the currently identified mutations, the M90I variant (RIT1M90I
Integrative oncogene-dependency mapping identifies RIT1 vulnerabilities and synergies in lung cancer
Autor:
Natasha Rekhtman, Athea Vichas, Robert K. Bradley, Jacqueline Watson, John K. Lee, Austin M. Gabel, Marina K. Baine, Amanda K. Riley, Shriya Kamlapurkar, Federica Piccioni, James D. Thomas, Iris Fung, Naomi T. Nkinsi, Emily M. Hatch, Jennifer Chen, Marc Ladanyi, Matthew G. Rees, Fujiko Duke, April Lo, Phoebe C. R. Parrish, Alice H. Berger
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Nature Communications
Nature Communications
CRISPR-based cancer dependency maps are accelerating advances in cancer precision medicine, but adequate functional maps are limited to the most common oncogenes. To identify opportunities for therapeutic intervention in other rarer subsets of cancer
Autor:
Amanda K. Riley, Athea Vichas, Naomi T. Nkinsi, Phoebe C. Parrish, Shriya Kamlapurkar, Alice H. Berger
Publikováno v:
Cancer Research. 82:2972-2972
Standard care of lung cancer treatment has shifted away from non-specific, cytotoxic chemotherapy in favor of targeted therapies based on genetic mutations within tumors. In 2014, somatic mutations in the small GTPase RIT1 (Ras-like in all tissues) w
Autor:
Alice H. Berger, Athea Vichas, Shriya Kamlapurkar, Amanda Riley, Naomi T. Nkinsi, Phoebe C. Parrish
Publikováno v:
Cancer Research. 81:2269-2269
Standard care of lung cancer is moving away from chemotherapy in favor of personalized approaches based on specific mutations in each tumor. Genome-sequencing studies have identified somatic mutations in the small GTPase RIT1 (Ras-like in all tissues
Publikováno v:
Cancer Research. 79:2726-2726
Treatment of lung cancer is evolving from standard cytotoxic to personalized treatment based on the molecular alterations unique to each patient’s tumor. In our recent work with TCGA and others, we identified somatic mutations in the gene encoding
Publikováno v:
The Journal of Cell Biology
The conserved Ski2-family helicase Obelus regulates alternative splicing of the Crumbs polarity protein to control epithelial polarity and junctional organization in Drosophila.
Alternative splicing can have profound consequences for protein act
Alternative splicing can have profound consequences for protein act
Autor:
Adam C. Paré, Athea Vichas, Christopher T. Fincher, Zachary Mirman, Dene L. Farrell, Avantika Mainieri, Jennifer A. Zallen
Publikováno v:
Nature. 527:398-398