Zobrazeno 1 - 10
of 726
pro vyhledávání: '"Asuka Inoue"'
Autor:
Sazanami Mori, Natsuki Nakamura, Ayane Fuchigami, Satoshi Yoshimoto, Moe Sakakibara, Toshiyuki Ozawa, Junken Aoki, Asuka Inoue, Hayakazu Sumida, Hideya Ando, Motonao Nakamura
Publikováno v:
FASEB BioAdvances, Vol 6, Iss 10, Pp 424-441 (2024)
Abstract Bitter taste receptors (TAS2Rs) are not only expressed in the oral cavity but also in skin. Extraoral TAS2Rs are thought to be involved in non‐taste perception and tissue‐specific functions. Keratinocytes that express TAS2Rs in the skin
Externí odkaz:
https://doaj.org/article/87f2088083af4c1389595ee070e7630c
Autor:
Julian Brands, Sergi Bravo, Lars Jürgenliemke, Lukas Grätz, Hannes Schihada, Fabian Frechen, Judith Alenfelder, Cy Pfeil, Paul Georg Ohse, Suzune Hiratsuka, Kouki Kawakami, Luna C. Schmacke, Nina Heycke, Asuka Inoue, Gabriele König, Alexander Pfeifer, Dagmar Wachten, Gunnar Schulte, Torsten Steinmetzer, Val J. Watts, Jesús Gomeza, Katharina Simon, Evi Kostenis
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-21 (2024)
Abstract A long-held tenet in inositol-lipid signaling is that cleavage of membrane phosphoinositides by phospholipase Cβ (PLCβ) isozymes to increase cytosolic Ca2+ in living cells is exclusive to Gq- and Gi-sensitive G protein-coupled receptors (G
Externí odkaz:
https://doaj.org/article/be62b1c248c547b084b1b6712cdf03af
Autor:
Alexei Sirbu, Marc Bathe-Peters, Jothi L. M. Kumar, Asuka Inoue, Martin J. Lohse, Paolo Annibale
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract G protein-coupled receptors’ conformational landscape can be affected by their local, microscopic interactions within the cell plasma membrane. We employ here a pleiotropic stimulus, namely osmotic swelling, to alter the cortical environme
Externí odkaz:
https://doaj.org/article/3d10c535208545268b1e907a986a1d80
Autor:
Aika Iwama, Ryoji Kise, Hiroaki Akasaka, Fumiya K. Sano, Hidetaka S. Oshima, Asuka Inoue, Wataru Shihoya, Osamu Nureki
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Pyroglutamylated RF-amide peptide (QRFP) is a peptide hormone with a C-terminal RF-amide motif. QRFP selectively activates a class A G-protein-coupled receptor (GPCR) GPR103 to exert various physiological functions such as energy metabolism
Externí odkaz:
https://doaj.org/article/b6422e77482146409dd13929fed4321c
Autor:
Manae Tatsumi, Christian Cruz, Nozomi Kamakura, Riku Kuwabara, Gaku Nakamura, Tatsuya Ikuta, Ravinder Abrol, Asuka Inoue
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract G-protein-coupled receptors (GPCRs) transduce diverse signals into the cell by coupling to one or several Gα subtypes. Of the 16 Gα subtypes in human cells, Gα12 and Gα13 belong to the G12 subfamily and are reported to be functionally di
Externí odkaz:
https://doaj.org/article/ea2e846a28764393a220c1f4ee76a980
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-9 (2024)
Abstract Arginine–vasopressin (AVP), a cyclic peptide hormone composed of nine amino acids, regulates water reabsorption by increasing intracellular cyclic adenosine monophosphate (cAMP) concentrations via the vasopressin V2 receptor (V2R). Plasma
Externí odkaz:
https://doaj.org/article/fa7be071dce5412cb614f2d63e994bc9
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-14 (2024)
Abstract Muscarinic acetylcholine receptor M3 (M3) and its downstream effector Gq/11 are critical drug development targets due to their involvement in physiopathological processes. Although the structure of the M3-miniGq complex was recently publishe
Externí odkaz:
https://doaj.org/article/ebcad8a151474d7a8d09eb8053bb6323
Autor:
András Dávid Tóth, Eszter Soltész-Katona, Katalin Kis, Viktor Guti, Sharon Gilzer, Susanne Prokop, Roxána Boros, Ádám Misák, András Balla, Péter Várnai, Lilla Turiák, András Ács, László Drahos, Asuka Inoue, László Hunyady, Gábor Turu
Publikováno v:
Cell Reports, Vol 43, Iss 5, Pp 114241- (2024)
Summary: The binding and function of β-arrestins are regulated by specific phosphorylation motifs present in G protein-coupled receptors (GPCRs). However, the exact arrangement of phosphorylated amino acids responsible for establishing a stable inte
Externí odkaz:
https://doaj.org/article/d4a48bb17a7244b4b51ee21e0f338741
Autor:
Jae-Hyun Park, Kouki Kawakami, Naito Ishimoto, Tatsuya Ikuta, Mio Ohki, Toru Ekimoto, Mitsunori Ikeguchi, Dong-Sun Lee, Young-Ho Lee, Jeremy R. H. Tame, Asuka Inoue, Sam-Yong Park
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract Hydroxycarboxylic acid receptors (HCAR1, HCAR2, and HCAR3) transduce Gi/o signaling upon biding to molecules such as lactic acid, butyric acid and 3-hydroxyoctanoic acid, which are associated with lipolytic and atherogenic activity, and neur
Externí odkaz:
https://doaj.org/article/9d0cff241b9740af812262f36628e703
Autor:
Evi Kostenis, Jesus Gomeza, Elke Miess-Tanneberg, Nina Kathleen Blum, Tobias Benkel, Andy Chevigné, Carsten Hoffmann, Peter Kolb, Viacheslav Nikolaev, Maria Waldhoer, Martyna Szpakowska, Asuka Inoue, Stefan Schulz
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-3 (2023)
Externí odkaz:
https://doaj.org/article/f7f2be86b45849a48e332136b0364eaf