Výsledky vyhledávání - "Atena Yasari"

Activating mutations in FGFR3 are associated with clonal expansion events and high de novo rates in the male germline

Autor: Sofia Moura, Ingrid Hartl, Atena Yasari, Veronika Brumovska, Yasmin Striedner, Marina Bishara, Theresa Mair, Thomas Ebner, Gerhard J. Schütz, Eva Sevcsik, Irene Tiemann-Boege

Delayed fatherhood results in a higher risk to inherit a new germline mutation that might result in a congenital disorder in the offspring. In particular, some FGFR3 mutations increase in frequency with age, but there are still a large number of unch

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::875cf5f30ab43faf85a7764db57f7022
https://doi.org/10.1101/2022.07.31.502216

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Measurement of FGFR3 signaling at the cell membrane via total internal reflection fluorescence microscopy to compare the activation of FGFR3 mutants

Autor: Ingrid Hartl, Veronika Brumovska, Yasmin Striedner, Atena Yasari, Gerhard J. Schütz, Eva Sevcsik, Irene Tiemann-Boege

Publikováno v: The Journal of biological chemistry.

Fibroblast growth factor receptors (FGFRs) initiate signal transduction via the RAS/MAPK pathway by their tyrosine-kinase activation known to determine cell-growth, tissue differentiation, and apoptosis. Recently, many missense mutations have been re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce2e0e81a70aad84c2e079b302364b79
https://pubmed.ncbi.nlm.nih.gov/36581204

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Pathogenic postzygotic mosaicism in the tyrosine receptor kinase pathway: potential unidentified human disease hidden away in a few cells

Autor: Irene Tiemann-Boege, Atena Yasari, Michal Zurovec, Theresa Mair

Publikováno v: The Febs Journal

Gain‐of‐function mutations in the receptor tyrosine kinase pathway are often lethal; yet, it might be tolerated at very low frequencies as postzygotic mosaics resulting in a vast range of new phenotypes, unknown before the detection of the mosaic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6dc74ef1f66c45d347fcd931757572fe
https://doi.org/10.1111/febs.15528

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Quantitation of Fgfr3 Signaling Via Grb2 Recruitment on Micropatterned Surfaces

Autor: Ingrid Hartl, Veronika Brumovska, Yasmin Striedner, Atena Yasari, Gerhard J. Schütz, Eva Sevcsik, Irene Tiemann-Boege

Publikováno v: SSRN Electronic Journal.

Fibroblast growth factor receptors (FGFRs) initiate signal transduction via the RAS/MAPK pathway by their tyrosine-kinase activation known to determine cell-growth, tissue differentiation and apoptosis. Recently, many missense mutations have been rep

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6128cd5e685be1cc6c701c87dd40ea8d
https://doi.org/10.2139/ssrn.4080536

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A novel microRNA located in the TrkC gene regulates the Wnt signaling pathway and is differentially expressed in colorectal cancer specimens

Autor: Atena Yasari, Hadi Najafi, Maryam Nikkhah, Seyed Javad Mowla, Meisam Jafarzadeh, Sadat Dokanehiifard, Bahram M. Soltani

Publikováno v: Journal of Biological Chemistry. 292:7566-7577

Tropomyosin receptor kinase C (TrkC) is involved in cell survival, apoptosis, differentiation, and tumorigenesis. TrkC diverse functions might be attributed to the hypothetical non-coding RNAs embedded within the gene. Using bioinformatics approaches

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e076abc14c47b0566f11cafae5081ccf
https://doi.org/10.1074/jbc.m116.760710

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