Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Asuka Takumi"'
Autor:
Yasuko Kawamata, Yusuke Shibui, Asuka Takumi, Takuya Seki, Tomoko Shimada, Masaki Hashimoto, Naohiko Inoue, Hisamine Kobayashi, Takahiro Narita
Publikováno v:
Toxicology Reports, Vol 7, Iss , Pp 1233-1241 (2020)
Wolffia is a genus of protein-rich aquatic plants. Mankai, a cultivated strain of Wolffia globosa, contains more than 40 % protein based on dry matter evaluation. Furthermore, Mankai is nutritionally excellent as a food material, and is expected to b
Externí odkaz:
https://doaj.org/article/23df76fa77484ccca285876f6e50b6cc
Autor:
Norimichi Hattori, Hideaki Yokoyama, Asuka Takumi, Sayaka Kawaguchi, Koki Yamaguchi, Taishi Shimazaki, Yusuke Shibui, Kosuke Saito, Yoshiro Saito
Publikováno v:
The Journal of toxicological sciences. 48(1)
Although microsampling of blood is recommended to promote the 3Rs in toxicokinetic (TK) evaluation, there are few reports applying microsampling in actual toxicity evaluation. Here, we assessed the effects of microsampling on toxicological evaluation
Publikováno v:
Journal of Toxicological Sciences. 2020, Vol. 45 Issue 10, p599-609. 11p.
Autor:
Yasuko Kawamata, Tomoko Shimada, Asuka Takumi, Yuri Ooba, Hidehiro Nakamura, Akiko Watanabe, Takahiro Narita, Johannes B. van Goudoever, Ryosei Sakai
Publikováno v:
Sakai, R, Ooba, Y, Watanabe, A, Nakamura, H, Kawamata, Y, Shimada, T, Takumi, A, van Goudoever, J B & Narita, T 2020, ' Glutamate metabolism in a human intestinal epithelial cell layer model ', Amino Acids, vol. 52, no. 11-12, pp. 1505-1519 . https://doi.org/10.1007/s00726-020-02908-2
Amino Acids, 52(11-12), 1505-1519. Springer Wien
Amino Acids, 52(11-12), 1505-1519. Springer Wien
Plasma glutamate concentrations are constant despite dynamic changes in diets. Most likely, virtually all the dietary glutamate is metabolized in the gut. The present study investigated permeability and metabolism of dietary glutamate in a Caco-2 int
Autor:
Hideaki Yokoyama, Eiji Murata, Fumihiro Jinno, Harumi Kitaura, Atsushi Iwai, Yoshiro Saito, Kyotaka Muta, Norimichi Hattori, Kosuke Saito, Kanae Mori, Hirohiko Ohtsuka, Akio Kobayashi, Asuka Takumi, Keiko Nakai
Publikováno v:
The Journal of Toxicological Sciences. 45:319-325
Due to finalization of the ICH S3A Q&A focusing on microsampling, application of microsampling technique to regular non-clinical animal studies is expected for non-clinical safety assessment of pharmaceuticals. In Europe, microsampling from the tail
Autor:
Tomoko Shimada, Yasuko Kawamata, Hisamine Kobayashi, Yusuke Shibui, Naohiko Inoue, Takahiro Narita, Masaki Hashimoto, Takuya Seki, Asuka Takumi
Publikováno v:
Toxicology Reports, Vol 7, Iss, Pp 1233-1241 (2020)
Wolffia is a genus of protein-rich aquatic plants. Mankai, a cultivated strain of Wolffia globosa, contains more than 40 % protein based on dry matter evaluation. Furthermore, Mankai is nutritionally excellent as a food material, and is expected to b
Publikováno v:
Regulatory Toxicology and Pharmacology. 103:345-351
Two studies were conducted to further assess its mutagenic and genotoxic potential. In a bacterial reverse mutation pre-incubation study, Salmonella typhimurium strains TA100, TA1535, TA98, and TA1537 and Escherichia coli WP2 uvrA were treated with a
Publikováno v:
The Journal of toxicological sciences. 45(10)
To assess the influences of blood sampling volumes or sites on toxicological and toxicokinetic (TK) evaluations, 4-week duration animal studies and a single-dose TK study of imipramine were conducted. In the toxicological evaluation, six-week-old Spr
Publikováno v:
Regulatory Toxicology and Pharmacology. 107:104399
In response to the lack of authenticated mutagenicity/genotoxicity studies on MSG monohydrate, a series of genotoxicity studies conducted under GLP and according to globally accepted test guidelines (e.g., OECD) was performed. A bacterial reverse mut
Publikováno v:
Microbiology. 155:541-550
Indole is produced by tryptophanase during growth of enteric bacteria and accumulates in the culture medium. The physiological role of indole production is poorly understood. We discovered that enterohaemorrhagic Escherichia coli (EHEC) O157 : H7 wit