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pro vyhledávání: '"Asya Martirosyan"'
Reducing the metabolic burden of rRNA synthesis promotes healthy longevity in Caenorhabditis elegans
Autor:
Samim Sharifi, Prerana Chaudhari, Asya Martirosyan, Alexander Otto Eberhardt, Finja Witt, André Gollowitzer, Lisa Lange, Yvonne Woitzat, Eberechukwu Maryann Okoli, Huahui Li, Norman Rahnis, Joanna Kirkpatrick, Oliver Werz, Alessandro Ori, Andreas Koeberle, Holger Bierhoff, Maria Ermolaeva
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Ribosome biogenesis is initiated by RNA polymerase I (Pol I)-mediated synthesis of pre-ribosomal RNA (pre-rRNA). Pol I activity was previously linked to longevity, but the underlying mechanisms were not studied beyond effects on nucleolar st
Externí odkaz:
https://doaj.org/article/e8c06c7d253c4ce7a8ddf6f0c29bac62
Autor:
Norman Rahnis, Alexander Dakhovnik, Maria Ermolaeva, Prerana Chaudhari, Joanna Kirkpatrick, Lilia Espada, Ashish Nair, Tetiana Poliezhaieva, Oliver Werz, Asya Martirosyan, Laura Miek, Nadia Döring, Yvonne Schaub, Andreas Koeberle, Alessandro Ori
Publikováno v:
Nature metabolism. 2(11)
Current clinical trials are testing the life-extending benefits of the diabetes drug metformin in healthy individuals without diabetes. However, the metabolic response of a non-diabetic cohort to metformin treatment has not been studied. Here, we sho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3b50125244efa90bb3a63f36ef26dd9
https://pubmed.ncbi.nlm.nih.gov/33139960
https://pubmed.ncbi.nlm.nih.gov/33139960