Zobrazeno 1 - 9 of 9 pro vyhledávání: '"Aswin K. Garimallaprabhakaran"'
1
Importance of lipophilicity for potent anti-herpes simplex virus-1 activity of α-hydroxytropolones
Autor: Alex J. Berkowitz, Aswin K. Garimallaprabhakaran, Lynda A. Morrison, Alice J. Yu, Andreu Gazquez Cassals, Abaigeal D. Franson, Katherine A. Donald, Ryan P. Murelli
Publikováno v: Medchemcomm
We previously reported that troponoid compounds profoundly inhibit replication of herpes simplex virus (HSV)-1 and HSV-2 in cell culture, including acyclovir-resistant mutants. Synthesis of 26 alpha-hydroxylated tropolones (αHTs) led to a preliminar
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e439bbfdfc2d6af1d45585fcc4cfcf32
https://doi.org/10.1039/c9md00225a
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2
Maltol- and Allomaltol-Derived Oxidopyrylium Ylides: Methyl Substitution Pattern Kinetically Influences [5 + 3] Dimerization versus [5 + 2] Cycloaddition Reactions
Autor: Lauren P. Bejcek, William H. Hersh, Duygu M. Suyabatmaz, Aswin K. Garimallaprabhakaran, Alexander Greer, Edyta M. Greer, Ryan P. Murelli
Publikováno v: J Org Chem
Oxidopyrylium ylides are useful intermediates in synthetic organic chemistry because of their capability of forming structurally complex cycloadducts. They can also self-dimerize via [5 + 3] cycloaddition, which is an oft-reported side reaction that
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da0b79c1e52a0a7986be2befb08f3d6d
https://pubmed.ncbi.nlm.nih.gov/31603325
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3
Efficacy and cytotoxicity in cell culture of novel α-hydroxytropolone inhibitors of hepatitis B virus ribonuclease H
Autor: Ryan P. Murelli, Yashkumar Ashani, John E. Tavis, Nana B. Agyemang, Aswin K. Garimallaprabhakaran, Jil Daw, Elena Lomonosova
Publikováno v: Antiviral research. 144
Chronic Hepatitis B virus (HBV) infection is a major worldwide public health problem. Current direct-acting anti-HBV drugs target the HBV DNA polymerase activity, but the equally essential viral ribonuclease H (RNaseH) activity is unexploited as a dr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17c2b4039c03c638d59c21a9a7864793
https://pubmed.ncbi.nlm.nih.gov/28633989
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4
Troponoids Can Inhibit Growth of the Human Fungal Pathogen Cryptococcus neoformans
Autor: Anthony Zunica, John E. Tavis, Maureen J. Donlin, Alex J. Berkowitz, Ashlyn Lipnicky, Aswin K. Garimallaprabhakaran, Marvin J. Meyers, Ryan P. Murelli, Alexandre Grigoryan
Publikováno v: Antimicrobial Agents and Chemotherapy. 61
Cryptococcus neoformans is a pathogen that is common in immunosuppressed patients. It can be treated with amphotericin B and fluconazole, but the mortality rate remains 15 to 30%. Thus, novel and more effective anticryptococcal therapies are needed.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36b013399b41c2e0e01e6962d4d3535c
https://doi.org/10.1128/aac.02574-16
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5
CH Activation in S-Alkenyl Sulfoximines: An Endo 1,5-Hydrogen Migration
Autor: Xuefeng Gao, Michael Harmata, Zhengxin Cai, Aswin K. Garimallaprabhakaran, Erich Altenhofer, Vikram Gaddam, Nattawut Yongpruksa, Rama Rao Tata
Publikováno v: Angewandte Chemie International Edition. 51:7016-7019
Intramolecular redox reaction: heating N-alkyl, N-allyl-, and N-benzyl-substituted S-alkenyl sulfoximines under appropriate conditions results in the formation of NH-S-alkyl sulfoximines. The intramolecular redox reaction involves a hydride transfer
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bc7bb14dfb101f44ffeaac37009f3fa
https://doi.org/10.1002/anie.201203258
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