Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Atf3, activating transcription factor 3"'
Autor:
Kenneth K.W. To, Jiang Ma, Stella Chai, Chunyuan Zhang, Chun Yin, Sheng Yao, Xu Wu, Thomas Efferth, Yang Ye, Onat Kadioglu, Ge Lin
Publikováno v:
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 7, Pp 1885-1902 (2021)
Acta Pharmaceutica Sinica B, Vol 11, Iss 7, Pp 1885-1902 (2021)
Multidrug resistance (MDR) mediated by ATP binding cassette subfamily B member 1 (ABCB1) is significantly hindering effective cancer chemotherapy. However, currently, no ABCB1-inhibitory drugs have been approved to treat MDR cancer clinically, mainly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b10ca45cdbb87dcf2ef29e5865d5f864
https://doi.org/10.1016/j.apsb.2020.12.021
https://doi.org/10.1016/j.apsb.2020.12.021
Publikováno v:
Pharmacological Research
Graphical abstract Molecular targets modulated by artemisinins in respiratory diseases.
Artemisinins are sesquiterpene lactones with a peroxide moiety that are isolated from the herb Artemisia annua. It has been used for centuries for the treatm
Artemisinins are sesquiterpene lactones with a peroxide moiety that are isolated from the herb Artemisia annua. It has been used for centuries for the treatm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::184b9b3d7b7767e97cb84ac3227c7da4
Publikováno v:
The Journal of Biological Chemistry
Precise gene insertion or replacement in cells and animals that requires incorporation of a foreign DNA template into the genome target site by homology-directed repair (HDR) remains an inefficient process. One of the limiting factors for the ineffic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73a8fe044fd2ac76e19bfb1d1476e8c1
https://doi.org/10.1016/j.jbc.2021.100525
https://doi.org/10.1016/j.jbc.2021.100525
Publikováno v:
Biochemical Journal
ERK1/2 (extracellular-signal-regulated kinase 1/2) and their substrates RSKs (p90 ribosomal S6 kinases) phosphorylate different transcription factors, contributing differentially to transcriptomic profiles. In cardiomyocytes ERK1/2 are required for >
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb9ea954d433660d58ba0f0f41fde7cd
http://europepmc.org/articles/PMC3573779
http://europepmc.org/articles/PMC3573779
Autor:
Christoforos, Tsantoulas, Lan, Zhu, Ping, Yip, John, Grist, Gregory J, Michael, Stephen B, McMahon
Publikováno v:
Experimental Neurology
Peripheral nerve injuries caused by trauma are associated with increased sensory neuron excitability and debilitating chronic pain symptoms. Axotomy-induced alterations in the function of ion channels are thought to largely underlie the pathophysiolo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::f6abc339e85aa3a359d061c6cf3562ed
https://doi.org/10.1016/j.expneurol.2013.11.011
https://doi.org/10.1016/j.expneurol.2013.11.011
Autor:
Jörg Linde, Wolfgang Schmidt-Heck, Sebastian Zellmer, Madlen Matz-Soja, Reinhard Guthke, Anke Meyer-Baese, Sebastian Vlaic, Rolf Gebhardt, E Marbach
Publikováno v:
BMC Systems Biology, Vol 6, Iss 1, p 147 (2012)
BMC Systems Biology
BMC Systems Biology
Background Network inference is an important tool to reveal the underlying interactions of biological systems. In the liver, a complex system of transcription factors is active to distribute signals and induce the cellular response following extracel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::116a31eb1b5c6f512481bbdaf511aaf8
https://doi.org/10.1186/1752-0509-6-147
https://doi.org/10.1186/1752-0509-6-147
Akademický článek
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Akademický článek
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Publikováno v:
FEBS Open Bio
FEBS Open Bio, Vol 5, Iss 1, Pp 733-740 (2015)
FEBS Open Bio, Vol 5, Iss 1, Pp 733-740 (2015)
Highlights • MeCP2 is upregulated in the dorsal root ganglia (DRG) from a spared nerve injury model of neuropathic pain. • miR-19a- and miR-301-mediated regulation of MeCP2 resulted in Bdnf alteration. • MeCP2 T158A mice have decreased mechanic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8c3396cdfe19e52dfe38ccaccbe96a6
Autor:
Alexei Verkhratsky, Randy Van der Ploeg, Paul Fernyhough, Jason Schapansky, Elena Zherebitskaya, Darrell R. Smith, Natasha Solovyova, Eli Akude
Publikováno v:
Scopus-Elsevier
ASN NEURO
ASN NEURO
Distal symmetrical sensory neuropathy in diabetes involves the dying back of axons, and the pathology equates with axonal dystrophy generated under conditions of aberrant Ca2+ signalling. Previous work has described abnormalities in Ca2+ homoeostasis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ef9c341404d604b91006d48fe10ffd1
http://www.scopus.com/inward/record.url?eid=2-s2.0-84864003480&partnerID=MN8TOARS
http://www.scopus.com/inward/record.url?eid=2-s2.0-84864003480&partnerID=MN8TOARS