Inference for Stochastic Chemical Kinetics Using Moment Equations and System Size Expansion.

Autor: Fabian Fröhlich, Philipp Thomas, Atefeh Kazeroonian, Fabian J Theis, Ramon Grima, Jan Hasenauer

Publikováno v: PLoS Computational Biology, Vol 12, Iss 7, p e1005030 (2016)

Quantitative mechanistic models are valuable tools for disentangling biochemical pathways and for achieving a comprehensive understanding of biological systems. However, to be quantitative the parameters of these models have to be estimated from expe

Externí odkaz: https://doaj.org/article/988b8f51da014a9ab685bc6bd0fa90ef

Early emergence of T central memory precursors programs clonal dominance during chronic viral infection

Autor: Roza Rahimi, Lorenz Kretschmer, Adrien Jolly, Simon Grassmann, Matthias Schiemann, Michael Flossdorf, M. Zeeshan Chaudhry, Qin Zhang, Justin Leube, Ludwig O. Pachmayr, Dirk H. Busch, Lorenz Mihatsch, Jonas Mir, Luka Cicin-Sain, Atefeh Kazeroonian, Inge Hensel, Sophie Flommersfeld, Kilian Schober, Veit R. Buchholz, Thomas Höfer

Publikováno v: Nature Immunology. 21:1563-1573

Chronic cytomegalovirus (CMV) infection leads to long-term maintenance of extraordinarily large CMV-specific T cell populations. The magnitude of this so-called ‘memory inflation’ is thought to mainly depend on antigenic stimulation during the ch

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::907c74110e3cccaec4837f14b717e56e
https://doi.org/10.1038/s41590-020-00807-y

Early emergence of T central memory precursors programs clonal dominance during chronic viral infection

Autor: Simon, Grassmann, Lorenz, Mihatsch, Jonas, Mir, Atefeh, Kazeroonian, Roza, Rahimi, Sophie, Flommersfeld, Kilian, Schober, Inge, Hensel, Justin, Leube, Ludwig O, Pachmayr, Lorenz, Kretschmer, Qin, Zhang, Adrien, Jolly, M Zeeshan, Chaudhry, Matthias, Schiemann, Luka, Cicin-Sain, Thomas, Höfer, Dirk H, Busch, Michael, Flossdorf, Veit R, Buchholz

Publikováno v: Nature immunology. 21(12)

Chronic cytomegalovirus (CMV) infection leads to long-term maintenance of extraordinarily large CMV-specific T cell populations. The magnitude of this so-called 'memory inflation' is thought to mainly depend on antigenic stimulation during the chroni

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b833283aac84fe05cae5b34a2aa7431b
https://pubmed.ncbi.nlm.nih.gov/33122851

Inference for Stochastic Chemical Kinetics Using Moment Equations and System Size Expansion

Autor: Jan Hasenauer, Fabian J. Theis, Atefeh Kazeroonian, Fabian Fröhlich, Ramon Grima, Philipp Thomas

Publikováno v: PLoS Computational Biology
PLoS Comput. Biol. 12:e1005030 (2016)
Grima, R 2016, ' Inference for stochastic chemical kinetics using moment equations and system size expansion ', PLoS Computational Biology . https://doi.org/10.1371/journal.pcbi.1005030
PLoS Computational Biology, Vol 12, Iss 7, p e1005030 (2016)

Quantitative mechanistic models are valuable tools for disentangling biochemical pathways and for achieving a comprehensive understanding of biological systems. However, to be quantitative the parameters of these models have to be estimated from expe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a868527dcab558be622c60aeec352b2
http://europepmc.org/articles/PMC4957800

Modeling of stochastic biological processes with non-polynomial propensities using non-central conditional moment equation

Autor: Jan Hasenauer, Atefeh Kazeroonian, Fabian J. Theis

Publikováno v: Scopus-Elsevier

Biological processes exhibiting stochastic fluctuations are mainly modeled using the Chemical Master Equation (CME). As a direct simulation of the CME is often computationally intractable, we recently introduced the Method of Conditional Moments (MCM

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ffd4597ab5440d6a22207601e1c30a8
http://www.scopus.com/inward/record.url?eid=2-s2.0-84929714133&partnerID=MN8TOARS