Výsledky vyhledávání - "Asunción Muro"

Pharmacological properties of S1RA, a new sigma-1 receptor antagonist that inhibits neuropathic pain and activity-induced spinal sensitization

Publikováno v: British Journal of Pharmacology. 166:2289-2306

BACKGROUND AND PURPOSE The sigma-1 (σ(1) ) receptor is a ligand-regulated molecular chaperone that has been involved in pain, but there is limited understanding of the actions associated with its pharmacological modulation. Indeed, the selectivity a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::418c7ee746ab3902c87c38f7fc599662
https://doi.org/10.1111/j.1476-5381.2012.01942.x

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Immunohistochemical localization of the sigma1 receptor in Schwann cells of rat sciatic nerve

Autor: José Miguel Vela, Enric Verdú, Martí Pumarola, G. Palacios, Asunción Muro

Publikováno v: Brain Research. 1007:65-70

The sigma-1 (sigma(1)) receptors can bind different psychotropic drugs and have been implicated in schizophrenia, depression and dementia. The cloning of the sigma(1)-receptor has allowed to obtain specific antibodies and, in a recent immunohistochem

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28f102882e2a2cfa1a8895f876708344
https://doi.org/10.1016/j.brainres.2004.02.013

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Differential effects of haloperidol and two anxiolytic drugs, buspirone and lesopitron, on c-Fos expression in the rat striatum and nucleus accumbens

Autor: G. Palacios, Ana Paz Marín, Mª Asunción Muro

Publikováno v: Brain Research. 742:141-148

We have studied the effects of the neuroleptic haloperidol and the non-benzodiazepine anxiolytics buspirone and lesopitron on the expression of c-Fos immunoreactivity in the rat forebrain. Haloperidol and buspirone administration resulted in a signif

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78c8a5c49a1471a45289c80a4e600665
https://doi.org/10.1016/s0006-8993(96)00975-4

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Pharmacological activation of 5-HT7 receptors reduces nerve injury-induced mechanical and thermal hypersensitivity

Autor: Daniel Zamanillo, R. Sánchez-Arroyos, Rafael Maldonado, Marta Pujol, Xavier Codony, Luz Romero, Asunción Muro, Michel Hamon, Ana Montero, José Miguel Vela, Xavier Nadal, Enrique Portillo-Salido, Sergio Ovalle, Alex Brenchat, Javier Burgueño

Publikováno v: PainReferences. 149(3)

The involvement of the 5-HT(7) receptor in nociception and pain, particularly chronic pain (i.e., neuropathic pain), has been poorly investigated. In the present study, we examined whether the 5-HT(7) receptor participates in some modulatory control

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83c57fb8effabb415fe7cfb6c1bdfa36
https://pubmed.ncbi.nlm.nih.gov/20399562

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Sigma-1 receptors regulate activity-induced spinal sensitization and neuropathic pain after peripheral nerve injury

Autor: Beatriz de la Puente, G. Palacios, José Miguel Vela, José Manuel Entrena, Asunción Muro, José M. Baeyens, R. Sánchez-Arroyos, Rafael Maldonado, Daniel Zamanillo, Sergio Ovalle, Xavier Nadal, Enrique Portillo-Salido, J.A. Lopez-Garcia, Luz Romero

Publikováno v: PainReferences. 145(3)

Sigma-1 receptor (sigma(1)R) is expressed in key CNS areas involved in nociceptive processing but only limited information is available about its functional role. In the present study we investigated the relevance of sigma(1)R in modulating nerve inj

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d82a96be1bebbd40c3faeab076ba88b0
https://pubmed.ncbi.nlm.nih.gov/19577365

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Immunohistochemical localization of the sigma1-receptor in oligodendrocytes in the rat central nervous system

Autor: G. Palacios, Eduardo Molina-Holgado, Sergio Ovalle, Asunción Muro, José Miguel Vela, Xavier Guitart, Daniel Zamanillo

Publikováno v: Brain research. 961(1)

By using a new polyclonal antibody raised against a 21-amino acid peptide sequence corresponding to the fragment 138-157 of the cloned rat sigma(1)-receptor, we demonstrated by immunoperoxidase and double immunofluorescence techniques, that rat oligo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c2c54e60c71e5294a7426075d930e4d
https://pubmed.ncbi.nlm.nih.gov/12535781

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F149 PHARMACOLOGICAL OCCUPANCY OF THE SELECTIVE SIGMA1 RECEPTOR ANTAGONIST (S1RA) IN THE CNS: CORRELATION WITH EFFICACY IN MOUSE MODELS OF PAIN

Autor: D. Zamanillo, Xavier Nadal, Enrique Portillo-Salido, Asunción Muro, M. Laloya, J.M. Vela, R. Sánchez-Arroyos, Rafael Maldonado, C. Segalés, L. Romero

Publikováno v: European Journal of Pain Supplements. 5:117

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::90ec396881306bc9dfa22efb5e948b78
https://doi.org/10.1016/s1754-3207(11)70398-4

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192 THE LACK OF SIGMA-1 RECEPTOR LEADS TO REDUCED NEUROPATHIC PAIN BEHAVIOURS AND ACTIVITY-INDUCED SPINAL SENSITIZATION

Autor: B. De la Puente, G. Palacios, S. Ovalle, R. Sánchez-Arroyos, Rafael Maldonado, Xavier Nadal, J.M. Vela, Enrique Portillo-Salido, D. Zamanillo, José M. Baeyens, Asunción Muro, L. Romero, José Manuel Entrena, J.A. Lopez-Garcia

Publikováno v: European Journal of Pain Supplements. 4:57-57

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::91d32849f76625d9bd12c93dc4f90647
https://doi.org/10.1016/s1754-3207(10)70197-8

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