Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Atef Zaher"'
Autor:
Melissa Wasserstein, Robin Lachmann, Carla Hollak, Laila Arash-Kaps, Antonio Barbato, Renata C. Gallagher, Roberto Giugliani, Norberto Bernardo Guelbert, Takayuki Ikezoe, Olivier Lidove, Paulina Mabe, Eugen Mengel, Maurizio Scarpa, Eubekir Senates, Michel Tchan, Jesus Villarrubia, Yixin Chen, Sandy Furey, Beth L. Thurberg, Atef Zaher, Monica Kumar
Publikováno v:
Genetics in medicine, 24(7), 1425-1436. Lippincott Williams and Wilkins
Purpose: This trial aimed to assess the efficacy and safety of olipudase alfa enzyme replacement therapy for non–central nervous system manifestations of acid sphingomyelinase deficiency (ASMD) in adults. Methods: A phase 2/3, 52 week, internationa
Autor:
Paraskevi Giannakakou, David M. Nanus, Mario A. Eisenberger, Fred Saad, Brian J. Kirby, Luigi Portella, Yang Bai, Shinsuke Tasaki, Katsuhiro Kita, Karla V. Ballman, Ted P. Szatrowski, Atef Zaher, John Stewart, Daniel Worroll, Seaho Kim, Giuseppe Galletti, Ada Gjyrezi, Emmanuel S. Antonarakis, Scott T. Tagawa
Copy number for AR-V7 and ARv567es stratified by PSA response AR, androgen receptor; IQ, interquartile; PSA50, 50% reduction from baseline in prostate-specific antigen; SD, standard deviation.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::597a0cf3213e6dcfd83ef601908bf0cc
https://doi.org/10.1158/1078-0432.22472490.v1
https://doi.org/10.1158/1078-0432.22472490.v1
Autor:
Paraskevi Giannakakou, David M. Nanus, Mario A. Eisenberger, Fred Saad, Brian J. Kirby, Luigi Portella, Yang Bai, Shinsuke Tasaki, Katsuhiro Kita, Karla V. Ballman, Ted P. Szatrowski, Atef Zaher, John Stewart, Daniel Worroll, Seaho Kim, Giuseppe Galletti, Ada Gjyrezi, Emmanuel S. Antonarakis, Scott T. Tagawa
Assay sensitivity in 22RV1 prostate cancer cells spiked-in healthy donor blood run through the GEDI device. AR-FL (blue) and AR-V7 (red) mRNA expression (#copies per sample) was determined by ddPCR in varying amounts of 22RV1 cells in the presence of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a874990aad857a46f4e29111cf2be7a
https://doi.org/10.1158/1078-0432.22472511.v1
https://doi.org/10.1158/1078-0432.22472511.v1
Autor:
Paraskevi Giannakakou, David M. Nanus, Mario A. Eisenberger, Fred Saad, Brian J. Kirby, Luigi Portella, Yang Bai, Shinsuke Tasaki, Katsuhiro Kita, Karla V. Ballman, Ted P. Szatrowski, Atef Zaher, John Stewart, Daniel Worroll, Seaho Kim, Giuseppe Galletti, Ada Gjyrezi, Emmanuel S. Antonarakis, Scott T. Tagawa
Copy number for AR-FL, AR-V7 and ARv567es for the evaluable population at baseline AR, androgen receptor; FL, full length.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00523b189b9e02fc874ce9d6df5cad39
https://doi.org/10.1158/1078-0432.22472493
https://doi.org/10.1158/1078-0432.22472493
Autor:
Paraskevi Giannakakou, David M. Nanus, Mario A. Eisenberger, Fred Saad, Brian J. Kirby, Luigi Portella, Yang Bai, Shinsuke Tasaki, Katsuhiro Kita, Karla V. Ballman, Ted P. Szatrowski, Atef Zaher, John Stewart, Daniel Worroll, Seaho Kim, Giuseppe Galletti, Ada Gjyrezi, Emmanuel S. Antonarakis, Scott T. Tagawa
ddPCR primer and probe sequences AR, androgen receptor; FL, full length.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a98075ac90c4f178a080d9522ebc204
https://doi.org/10.1158/1078-0432.22472496.v1
https://doi.org/10.1158/1078-0432.22472496.v1
Autor:
Paraskevi Giannakakou, David M. Nanus, Mario A. Eisenberger, Fred Saad, Brian J. Kirby, Luigi Portella, Yang Bai, Shinsuke Tasaki, Katsuhiro Kita, Karla V. Ballman, Ted P. Szatrowski, Atef Zaher, John Stewart, Daniel Worroll, Seaho Kim, Giuseppe Galletti, Ada Gjyrezi, Emmanuel S. Antonarakis, Scott T. Tagawa
Visual representation of AR-FL and AR splice variant expression per patient at baseline Data are shown as positive (green for AR-FL; red for AR-V7; blue for ARv567es) or negative (white boxes) for each transcript. AR, androgen receptor; FL, full leng
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0aa3ca187149da219d88411a6fe007ee
https://doi.org/10.1158/1078-0432.22472505.v1
https://doi.org/10.1158/1078-0432.22472505.v1
Autor:
Paraskevi Giannakakou, David M. Nanus, Mario A. Eisenberger, Fred Saad, Brian J. Kirby, Luigi Portella, Yang Bai, Shinsuke Tasaki, Katsuhiro Kita, Karla V. Ballman, Ted P. Szatrowski, Atef Zaher, John Stewart, Daniel Worroll, Seaho Kim, Giuseppe Galletti, Ada Gjyrezi, Emmanuel S. Antonarakis, Scott T. Tagawa
AR-FL and AR-V expression in healthy donor blood run through the GEDI device. The mRNA expression levels of AR-FL (blue), AR-v7 (red) and AR-v567es (green) were analyzed in healthy donor blood from 10 volunteers. As previously described, 1 mL of heal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cf2d281efb7e7c3571f6e099a55c856
https://doi.org/10.1158/1078-0432.22472508.v1
https://doi.org/10.1158/1078-0432.22472508.v1
Autor:
Patrick B. Deegan, Ozlem Goker-Alpan, Tarekegn Geberhiwot, Robert J. Hopkin, Elena Lukina, Anna Tylki-Szymanska, Atef Zaher, Charlotte Sensinger, Sebastiaan J.M. Gaemers, Vijay Modur, Beth L. Thurberg, Jyoti Sharma, Behzad Najafian, Michael Mauer, Pronabesh DasMahapatra, William R. Wilcox, Dominique P. Germain
Publikováno v:
Molecular Genetics and Metabolism. 138:106963
Venglustat inhibits the enzymatic conversion of ceramide to glucosylceramide, reducing available substrate for the synthesis of more complex glycosphingolipids. It offers a potential new approach to the treatment of patients with Fabry disease (α-Ga
Autor:
Priya S. Kishnani, David Kronn, Anaïs Brassier, Alexander Broomfield, James Davison, Si Houn Hahn, Satoko Kumada, François Labarthe, Hirotaka Ohki, Samia Pichard, S. Grace Prakalapakorn, Kristina An Haack, Barbara Kittner, Xianzhang Meng, Susan Sparks, Catherine Wilson, Atef Zaher, Yin-Hsiu Chien
Publikováno v:
Genetics in Medicine. 25:100328
Mini-COMET (NCT03019406; Sanofi) is a phase 2, open-label, ascending-dose, 3-cohort study, evaluating avalglucosidase alfa safety, pharmacokinetics, and efficacy in individuals with infantile-onset Pompe disease aged18 years who previously received a
Autor:
Chanchala Kaddi, Mengdi Tao, Silke Bergeler, Randolph Leiser, Mike Walker, Hugo Geerts, Kelly George, Catherine Wilson, Catherine Ortemann-Renon, Atef Zaher, Susana Zaph
Publikováno v:
Molecular Genetics and Metabolism. 138:107174