Natural antioxidants that act against Alzheimer’s disease through modulation of the NRF2 pathway: a focus on their molecular mechanisms of action

Autor: Grammatiki Alexandra Sidiropoulou, Athanasios Metaxas, Malamati Kourti

Publikováno v: Frontiers in Endocrinology, Vol 14 (2023)

Characterized by a complex pathophysiology that includes the intraneuronal formation of neurofibrillary tangles and the extracellular deposition of β-amyloid plaques, Alzheimer’s disease (AD) is a terminal neurodegenerative disease that causes dem

Externí odkaz: https://doaj.org/article/ef8f6ce66ded425ca7fae0e5c3a57192

Neuroinflammation and amyloid-beta 40 are associated with reduced serotonin transporter (SERT) activity in a transgenic model of familial Alzheimer’s disease

Autor: Athanasios Metaxas, Marco Anzalone, Ramanan Vaitheeswaran, Sussanne Petersen, Anne M. Landau, Bente Finsen

Publikováno v: Alzheimer’s Research & Therapy, Vol 11, Iss 1, Pp 1-13 (2019)

Abstract Background Discrepant and often contradictory results have accumulated regarding the antidepressant and pro-cognitive effects of serotonin transporter (SERT) antagonists in Alzheimer’s disease. Methods To address the discrepancy, we measur

Externí odkaz: https://doaj.org/article/fef1eda0981c4208a000c2bbcbe4b95c

Serotonin augmentation therapy by escitalopram has minimal effects on amyloid-β levels in early-stage Alzheimer’s-like disease in mice

Autor: Christian Ulrich von Linstow, Jonas Waider, Manuela Grebing, Athanasios Metaxas, Klaus Peter Lesch, Bente Finsen

Publikováno v: Alzheimer’s Research & Therapy, Vol 9, Iss 1, Pp 1-12 (2017)

Abstract Background Dysfunction of the serotonergic (5-HTergic) system has been implicated in the cognitive and behavioural symptoms of Alzheimer’s disease (AD). Accumulation of toxic amyloid-β (Aβ) species is a hallmark of AD and an instigator o

Externí odkaz: https://doaj.org/article/6646f32c41c544b8812979343cb20ff4

Binding characterization of N‐(2‐chloro‐5‐thiomethylphenyl)‐N′‐(3‐[3H]3methoxy phenyl)‐N′‐methylguanidine ([3H]GMOM), a non‐competitive N‐methyl‐D‐aspartate (NMDA) receptor antagonist

Autor: Athanasios Metaxas, Bart N. M. van Berckel, Pieter J. Klein, Joost Verbeek, Emily C. Nash, Esther J. M. Kooijman, Véronique A. Renjaän, Sandeep S. V. Golla, Ronald Boellaard, Johannes A. M. Christiaans, Albert D. Windhorst, Josée E. Leysen

Publikováno v: Pharmacology Research & Perspectives, Vol 7, Iss 1, Pp n/a-n/a (2019)

Abstract Labeled with carbon‐11, N‐(2‐chloro‐5‐thiomethylphenyl)‐N′‐(3‐methoxyphenyl)‐N′‐methylguanidine ([11C]GMOM) is currently the only positron emission tomography (PET) tracer that has shown selectivity for the ion‐chan

Externí odkaz: https://doaj.org/article/d526cd10484549bca728a435a4c3653a

Mild Microglial Responses in the Cortex and Perivascular Macrophage Infiltration in Subcortical White Matter in Dogs with Age-Related Dementia Modelling Prodromal Alzheimer’s Disease

Autor: Athanasios Metaxas, Barbara Blicher Thomsen, Jørgen S. Agerholm, Bente Finsen, Mette Berendt, Sultan Darvesh, Camilla Thygesen, Trine Schütt, Katrine Tækker Krohn, Martin Wirenfeldt, Cecilie Madsen

Publikováno v: Thomsen, B B, Madsen, C, Krohn, K T, Thygesen, C, Schütt, T, Metaxas, A, Darvesh, S, Agerholm, J S, Wirenfeldt, M, Berendt, M & Finsen, B 2021, ' Mild Microglial Responses in the Cortex and Perivascular Macrophage Infiltration in Subcortical White Matter in Dogs with Age-Related Dementia Modelling Prodromal Alzheimer's Disease ', Journal of Alzheimer's Disease, vol. 82, no. 2, pp. 575-592 . https://doi.org/10.3233/JAD-210040
Journal of Alzheimer's Disease

Background: Microglia contribute to Alzheimer’s disease (AD) pathogenesis by clearing amyloid-β (Aβ) and driving neuroinflammation. Domestic dogs with age-related dementia (canine cognitive dysfunction (CCD)) develop cerebral amyloidosis like hum

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70dcc654c7f7a55e8f64e400b2073288
https://doi.org/10.3233/jad-210040