Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Aswath P Chandrasekar"'
Autor:
Andrea J French, Sekar Natesampillai, Ashton Krogman, Cristina Correia, Kevin L Peterson, Alecia Alto, Aswath P Chandrasekar, Anisha Misra, Ying Li, Scott H Kaufmann, Andrew D Badley, Nathan W Cummins
Publikováno v:
PLoS Pathogens, Vol 16, Iss 10, p e1008906 (2020)
Eradication of HIV-1 by the "kick and kill" strategy requires reactivation of latent virus to cause death of infected cells by either HIV-induced or immune-mediated apoptosis. To date this strategy has been unsuccessful, possibly due to insufficient
Externí odkaz:
https://doaj.org/article/43ec5f6e91a24ab2bbc1bd2c4e5d59c0
Autor:
Aswath P. Chandrasekar, Nathan W. Cummins, Sekar Natesampillai, Anisha Misra, Alecia Alto, Greg Laird, Andrew D. Badley
Publikováno v:
Journal of Virology. 96
This study is the first to examine the applicability of BCL-2 inhibition in the setting of active HIV infectionin vivo. Furthermore, this study demonstrates that venetoclax significantly enhances target cell killing induced by Fas ligand, TRAIL, and
Publikováno v:
Frontiers in immunology. 13
While modern HIV therapy can effectively suppress viral replication, the persistence of the latent reservoir posits the greatest hurdle to complete cure. The “shock and kill” strategy is under investigation for HIV therapy, aiming to reactivate l
Publikováno v:
Oncotarget
Autor:
Andrew D. Badley, Caitlin J. VanLith, Anisha Misra, Sekar Natesampillai, Ashton Krogman, Aswath P. Chandrasekar, Alecia Alto, F. N.U. Shweta, Nathan W. Cummins, Joseph D. Yao
Publikováno v:
J Virol
The antiapoptotic protein BCL2 inhibits death of HIV-infected cells. Previously, we showed that the BCL2 inhibitor venetoclax selectively kills acutely HIV-infected cells and reduces HIV DNA in latently infected CD4 T cells ex vivo after reactivation
Autor:
Andrew D. Badley, Aswath P. Chandrasekar, Ana C. Paim, Gary D. Bren, Hans-Peter Kiem, Sharon R Lewin, Nathan W. Cummins, Sekar Natesampillai
Publikováno v:
J Immunol
CD4 T cells from HIV-1 infected patients die at excessive rates compared to those from uninfected patients, causing immunodeficiency. We previously identified a dominant negative ligand that antagonizes the TRAIL-dependent pathway of cell death, whic
Autor:
Anisha Misra, Aswath P. Chandrasekar, Cristina Correia, Sekar Natesampillai, Andrew D. Badley, Nathan W. Cummins, Kevin L. Peterson, Scott H. Kaufmann, Ying Li, Alecia Alto, Andrea J. French, Ashton Krogman
Publikováno v:
PLoS Pathogens, Vol 16, Iss 10, p e1008906 (2020)
PLoS Pathogens
PLoS Pathogens
Eradication of HIV-1 by the “kick and kill” strategy requires reactivation of latent virus to cause death of infected cells by either HIV-induced or immune-mediated apoptosis. To date this strategy has been unsuccessful, possibly due to insuffici
Publikováno v:
Clin Microbiol Rev
Advances in HIV-1 therapy have transformed the once fatal infection into a manageable, chronic condition, yet the search for a widely applicable approach to cure remains elusive. The ineffectiveness of antiretroviral therapy (ART) in reducing the siz