Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Asylkhan Rakhymzhan"'
Autor:
Till Fabian Mertens, Alina Tabea Liebheit, Johanna Ehl, Ralf Köhler, Asylkhan Rakhymzhan, Andrew Woehler, Lukas Katthän, Gernot Ebel, Wjatscheslaw Liublin, Ana Kasapi, Antigoni Triantafyllopoulou, Tim Julius Schulz, Raluca Aura Niesner, Anja Erika Hauser
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Analyzing immune cell interactions in the bone marrow is vital for understanding hematopoiesis and bone homeostasis. Three-dimensional analysis of the complete, intact bone marrow within the cortex of whole long bones remains a challenge, es
Externí odkaz:
https://doaj.org/article/ce98ba8479a34113a4359a3ee8fa5a81
Autor:
Christian H. Gabriel, Marta del Olmo, Amin Zehtabian, Marten Jäger, Silke Reischl, Hannah van Dijk, Carolin Ulbricht, Asylkhan Rakhymzhan, Thomas Korte, Barbara Koller, Astrid Grudziecki, Bert Maier, Andreas Herrmann, Raluca Niesner, Tomasz Zemojtel, Helge Ewers, Adrián E. Granada, Hanspeter Herzel, Achim Kramer
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Live-cell recordings have been an important tool for studying circadian rhythms. Here the authors use CRISPR gene editing mediated knock-in to fluorescently tag Per2 and Cry1, and study cellular circadian dynamics of these two clock proteins.
Externí odkaz:
https://doaj.org/article/b3b650cbf5af40ee9a15a843fab1524b
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 21, p 13407 (2022)
Two-photon excitation fluorescence laser-scanning microscopy is the preferred method for studying dynamic processes in living organ models or even in living organisms. Thanks to near-infrared and infrared excitation, it is possible to penetrate deep
Externí odkaz:
https://doaj.org/article/8bcf942821974916af43b8802f9ca2f0
Autor:
Carolin Ulbricht, Ruth Leben, Asylkhan Rakhymzhan, Frank Kirchhoff, Lars Nitschke, Helena Radbruch, Raluca A Niesner, Anja E Hauser
Publikováno v:
eLife, Vol 10 (2021)
Calcium is a universal second messenger present in all eukaryotic cells. The mobilization and storage of Ca2+ ions drives a number of signaling-related processes, stress–responses, or metabolic changes, all of which are relevant for the development
Externí odkaz:
https://doaj.org/article/23cb8f32d40044f082c0f1a13df9a9ce
Autor:
Dorothea Reimer, Michael Meyer-Hermann, Asylkhan Rakhymzhan, Tobit Steinmetz, Philipp Tripal, Jana Thomas, Martin Boettcher, Dimitrios Mougiakakos, Sebastian R. Schulz, Sophia Urbanczyk, Anja E. Hauser, Raluca A. Niesner, Dirk Mielenz
Publikováno v:
Cell Reports, Vol 32, Iss 6, Pp 108030- (2020)
Summary: Plasma cells secreting affinity-matured antibodies develop in germinal centers (GCs), where B cells migrate persistently and directionally over defined periods of time. How modes of GC B cell migration influence plasma cell development remai
Externí odkaz:
https://doaj.org/article/1b38f80a110a4861a41f6604627db27e
Autor:
David Reismann, Jonathan Stefanowski, Robert Günther, Asylkhan Rakhymzhan, Romano Matthys, Reto Nützi, Sandra Zehentmeier, Katharina Schmidt-Bleek, Georg Petkau, Hyun-Dong Chang, Sandra Naundorf, York Winter, Fritz Melchers, Georg Duda, Anja E. Hauser, Raluca A. Niesner
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Longitudinal imaging of bone marrow would shed insight into long-term cellular dynamics within this compartment. Here, the authors develop a multi-photon imaging approach for the mouse femur and reveal extensive vascular plasticity within the bone ma
Externí odkaz:
https://doaj.org/article/5461e2efd91248698ccbbea37bccb7fc
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 11, p 6046 (2021)
Two-photon microscopy enables monitoring cellular dynamics and communication in complex systems, within a genuine environment, such as living tissues and, even, living organisms. Particularly, its application to understand cellular interactions in th
Externí odkaz:
https://doaj.org/article/5d049c66536c4c73be654627e08dbb1e
Autor:
Asylkhan Rakhymzhan, Ruth Leben, Hanna Zimmermann, Robert Günther, Peggy Mex, David Reismann, Carolin Ulbricht, Andreas Acs, Alexander U. Brandt, Randall L. Lindquist, Thomas H. Winkler, Anja E. Hauser, Raluca A. Niesner
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-16 (2017)
Abstract Simultaneous detection of multiple cellular and molecular players in their native environment, one of the keys to a full understanding of immune processes, remains challenging for in vivo microscopy. Here, we present a synergistic strategy f
Externí odkaz:
https://doaj.org/article/b33b7358951648f988bec043ea650aa8
Autor:
Ruth Leben, Lennard Ostendorf, Sofie van Koppen, Asylkhan Rakhymzhan, Anja E. Hauser, Helena Radbruch, Raluca A. Niesner
Publikováno v:
International Journal of Molecular Sciences, Vol 19, Iss 4, p 1018 (2018)
Time-correlated single-photon counting combined with multi-photon laser scanning microscopy has proven to be a versatile tool to perform fluorescence lifetime imaging in biological samples and, thus, shed light on cellular functions, both in vitro an
Externí odkaz:
https://doaj.org/article/70951fc1ee274cccabb05ac410eed7db
Autor:
Asylkhan, Rakhymzhan, Andreas, Acs, Ruth, Leben, Thomas H, Winkler, Anja E, Hauser, Raluca A, Niesner
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2350
Intravital two-photon microscopy enables monitoring of cellular dynamics and communication of complex systems, in genuine environment-the living organism. Particularly, its application in understanding the immune system brought unique insights into p