Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Asya Stepansky"'
Autor:
Angel E Dago, Asya Stepansky, Anders Carlsson, Madelyn Luttgen, Jude Kendall, Timour Baslan, Anand Kolatkar, Michael Wigler, Kelly Bethel, Mitchell E Gross, James Hicks, Peter Kuhn
Publikováno v:
PLoS ONE, Vol 9, Iss 8, p e101777 (2014)
Timely characterization of a cancer's evolution is required to predict treatment efficacy and to detect resistance early. High content analysis of single Circulating Tumor Cells (CTCs) enables sequential characterization of genotypic, morphometric an
Externí odkaz:
https://doaj.org/article/777ce00953e94db8ba1aa741b3ad78d0
Autor:
Alexander Krasnitz, Michael Wigler, James Hicks, Herbert Lepor, Lloyd C. Trotman, Gurinder Atwal, Brian Robinson, Shalini S. Yadav, Siobhan Gruschow, Abhishek Srivastava, Elton Llukani, Juliana Laze, Dawid G. Nowak, Inessa Hakker, Hilary Cox, Michael Riggs, Lubomir Chobardjiev, Guoli Sun, Asya Stepansky, Dan Levy, Robert Aboukhalil, Linda Rodgers, Jean McIndoo, Jude Kendall, Joan Alexander
Summary of downsampling study
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17b90e9d98bd16d082d42ce320dc0531
https://doi.org/10.1158/0008-5472.22417632.v1
https://doi.org/10.1158/0008-5472.22417632.v1
Autor:
Alexander Krasnitz, Michael Wigler, James Hicks, Herbert Lepor, Lloyd C. Trotman, Gurinder Atwal, Brian Robinson, Shalini S. Yadav, Siobhan Gruschow, Abhishek Srivastava, Elton Llukani, Juliana Laze, Dawid G. Nowak, Inessa Hakker, Hilary Cox, Michael Riggs, Lubomir Chobardjiev, Guoli Sun, Asya Stepansky, Dan Levy, Robert Aboukhalil, Linda Rodgers, Jean McIndoo, Jude Kendall, Joan Alexander
A distinction between indolent and aggressive disease is a major challenge in diagnostics of prostate cancer. As genetic heterogeneity and complexity may influence clinical outcome, we have initiated studies on single tumor cell genomics. In this stu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0825d02064561e7384a09d17d723523f
https://doi.org/10.1158/0008-5472.c.6509898.v1
https://doi.org/10.1158/0008-5472.c.6509898.v1
Autor:
Alexander Krasnitz, Michael Wigler, James Hicks, Herbert Lepor, Lloyd C. Trotman, Gurinder Atwal, Brian Robinson, Shalini S. Yadav, Siobhan Gruschow, Abhishek Srivastava, Elton Llukani, Juliana Laze, Dawid G. Nowak, Inessa Hakker, Hilary Cox, Michael Riggs, Lubomir Chobardjiev, Guoli Sun, Asya Stepansky, Dan Levy, Robert Aboukhalil, Linda Rodgers, Jean McIndoo, Jude Kendall, Joan Alexander
A PDF file containing Supplementary case reports
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::595e3a79f42024e6afccafcf6b102662
https://doi.org/10.1158/0008-5472.22417626.v1
https://doi.org/10.1158/0008-5472.22417626.v1
Autor:
Andrea B Moffitt, Joan Alexander, Asya Stepansky, Christopher Famulare, Carlos A Lopez, Nausheen Hakim, Vernon Wu, Zihua Wang, Jonathan E. Kolitz, Nicholas Chiorazzi, Steven L Allen, Ross L. Levine, Dan Levy, Michael Wigler
Publikováno v:
Blood. 140:9167-9169
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ed777d111b682f4dd56c42c9571a2c22
https://doi.org/10.1182/blood-2022-163607
https://doi.org/10.1182/blood-2022-163607
Autor:
Zihua Wang, Nicholas Chiorazzi, Jude Kendall, Joan Alexander, Steven L. Allen, Peter Andrews, Beicong Ma, Mona S. Spector, Asya Stepansky, Michael Wigler, Jonathan E. Kolitz, Alexander Krasnitz, Dan Levy, Andrea B. Moffitt
Publikováno v:
Nucleic Acids Research
Measuring minimal residual disease in cancer has applications for prognosis, monitoring treatment and detection of recurrence. Simple sequence-based methods to detect nucleotide substitution variants have error rates (about 10−3) that limit sensiti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b99db5e5239c935d23a32ff90278e7a
https://pubmed.ncbi.nlm.nih.gov/32083660
https://pubmed.ncbi.nlm.nih.gov/32083660
Autor:
James W. Hicks, Inessa Hakker, Gurinder S. Atwal, Jude Kendall, Joan Alexander, Linda Rodgers, Lubomir Chobardjiev, Shalini S. Yadav, Dan Levy, Robert Aboukhalil, Asya Stepansky, Lloyd C. Trotman, Brian D. Robinson, Michael Wigler, Abhishek Kumar Srivastava, Michael Riggs, Elton Llukani, Alexander Krasnitz, Juliana Laze, Siobhan Gruschow, Herbert Lepor, Jean McIndoo, Guoli Sun, Hilary Cox, Dawid G. Nowak
Publikováno v:
Cancer Research. 78:348-358
A distinction between indolent and aggressive disease is a major challenge in diagnostics of prostate cancer. As genetic heterogeneity and complexity may influence clinical outcome, we have initiated studies on single tumor cell genomics. In this stu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2aa8d57485a99210baf0d0374e2af08e
https://doi.org/10.1158/0008-5472.can-17-1138
https://doi.org/10.1158/0008-5472.can-17-1138
Autor:
Luciano G. Martelotto, Jorge S. Reis-Filho, Britta Weigelt, Hannah Y Wen, Kathleen A. Burke, Asya Stepansky, Linda Rodgers, Larry Norton, Pamela Moody, Michail Schizas, Salvatore Piscuoglio, Felipe C Geyer, James W. Hicks, Timour Baslan, Sean D'Italia, Lee Spraggon, Gouri Nanjangud, Charlotte K.Y. Ng, Jude Kendall, Tari A. King, Arnaud Da Cruz Paula, Hilary Cox, Kalyani Chadalavada
Publikováno v:
Nature medicine
A substantial proportion of tumors consist of genotypically distinct subpopulations of cancer cells. This intratumor genetic heterogeneity poses a substantial challenge for the implementation of precision medicine. Single-cell genomics constitutes a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2df1eba8d4389693e07806880a1ccfc
http://europepmc.org/articles/PMC5608257
http://europepmc.org/articles/PMC5608257
Autor:
Anthony Leotta, Steven Marks, Ivan Iossifov, Lucinda Fulton, Kith Pradhan, Peter Andrews, Linda Rodgers, Michael Wigler, Beicong Ma, Richard W. McCombie, Jennifer Troge, Elena Ghiban, Ryan Demeter, Robert S. Fulton, Julie Rosenbaum, Asya Stepansky, Vincent Magrini, Yoon-ha Lee, Kenny Ye, Jennifer Parla, Richard K. Wilson, Robert B. Darnell, Boris Yamrom, Inessa Hakker, Jennifer C. Darnell, Michael Ronemus, Michael C. Schatz, Dan Levy, Elaine R. Mardis, Zihua Wang, Giuseppe Narzisi, Melissa Kramer, Jude Kendall, Mitchell A. Bekritsky, Ewa A. Grabowska
Publikováno v:
Neuron. 74(2):285-299
SummaryExome sequencing of 343 families, each with a single child on the autism spectrum and at least one unaffected sibling, reveal de novo small indels and point substitutions, which come mostly from the paternal line in an age-dependent manner. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::436dac00dfb388b306cc1884918b76cf
Autor:
Asya Stepansky, Michael Wigler, Alexander Krasnitz, Peter Andrews, Linda Rodgers, Jeanne McIndoo, James W. Hicks, Lakshmi Muthuswamy, Jennifer Troge, W. Richard McCombie, Diane Esposito, Dan Levy, Jude Kendall, Nicholas Navin, Kerry Cook
Publikováno v:
Nature. 472:90-94
Genomic analysis provides insights into the role of copy number variation in disease, but most methods are not designed to resolve mixed populations of cells. In tumours, where genetic heterogeneity is common, very important information may be lost t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27c77abf75d4cdd380a351490194957a
https://doi.org/10.1038/nature09807
https://doi.org/10.1038/nature09807