A RAS-CaMKKβ-AMPKα2 pathway promotes senescence by licensing post-translational activation of C/EBPβ through a novel 3'UTR mechanism

Autor: Kevin P. Claffey, Peter F. Johnson, Mesfin Gonit, Myriam Gorospe, Atharva Bhat, Jacqueline Salotti, Jiji Chen, Sandip K. Basu, Benoit Viollet

Publikováno v: Oncogene
Oncogene, Nature Publishing Group, 2018, 37 (26), pp.3528-3548. ⟨10.1038/s41388-018-0190-7⟩
Oncogene, 2018, 37 (26), pp.3528-3548. ⟨10.1038/s41388-018-0190-7⟩

International audience; Oncogene-induced senescence (OIS) is an intrinsic tumor suppression mechanism that requires the p53 and RB pathways and post-translational activation of C/EBPβ through the RAS-ERK cascade. We previously reported that in trans

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89f96479720ffa7791b98f5a6d122dc7
https://pubmed.ncbi.nlm.nih.gov/29563610