Zobrazeno 1 - 10
of 7 508
pro vyhledávání: '"At, Hattersley"'
Autor:
Rochelle N. Naylor, Kashyap A. Patel, Jarno L. T. Kettunen, Jonna M. E. Männistö, Julie Støy, Jacques Beltrand, Michel Polak, ADA/EASD PMDI, Tina Vilsbøll, Siri A. W. Greeley, Andrew T. Hattersley, Tiinamaija Tuomi
Publikováno v:
Communications Medicine, Vol 4, Iss 1, Pp 1-17 (2024)
Abstract Background Beta-cell monogenic forms of diabetes have strong support for precision medicine. We systematically analyzed evidence for precision treatments for GCK-related hyperglycemia, HNF1A-, HNF4A- and HNF1B-diabetes, and mitochondrial dia
Externí odkaz:
https://doaj.org/article/c6131c68651d4205b6f18e53add807da
Autor:
Ailsa MacCalman, Elisa De Franco, Alice Franklin, Christine S. Flaxman, Sarah J. Richardson, Kathryn Murrall, Joe Burrage, Barts Pancreas Tissue Bank (BPTB), Emma M. Walker, Noel G. Morgan, Andrew T. Hattersley, Emma L. Dempster, Eilis Hannon, Aaron R. Jeffries, Nick D. L. Owens, Jonathan Mill
Publikováno v:
BMC Genomics, Vol 25, Iss 1, Pp 1-18 (2024)
Abstract Development of the human pancreas requires the precise temporal control of gene expression via epigenetic mechanisms and the binding of key transcription factors. We quantified genome-wide patterns of DNA methylation in human fetal pancreati
Externí odkaz:
https://doaj.org/article/ea742da1a75a4ea5b89b8681cb5b5745
Autor:
Pedro Cardoso, Timothy J. McDonald, Kashyap A. Patel, Ewan R. Pearson, Andrew T. Hattersley, Beverley M. Shields, Trevelyan J. McKinley
Publikováno v:
BMC Medical Research Methodology, Vol 24, Iss 1, Pp 1-17 (2024)
Abstract Background Clinical prediction models can help identify high-risk patients and facilitate timely interventions. However, developing such models for rare diseases presents challenges due to the scarcity of affected patients for developing and
Externí odkaz:
https://doaj.org/article/c97bb83cbf934f38bba047a2417f6b8e
Autor:
Beverley M. Shields, Annelie Carlsson, Kashyap Patel, Julieanne Knupp, Akaal Kaur, Des Johnston, Kevin Colclough, Helena Elding Larsson, Gun Forsander, Ulf Samuelsson, Andrew Hattersley, Johnny Ludvigsson
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-9 (2024)
Abstract Maturity Onset Diabetes of the Young (MODY) is a young-onset, monogenic form of diabetes without needing insulin treatment. Diagnostic testing is expensive. To aid decisions on who to test, we aimed to develop a MODY probability calculator f
Externí odkaz:
https://doaj.org/article/7dd0725abec34703999b9a6ee43f95bd
Autor:
Liam Smeeth, Moffat J Nyirenda, Andrew T Hattersley, Angus G Jones, Jean-Claude Katte, Isaac Sekitoleko, Davis Kibirige, Anita V Hill, William Lumu, Julieanne Knupp, Steven Squires
Publikováno v:
BMJ Open Diabetes Research & Care, Vol 12, Iss 4 (2024)
Introduction We undertook phenotypic characterization of early-onset and late-onset type 2 diabetes (T2D) in adult black African and white European populations with recently diagnosed T2D to explore ethnic differences in the manifestation of early-on
Externí odkaz:
https://doaj.org/article/f9ec137eb455418f9da989cc89bf1feb
Autor:
Corbin Griffen, Tom Cullen, John Hattersley, Martin O. Weickert, Alexander Dallaway, Michael Duncan, Derek Renshaw
Publikováno v:
Experimental Gerontology, Vol 193, Iss , Pp 112477- (2024)
Purpose: Ageing is associated with cognitive decline. This study investigated the individual and combined effects of resistance exercise (RE) and whey protein supplementation (PRO) on cognitive function in older men. Methods: In a pooled-groups analy
Externí odkaz:
https://doaj.org/article/ece0f9d533dc4a32b01a8a61c65dd865
Autor:
Davis Kibirige, Isaac Sekitoleko, William Lumu, Nihal Thomas, Meredith Hawkins, Angus G. Jones, Andrew T. Hattersley, Liam Smeeth, Moffat J. Nyirenda
Publikováno v:
Therapeutic Advances in Endocrinology and Metabolism, Vol 15 (2024)
Background: Type 2 diabetes is common in relatively lean individuals in sub-Saharan Africa. It is unclear whether phenotypic differences exist between underweight and normal-weight African patients with type 2 diabetes. This study compared specific c
Externí odkaz:
https://doaj.org/article/4555654942614ba3b08936c811f1afbc
Autor:
Griffen, Corbin, Cullen, Tom, Hattersley, John, Weickert, Martin O., Dallaway, Alexander, Duncan, Michael, Renshaw, Derek
Publikováno v:
In Experimental Gerontology August 2024 193
Autor:
Maria Carolina Borges, Gemma L. Clayton, Rachel M. Freathy, Janine F. Felix, Alba Fernández-Sanlés, Ana Gonçalves Soares, Fanny Kilpi, Qian Yang, Rosemary R. C. McEachan, Rebecca C. Richmond, Xueping Liu, Line Skotte, Amaia Irizar, Andrew T. Hattersley, Barbara Bodinier, Denise M. Scholtens, Ellen A. Nohr, Tom A. Bond, M. Geoffrey Hayes, Jane West, Jessica Tyrrell, John Wright, Luigi Bouchard, Mario Murcia, Mariona Bustamante, Marc Chadeau-Hyam, Marjo-Riitta Jarvelin, Martine Vrijheid, Patrice Perron, Per Magnus, Romy Gaillard, Vincent W. V. Jaddoe, William L. Lowe, Bjarke Feenstra, Marie-France Hivert, Thorkild I. A. Sørensen, Siri E. Håberg, Sylvain Serbert, Maria Magnus, Deborah A. Lawlor
Publikováno v:
BMC Medicine, Vol 22, Iss 1, Pp 1-14 (2024)
Abstract Background Higher maternal pre-pregnancy body mass index (BMI) is associated with adverse pregnancy and perinatal outcomes. However, whether these associations are causal remains unclear. Methods We explored the relation of maternal pre-/ear
Externí odkaz:
https://doaj.org/article/0a4789dc4d5f4384bda3a38300dc1bb0
Autor:
WD Thompson, RM Reynolds, RN Beaumont, NM Warrington, J Tyrrell, AR Wood, DM Evans, TJ McDonald, AH Hattersley, RM Freathy, DA Lawlor, MC Borges
Publikováno v:
BMC Pregnancy and Childbirth, Vol 24, Iss 1, Pp 1-11 (2024)
Abstract Background Observational studies and randomized controlled trials have found evidence that higher maternal circulating cortisol levels in pregnancy are associated with lower offspring birth weight. However, it is possible that the observatio
Externí odkaz:
https://doaj.org/article/184b224809554cf29e490e6fb1d795b3