Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Athanasios Glekas"'
Autor:
Blesida Punzalan, Athanasios Glekas, Nagavarakishore Pillarsetty, Peter Smith-Jones, Steven M. Larson, Nahida Khan
Publikováno v:
Journal of Nuclear Medicine. 52:1301-1307
Imatinib mesylate is a tyrosine kinase inhibitor that was approved by the U.S. Food and Drug Administration in 2001 for treatment of many different stages of chronic myeloid leukemia and in 2002 for treatment of gastrointestinal stromal tumors. Imati
Autor:
Steven M. Larson, Valerie A. Longo, Pat Zanzonico, Nagavarakishore Pillarsetty, Peter Smith-Jones, Blesida Punzalan, Mithat Gonen, Athanasios Glekas, Oula Penate Medina
Publikováno v:
Journal of Controlled Release. 149:292-298
Positron emission tomography (PET) of epidermal growth factor receptor (EGFR) kinase-specific radiolabeled tracers could provide a means for non-invasively characterizing EGFR expression and signaling activity in patients' tumors before, during, and
Autor:
Juri G. Gelovani, David Maxwell, Mikhail Doubrovin, Tatiana Beresten, Ashutosh Pal, Julius Balatoni, Steven M. Larson, Athanasios Glekas, William G. Bornmann, Ronald D. Finn, Mohammad Namavari, Lyudmila Ageyeva, Suren Soghomonyan, Aleksandr Shavrin
Publikováno v:
Molecular Imaging and Biology. 8:262-277
Positron emission tomography (PET) with epidermal growth factor receptor (EGFR) kinase-specific radiolabeled tracers could provide the means for noninvasive and repetitive imaging of heterogeneity of EGFR expression and signaling activity in tumors i
Autor:
Oliver Hobert, Zvi Fuks, E Randal Hofmann, Xinzhu Deng, Bayard D. Clarkson, Michael O. Hengartner, Luis Campodonico, Athanasios Glekas, Alberto Villanueva, Xianglei Yin, Paola Capodieci, Darren R. Veach, Carlos Cordon-Cardo, William Bornmann, Richard Kolesnick
Publikováno v:
Nature Genetics. 36:906-912
c-Abl, a conserved nonreceptor tyrosine kinase, integrates genotoxic stress responses, acting as a transducer of both pro- and antiapoptotic effector pathways. Nuclear c-Abl seems to interact with the p53 homolog p73 to elicit apoptosis. Although sev
Autor:
Susan Jeffry, Gregory W. Hewitt, Susan Erickson-Viitanen, Ronald M Klabe, Chien-An Chen, Beverly C Cordova, Scott McN. Sieburth, Sena Garber, Athanasios Glekas, George L. Trainor
Publikováno v:
Chemistry & Biology. 8:1161-1166
Background: Silicon is the element most similar to carbon, and bioactive organosilanes have therefore been of longstanding interest. Design of bioactive organosilanes has often involved a systematic replacement of a bioactive molecule's stable carbon
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 12:3625-3627
The first silanediol inhibitor of thermolysin is reported, prepared by analogy with the Grobelny/Bartlett phosphinate inhibitor. A Cbz group on nitrogen proved to be unstable to the triflic acid mediated silanediol deprotection and was replaced with
Autor:
Scott McN. Sieburth, Athanasios Glekas
Publikováno v:
ChemInform. 32
As a model system for the synthesis of complex silanediols, N,N-dimethyl 3-(tert-butyldiphenylsilyl)propionamide was prepared and treated with triflic acid, resulting in the removal of one phenyl group and yielding a silanol. Even with a large excess
Publikováno v:
Biochemistry. 44(15)
The hydrogen bonding interactions between the Klenow fragment of Escherichia coli DNA polymerase I with the proofreading exonuclease inactivated (KF(-)) and the minor groove of DNA were examined with modified oligodeoxynucleotides in which 3-deazagua
Autor:
F. Benedini, Khosrow Kashfi, Basil Rigas, Jianjun Gao, Simona Borgo, Jennie L. Williams, Piero Del Soldato, Jie Chen, Athanasios Glekas
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 312(3)
NO-donating aspirin (NO-ASA), a novel pharmacological agent currently undergoing clinical testing, consists of ASA to which a nitrate group is covalently linked via a spacer molecule. We synthesized the three positional isomers of NO-ASA with respect