Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Atakan Ekiz"'
Autor:
Yinshen Wee, Junhua Wang, Emily C. Wilson, Coulson P. Rich, Aaron Rogers, Zongzhong Tong, Evelyn DeGroot, Y. N. Vashisht Gopal, Michael A. Davies, H. Atakan Ekiz, Joshua K. H. Tay, Chris Stubben, Kenneth M. Boucher, Juan M. Oviedo, Keke C. Fairfax, Matthew A. Williams, Sheri L. Holmen, Roger K. Wolff, Allie H. Grossmann
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Tumour-host immune interactions lead to complex changes in the tumour microenvironment (TME), impacting progression, metastasis and response to therapy. While it is clear that cancer cells can have the capacity to alter immune landscapes, ou
Externí odkaz:
https://doaj.org/article/e7e3f29dc417478dac14dd2ee69fe482
Autor:
Sandra D. Scherer, Alessandra I. Riggio, Fadi Haroun, Yoko S. DeRose, H. Atakan Ekiz, Maihi Fujita, Jennifer Toner, Ling Zhao, Zheqi Li, Steffi Oesterreich, Ahmed A. Samatar, Alana L. Welm
Publikováno v:
Breast Cancer Research, Vol 23, Iss 1, Pp 1-18 (2021)
Abstract Background Metastatic breast cancer (MBC) is incurable, with a 5-year survival rate of 28%. In the USA, more than 42,000 patients die from MBC every year. The most common type of breast cancer is estrogen receptor-positive (ER+), and more pa
Externí odkaz:
https://doaj.org/article/9f5a018b7d5f4111b5c00b06970d1c1d
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
The rising toll of cancer globally necessitates ingenuity in early detection and therapy. In the last decade, the utilization of immune signatures and immune-based therapies has made significant progress in the clinic; however, clinical standards lea
Externí odkaz:
https://doaj.org/article/e139d0f509124008a685df0dc9188772
Autor:
Wei Feng Ma, Adam W. Turner, Christina Gancayco, Doris Wong, Yipei Song, Jose Verdezoto Mosquera, Gaëlle Auguste, Chani J. Hodonsky, Ajay Prabhakar, H. Atakan Ekiz, Sander W. van der Laan, Clint L. Miller
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 9 (2022)
Single-cell RNA-seq (scRNA-seq) is a powerful genomics technology to interrogate the cellular composition and behaviors of complex systems. While the number of scRNA-seq datasets and available computational analysis tools have grown exponentially, th
Externí odkaz:
https://doaj.org/article/89d0a6900b2d4ccca5ec751d0190c2cc
Autor:
Thomas B. Huffaker, H. Atakan Ekiz, Cindy Barba, Soh-Hyun Lee, Marah C. Runtsch, Morgan C. Nelson, Kaylyn M. Bauer, William W. Tang, Timothy L. Mosbruger, James E. Cox, June L. Round, Warren P. Voth, Ryan M. O’Connell
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
IFNy can polarize macrophages in the tumour microenvironment to an inflammatory state and thereby contributes to their anti-tumour function. Here the authors show an underlying mechanism in this process is IFNy-driven STAT1 occupancy and activation o
Externí odkaz:
https://doaj.org/article/b194e57208eb4a39a01b6f84ed5db4cc
Publikováno v:
BMC Bioinformatics, Vol 21, Iss 1, Pp 1-15 (2020)
Abstract Background Single cell RNA sequencing (scRNAseq) has provided invaluable insights into cellular heterogeneity and functional states in health and disease. During the analysis of scRNAseq data, annotating the biological identity of cell clust
Externí odkaz:
https://doaj.org/article/7e9500ca7bf24a8c93709e7e6bc3067a
Autor:
W. Zac Stephens, Jason L. Kubinak, Arevik Ghazaryan, Kaylyn M. Bauer, Rickesha Bell, Kate Buhrke, Tyson R. Chiaro, Allison M. Weis, William W. Tang, Josh K. Monts, Ray Soto, H. Atakan Ekiz, Ryan M. O’Connell, June L. Round
Publikováno v:
Cell Reports, Vol 37, Iss 5, Pp 109916- (2021)
Summary: Intestinal epithelial cells (IECs) have long been understood to express high levels of major histocompatibility complex class II (MHC class II) molecules but are not considered canonical antigen-presenting cells, and the impact of IEC-MHC cl
Externí odkaz:
https://doaj.org/article/c1e5d4d89cc84888a5fa9fbe24b048c9
Autor:
Diana Cortés-Selva, Lisa Gibbs, Andrew Ready, H Atakan Ekiz, Ryan O'Connell, Bartek Rajwa, Keke C Fairfax
Publikováno v:
PLoS Pathogens, Vol 17, Iss 2, p e1009260 (2021)
Epidemiological studies have identified a correlation between maternal helminth infections and reduced immunity to some early childhood vaccinations, but the cellular basis for this is poorly understood. Here, we investigated the effects of maternal
Externí odkaz:
https://doaj.org/article/446d0b8b30734010a24e8f897ced3428
Autor:
Jacob W. Thompson, Ruozhen Hu, Thomas B. Huffaker, Andrew G. Ramstead, H. Atakan Ekiz, Kaylyn M. Bauer, William W. Tang, Arevik Ghazaryan, June L. Round, Robert S. Fujinami, Ryan M. O’Connell
Publikováno v:
The Journal of Immunology. 210:926-934
The proinflammatory microRNA-155 (miR-155) is highly expressed in the serum and CNS lesions of patients with multiple sclerosis (MS). Global knockout (KO) of miR-155 in mice confers resistance to a mouse model of MS, experimental autoimmune encephalo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c53bba1a134ba5dc42deaaf2cfbc8551
https://doi.org/10.4049/jimmunol.2200478
https://doi.org/10.4049/jimmunol.2200478
Autor:
Andrew G. Ramstead, Jared A. Wallace, Soh-Hyun Lee, Kaylyn M. Bauer, William W. Tang, H. Atakan Ekiz, Thomas E. Lane, Ahmad A. Cluntun, Matthew L. Bettini, June L. Round, Jared Rutter, Ryan M. O’Connell
Publikováno v:
Cell Reports, Vol 30, Iss 9, Pp 2889-2899.e6 (2020)
Summary: Metabolic pathways regulate T cell development and function, but many remain understudied. Recently, the mitochondrial pyruvate carrier (MPC) was identified as the transporter that mediates pyruvate entry into mitochondria, promoting pyruvat
Externí odkaz:
https://doaj.org/article/85eca401df46476092567316c9937106