Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Athan Spiros"'
Autor:
Athan Spiros, Hugo Geerts
Publikováno v:
Frontiers in Neuroscience, Vol 15 (2021)
CNS disorders are lagging behind other indications in implementing genotype-dependent treatment algorithms for personalized medicine. This report uses a biophysically realistic computer model of an associative and dorsal motor cortico-striatal-thalam
Externí odkaz:
https://doaj.org/article/6dec646e7c1746408221f5ad361ef02f
Publikováno v:
Alzheimer’s Research & Therapy, Vol 10, Iss 1, Pp 1-14 (2018)
Abstract Background Despite a tremendous amount of information on the role of amyloid in Alzheimer’s disease (AD), almost all clinical trials testing this hypothesis have failed to generate clinically relevant cognitive effects. Methods We present
Externí odkaz:
https://doaj.org/article/1c93a673b0ca4110ae32cbdc8d84b827
Publikováno v:
Neuropsychiatric Disease and Treatment, Vol 2010, Iss Issue 1, Pp 589-603 (2010)
Athan Spiros1, Robert Carr1, Hugo Geerts1,21In Silico Biosciences, Berwyn, PA, USA; 2School of Medicine, University of Pennsylvania, PA, USAAbstract: Species differences in physiology and unique active human metabolites contribute to the limited pred
Externí odkaz:
https://doaj.org/article/dbfab43968d34192ba8f1f3adc8a528e
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e49732 (2012)
The tremendous advances in understanding the neurobiological circuits involved in schizophrenia have not translated into more effective treatments. An alternative strategy is to use a recently published 'Quantitative Systems Pharmacology' computer-ba
Externí odkaz:
https://doaj.org/article/d6a10b6d2079407a9454f13ab5070da1
Autor:
Hugo Geerts, Athan Spiros
Publikováno v:
Journal of Alzheimer's Disease. 78:413-424
Background: Many Alzheimer’s disease patients in clinical practice are on polypharmacy for treatment of comorbidities. Objective: While pharmacokinetic interactions between drugs have been relatively well established with corresponding treatment gu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30b5cfbe91ca1e41ea85d329b6dda77a
https://doi.org/10.3233/jad-200688
https://doi.org/10.3233/jad-200688
Autor:
Athan Spiros, Hugo Geerts
Publikováno v:
Alzheimer's & Dementia. 16
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cbfc1f7a9488054180099c5b23aea6b5
https://doi.org/10.1002/alz.038596
https://doi.org/10.1002/alz.038596
Autor:
Richard D. Hayes, Hugo Geerts, Ehtesham Iqbal, Athan Spiros, Giouliana Kadra, Hitesh Shetty, Robert Stewart
Publikováno v:
Journal of Psychopharmacology (Oxford, England)
Background: Computer-modelling approaches have the potential to predict the interactions between different antipsychotics and provide guidance for polypharmacy. Aims: To evaluate the accuracy of the quantitative systems pharmacology platform to predi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26a321640bdbb22499d5d21a08854cc0
http://europepmc.org/articles/PMC6238161
http://europepmc.org/articles/PMC6238161
Publikováno v:
Schizophrenia Research. 197:261-268
Long-acting injectable (LAI) antipsychotic formulations are increasingly used for improving patient compliance and long-term outcomes. Transitioning to LAIs raises questions regarding how optimum efficacy can be rapidly achieved while minimizing pote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c6f7f95c6aba966b7e1061237e52844
https://doi.org/10.1016/j.schres.2017.11.016
https://doi.org/10.1016/j.schres.2017.11.016
Publikováno v:
European Neuropsychopharmacology. 27:107-119
Despite new insights into the pathophysiology of schizophrenia and clinical trials with highly selective drugs, no new therapeutic breakthroughs have been identified. We present a semi-mechanistic Quantitative Systems Pharmacology (QSP) computer mode
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6b1b869e3d728c2c701a01360d6be84
https://doi.org/10.1016/j.euroneuro.2016.12.006
https://doi.org/10.1016/j.euroneuro.2016.12.006
Publikováno v:
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. 50
BOLD fMRI is increasingly used mostly in an observational way to probe the effect of genotypes or therapeutic intervention in normal and diseased subjects. We use a mechanism-based quantitative systems pharmacology computer model of a human cortical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4696d436668ecc2e74039eb12c6da82
https://pubmed.ncbi.nlm.nih.gov/33951587
https://pubmed.ncbi.nlm.nih.gov/33951587