Výsledky vyhledávání - "Atanu Ghoshal"

1-Methyl-1H-pyrazole-5-carboxamide Derivatives Exhibit Unexpected Acute Mammalian Toxicity

Autor: Nghi H. Nguyen, Abdul Jabbar, Fei Huang, Sean L. McGee, Yaqing Jiao, Abhijit Kundu, Michael J. Palmer, Banfeng Ruan, Bill C.H. Chang, Thuy G. Le, Jonathan B. Baell, Liam G. Hall, Atanu Ghoshal, Lian Xue, Jose F. Garcia-Bustos, Robin B. Gasser, Timothy N. C. Wells, Sarah Preston, Sheree D. Martin

Publikováno v: Journal of Medicinal Chemistry. 64:840-844

A series of 1-methyl-1H-pyrazole-5-carboxamides were synthesized as potent inhibitors of the parasitic nematode of sheep, Haemonchus contortus. These compounds did not show overt cytotoxicity to a range of mammalian cell lines under standard in vitro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8c0ce81985631a42c44c923ffeabc447
https://doi.org/10.1021/acs.jmedchem.0c01793

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Novel 1-Methyl-1H-pyrazole-5-carboxamide Derivatives with Potent Anthelmintic Activity

Autor: Banfeng Ruan, Sarah Preston, Robin B. Gasser, Andreas Hofmann, Thuy G. Le, Timothy N. C. Wells, Lian Xue, Bill C.H. Chang, Jonathan B. Baell, Atanu Ghoshal, Yaqing Jiao, Jennifer Keiser, Abdul Jabbar, Abhijit Kundu, Michael J. Palmer, Fei Huang, Jose F. Garcia-Bustos, Nghi H. Nguyen

Publikováno v: Journal of Medicinal Chemistry. 62:3367-3380

A phenotypic screen of two different libraries of small molecules against the motility and development of the parasitic nematode Haemonchus contortus led to the identification of two 1-methyl-1 H-pyrazole-5-carboxamide derivatives. Medicinal chemistr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b8ec0aabd56da454bf5c14abff0c0eb
https://doi.org/10.1021/acs.jmedchem.8b01790

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Structure–Activity Relationship Studies of Tolfenpyrad Reveal Subnanomolar Inhibitors of Haemonchus contortus Development

Autor: Thuy G. Le, Nghi H. Nguyen, Jose F. Garcia-Bustos, Yaqing Jiao, Andreas Hofmann, Banfeng Ruan, Abdul Jabbar, Abhijit Kundu, Robin B. Gasser, Jonathan B. Baell, Sarah Preston, Timothy N. C. Wells, Bill C.H. Chang, Atanu Ghoshal, Fei Huang, Michael J. Palmer, Jennifer Keiser, Lian Xue

Publikováno v: Journal of Medicinal Chemistry. 62:1036-1053

Recently, we have discovered that the registered pesticide, tolfenpyrad, unexpectedly and potently inhibits the development of the L4 larval stage of the parasitic nematode Haemonchus contortus with an IC50 value of 0.03 μM while displaying good sel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47491ab1c7d20250ab7a12c0a1392ab5
https://doi.org/10.1021/acs.jmedchem.8b01789

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Optimization of Novel 1-Methyl-1 H-Pyrazole-5-carboxamides Leads to High Potency Larval Development Inhibitors of the Barber's Pole Worm

Autor: Yaqing Jiao, Banfeng Ruan, Jonathan B. Baell, Sarah Preston, Jose F. Garcia-Bustos, Fei Huang, Michael J. Palmer, Thuy G. Le, Bill C.H. Chang, Abhijit Kundu, Atanu Ghoshal, Jennifer Keiser, Robin B. Gasser, Abdul Jabbar, Andreas Hofmann, Timothy N. C. Wells, Nghi H. Nguyen, Lian Xue

Publikováno v: Journal of medicinal chemistry. 61(23)

A phenotypic screen of a diverse library of small molecules for inhibition of the development of larvae of the parasitic nematode Haemonchus contortus led to the identification of a 1-methyl-1H-pyrazole-5-carboxamide derivative with an IC50 of 0.29 �

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d057e59dbefa6c19d2f88d5f50852099
https://pubmed.ncbi.nlm.nih.gov/30403349

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MgSiO3 NPs catalyzed intramolecular cycloaddition reaction: A simple and stereoselective synthesis of unprecedented julolidine analogs

Autor: Vijayakumar G. Revanasiddappa, Suman Y. Reddy, Atanu Ghoshal, Subramanya Gopal Hegde, Lokesh Koodlur, H. Nagabhushana, Suchetan Parameshwar Adimule

A new julolidine hybrid analogs have been accomplished in a regio and stereo controlled manner using heterogenous MgSiO3 nanoparticles (NPs) catalyzed intramolecular dipolar cycloaddition reaction as a key step. The synthesized catalyst was used in t

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A facile stereoselective synthesis of julolidine hybrid analogs via domino knoevenagel intramolecular hetero Diels–Alder reaction

Autor: R. Senthil Kumaran, Subramanya Hegde, Govindaswamy Manickam, Atanu Ghoshal, Jayadevan Jayashankaran, Asit R. Sarkar

Publikováno v: Tetrahedron Letters. 53:1748-1752

We have reported here a facile stereoselective synthesis of julolidine hybrid analogs by employing domino Knoevenagel intramolecular hetero Diels–Alder reaction on symmetrical 1,3-diones and unsymmetrical 1,3-diones It was found that the cycloaddit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cf921ab7468664c97bec69ba31d4ce1d
https://doi.org/10.1016/j.tetlet.2012.01.103

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Rhodium-Catalyzed Asymmetric Hydrosilylation of Ketones Employing a New Ligand Embodying the Bis(oxazolinyl)pyridine Moiety

Autor: Jayadevan Jayashankaran, Atanu Ghoshal, R. Senthil Kumaran, Govindaswamy Manickam, Asit R. Sarkar

Publikováno v: Synlett. 2010:1459-1462

A general approach to new ligands embodying bis(oxazolinyl)pyridine has been developed, employing palladium-catalyzed Suzuki coupling and base-mediated cyclization as pivotal steps. A rhodium catalyst derived from the ligand 4-(4-ethylphenyl)-2,6-bis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2f1d42fdc7ab7a54545a12f24efb5251
https://doi.org/10.1055/s-0029-1219949

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ChemInform Abstract: A Facile Stereoselective Synthesis of Julolidine Hybrid Analogues via Domino Knoevenagel Intramolecular Hetero Diels-Alder Reaction

Autor: Asit R. Sarkar, Jayadevan Jayashankaran, Atanu Ghoshal, R. Senthil Kumaran, Govindaswamy Manickam, Subramanya Hegde

Publikováno v: ChemInform. 43

Microwave-assisted reaction of julolidine derivative (II) with symmetrical 1,3-dienes results in the highly stereoselective formation of products (III) and (V) via domino Knoevenagel/intramolecular hetero Diels—Alder reaction.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f4e02a7ffac13f52d0c795f14cbdb23a
https://doi.org/10.1002/chin.201230216

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ChemInform Abstract: Rhodium-Catalyzed Asymmetric Hydrosilylation of Ketones Employing a New Ligand Embodying the Bis(oxazolinyl)pyridine Moiety

Autor: Asit R. Sarkar, Govindaswamy Manickam, Atanu Ghoshal, R. Senthil Kumaran, Jayadevan Jayashankaran

Publikováno v: ChemInform. 41

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::16662bff4f4ff125f19db32bc48ef850
https://doi.org/10.1002/chin.201043066

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