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Prediction of permeability across intestinal cell monolayers for 219 disparate chemicals using in vitro experimental coefficients in a pH gradient system and in silico analyses by trivariate linear regressions and machine learning

Autor: Riku Hayasaka, Junya Ohori, Hiroshi Yamazaki, Kimito Funatsu, Izumi Sano, Masato Kitajima, Rie Saito, Fumiaki Shono, Yusuke Kamiya, Asuka Omura, Kentaro Handa

Publikováno v: Biochemical pharmacology. 192

For medicines, the apparent membrane permeability coefficients (Papp) across human colorectal carcinoma cell line (Caco-2) monolayers under a pH gradient generally correlate with the fraction absorbed after oral intake. Furthermore, the in vitro Papp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9538ccf97b757a1ec9f2a9c0679d18b3
https://pubmed.ncbi.nlm.nih.gov/34461115

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