Updated protocol of the SANO trial: a stepped-wedge cluster randomised trial comparing surgery with active surveillance after neoadjuvant chemoradiotherapy for oesophageal cancer

Autor: Ben M. Eyck, Berend J. van der Wilk, Bo Jan Noordman, Bas P. L. Wijnhoven, Sjoerd M. Lagarde, Henk H. Hartgrink, Peter Paul L. O. Coene, Jan Willem T. Dekker, Michail Doukas, Ate van der Gaast, Joos Heisterkamp, Ewout A. Kouwenhoven, Grard A. P. Nieuwenhuijzen, Jean-Pierre E. N. Pierie, Camiel Rosman, Johanna W. van Sandick, Maurice J. C. van der Sangen, Meindert N. Sosef, Edwin S. van der Zaag, Manon C. W. Spaander, Roelf Valkema, Hester F. Lingsma, Ewout W. Steyerberg, J. Jan B. van Lanschot, on behalf of the SANO-study group

Publikováno v: Trials, Vol 22, Iss 1, Pp 1-6 (2021)

Abstract Background The Surgery As Needed for Oesophageal cancer (SANO) trial compares active surveillance with standard oesophagectomy for patients with a clinically complete response (cCR) to neoadjuvant chemoradiotherapy. The last patient with a c

Externí odkaz: https://doaj.org/article/03db1ac699e94e918426800e18e2f668

Neoadjuvant chemoradiotherapy plus surgery versus active surveillance for oesophageal cancer: a stepped-wedge cluster randomised trial

Autor: Bo Jan Noordman, Bas P. L. Wijnhoven, Sjoerd M. Lagarde, Jurjen J. Boonstra, Peter Paul L. O. Coene, Jan Willem T. Dekker, Michael Doukas, Ate van der Gaast, Joos Heisterkamp, Ewout A. Kouwenhoven, Grard A. P. Nieuwenhuijzen, Jean-Pierre E. N. Pierie, Camiel Rosman, Johanna W. van Sandick, Maurice J. C. van der Sangen, Meindert N. Sosef, Manon C. W. Spaander, Roelf Valkema, Edwin S. van der Zaag, Ewout W. Steyerberg, J. Jan B. van Lanschot, on behalf of the SANO-study group

Publikováno v: BMC Cancer, Vol 18, Iss 1, Pp 1-12 (2018)

Abstract Background Neoadjuvant chemoradiotherapy (nCRT) plus surgery is a standard treatment for locally advanced oesophageal cancer. With this treatment, 29% of patients have a pathologically complete response in the resection specimen. This provid

Externí odkaz: https://doaj.org/article/0805a4431d264f0ebffc6b2b562c7138

Effect of the Proton Pump Inhibitor Esomeprazole on the Systemic Exposure of Capecitabine

Autor: Peter de Bruijn, Sander Bins, Ferry A.L.M. Eskens, Femke M. de Man, Ron H.J. Mathijssen, Niels Heersche, Esther Oomen-de Hoop, Leni van Doorn, Ivo Bijl, Ate van der Gaast

Publikováno v: Clinical Pharmacology and Therapeutics, 111(2), 455-460. Wiley-Blackwell

Retrospective data suggest that gastric acid reduction by proton pump inhibitors (PPIs) impairs the dissolution and subsequent absorption of capecitabine, and thus potentially reduces the capecitabine exposure. Therefore, we examined prospectively th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::814759c4ce80aa423634215ecc3cfb08
https://doi.org/10.1002/cpt.2444

Active Surveillance Versus Immediate Surgery in Clinically Complete Responders after Neoadjuvant Chemoradiotherapy for Esophageal Cancer: A Multicenter Propensity Matched Study

Autor: Suzanne S. Gisbertz, Bas P. L. Wijnhoven, Daan Nieboer, Liekele E. Oostenbrug, Suzan Nikkessen, Erik J. Schoon, Katharina Biermann, Lisanne K A Neijenhuis, Meindert N. Sosef, Robert G. Riedl, J. Jan B. van Lanschot, Roelf Valkema, Bo Jan Noordman, Manon C.W. Spaander, Misha D. P. Luyer, Roel J. Bennink, Michael Doukas, Mark I. van Berge Henegouwen, Mark J. Roef, Sybren L. Meijer, Kausilia K. Krishnadath, Grard A. P. Nieuwenhuijzen, Ate van der Gaast, Ineke van Lijnschoten, Berend J van der Wilk, Sjoerd M. Lagarde

Publikováno v: Annals of Surgery, 274(6), 1009-1016. Lippincott Williams and Wilkins
Annals of surgery, 274(6), 1009-1016. Lippincott Williams and Wilkins
van der Wilk, B J, Noordman, B J, Neijenhuis, L K A, Nieboer, D, Nieuwenhuijzen, G A P, Sosef, M N, Henegouwen, M I V B, Lagarde, S M, Spaander, M C W, Valkema, R, Biermann, K, Wijnhoven, B P L, van der Gaast, A, van Lanschot, J J B, Doukas, M, Nikkessen, S, Luyer, M, Schoon, E J, Roef, M J, van Lijnschoten, I, Oostenbrug, L E, Riedl, R G, Gisbertz, S S, Krishnadath, K K, Bennink, R J & Meijer, S L 2021, ' Active Surveillance Versus Immediate Surgery in Clinically Complete Responders after Neoadjuvant Chemoradiotherapy for Esophageal Cancer : A Multicenter Propensity Matched Study ', Annals of Surgery, vol. 274, no. 6, pp. 1009-1016 . https://doi.org/10.1097/SLA.0000000000003636
Annals of Surgery, 274(6), 1009-1016. Lippincott Williams & Wilkins

Objective:This study compared outcomes of patients with esophageal cancer and clinically complete response (cCR) after neoadjuvant chemoradiotherapy (nCRT) undergoing active surveillance or immediate surgery. Background:Since nearly one-third of pati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ca880c8f5b9d5fb6232f977d2e68900
https://research.vumc.nl/en/publications/3fd0c95b-e5e6-43cf-8306-94101747eab9

681 PATTERN OF RECURRENCE IN PATIENTS WITH A PATHOLOGICALLY COMPLETE RESPONSE AFTER NEOADJUVANT CHEMORADIOTHERAPY AND SURGERY FOR OESOPHAGEAL CANCER

Autor: Leonie R Werf, Marloes Jongh, Sjoerd M. Lagarde, Eelke L A Toxopeus, Ate van der Gaast, Bas P. L. Wijnhoven, J Jan B Lanschot, Ben M Eyck, Joost J. Nuyttens

Publikováno v: Diseases of the Esophagus. 34

Neoadjuvant chemoradiotherapy (nCRT) and surgery is a widely used treatment for locally advanced resectable oesophageal cancer, with 20 and 50% of patients having a pathological complete response (pCR). Disease, however, still recurs in 20–30% of t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e3c0fc579946f47e72b23e6bc568342e
https://doi.org/10.1093/dote/doab052.681