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Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1843:2807-2815
Leukocyte Elastase Inhibitor (LEI, also called serpin B1) is a protein involved in apoptosis among other physiological processes. We have previously shown that upon cleavage by its cognate protease, LEI is transformed into L-DNase II, a protein with
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. (10):1755-1766
LEI (Leukocyte Elastase Inhibitor), the precursor of the pro-apoptotic molecule L-DNase II, belongs to the ovalbumin subgroup of serpins. Several serpins can inhibit apoptosis: the viral serpin Crm A inhibits Fas or TNFα-induced apoptosis, and overe