A proliferation‐inducing ligand–mediated anti‐inflammatory response of astrocytes in multiple sclerosis

Autor: Mahdia Benkhoucha, Mashal Claude Ahmed, Dominique Baeten, Romain Marignier, Jose Boucraut, Olivier Casez, Michael Hahne, Jean Boutonnat, Corinne Sonrier, Benoit Manfroi, Laurie Baert, Patrice N. Marche, Nathalie Sturm, Marine Tessier, Patrice H. Lalive, Romain R. Vivès, Bertrand Huard, Cyril Rivat, Catherine Ghezzi, Hans Lassmann, Pascal Schneider, Natalia Popa, Gilda Raguenez, Alexis Broisat, Hugues Lortat-Jacob, Mitra Ahmadi

Publikováno v: Annals of Neurology
Annals of Neurology, Wiley, 2019, 85 (3), pp.406-420. ⟨10.1002/ana.25415⟩
Annals of neurology, vol. 85, no. 3, pp. 406-420
Annals of neurology, 85(3), 406-420. John Wiley and Sons Inc.
Annals of Neurology, 2019, 85 (3), pp.406-420. ⟨10.1002/ana.25415⟩

International audience; OBJECTIVE:The two related tumor necrosis factor members a proliferation-inducing ligand (APRIL) and B-cell activation factor (BAFF) are currently targeted in autoimmune diseases as B-cell regulators. In multiple sclerosis (MS)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64212102082e58fcca9193ce04f096a3
https://www.hal.inserm.fr/inserm-02332844

Neuroinflammation in Alzheimer's disease

Autor: Koji Yamanaka, Jari Koistinaho, Douglas T. Golenbock, Terrence Town, Guy C. Brown, Erik Boddeke, Monica J. Carson, V. Hugh Perry, Gabor C. Petzold, Olga Garaschuk, David J. Brooks, Markus P. Kummer, John C.S. Breitner, Nikolaus Deigendesch, Frederic Brosseron, Greg M. Cole, Nicolas G. Bazan, Stéphane Hunot, Michael T. Heneka, Dave Morgan, Javier Vitorica, Gary E. Landreth, Clive Holmes, Eicke Latz, Bertrand Joseph, Annett Halle, Charles A. Dinarello, Mari L. Shinohara, Joseph El Khoury, Douglas L. Feinstein, Andreas H. Jacobs, Tony Wyss-Coray, Alexei Verkhratsky, Karl Herrup, Richard M. Ransohoff, Sally A. Frautschy, Bente Finsen

Publikováno v: The Lancet. Neurology, vol 14, iss 4
ResearcherID
The lancet / Neurology 14(4), 388-405 (2015). doi:10.1016/S1474-4422(15)70016-5
Lancet Neurology, 14, 388-405
Heneka, MT; Carson, MJ; Khoury, JE; Landreth, GE; Brosseron, F; Feinstein, DL; et al.(2015). Neuroinflammation in Alzheimer's disease. The Lancet Neurology, 14(4), 388-405. doi: 10.1016/S1474-4422(15)70016-5. UCLA: Retrieved from: http://www.escholarship.org/uc/item/99h2f9m1
Lancet Neurology, 14, 4, pp. 388-405
Heneka, M T, Carson, M J, Khoury, J E, Landreth, G E, Brosseron, F, Feinstein, D L, Jacobs, A H, Wyss-Coray, T, Vitorica, J, Ransohoff, R M, Herrup, K, Frautschy, S A, Finsen, B, Brown, G C, Verkhratsky, A, Yamanaka, K, Koistinaho, J, Latz, E, Halle, A, Petzold, G C, Town, T, Morgan, D, Shinohara, M L, Perry, V H, Holmes, C, Bazan, N G, Brooks, D J, Hunot, S, Joseph, B, Deigendesch, N, Garaschuk, O, Boddeke, E, Dinarello, C A, Breitner, J C, Cole, G M, Golenbock, D T & Kummer, M P 2015, ' Neuroinflammation in Alzheimer's disease ', Lancet Neurology, vol. 14, no. 4, pp. 388-405 . https://doi.org/10.1016/S1474-4422(15)70016-5
The Lancet Neurology

Increasing evidence suggests that Alzheimer's disease pathogenesis is not restricted to the neuronal compartment but strongly interacts with immunological mechanisms in the brain. Misfolded and aggregated proteins bind to pattern recognition receptor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2286134b7cbed70b5343d6eb0d1252b3
https://escholarship.org/uc/item/99h2f9m1

Are astrocytes central players in the pathophysiology of multiple sclerosis?

Autor: Jacques De Keyser, Esther Zeinstra, Elliot M. Frohman

Publikováno v: Archives of Neurology, 60(1), 132-136. AMER MEDICAL ASSOC

An interaction between antimyelin T cells and antigen-presenting glial cells is a crucial step in the cascade of immune events that lead to the inflammatory lesions in multiple sclerosis (MS). One of the most debated and controversial issues is wheth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f21947b650715ced9f9b48686fc5fe93
https://pubmed.ncbi.nlm.nih.gov/12533101

TWEAK is expressed by glial cells, induces astrocyte proliferation and increases EAE severity

Autor: José Boucraut, Shozo Izui, Michel Khrestchatisky, Simone Varriale, Dominique Bernard, Sophie Desplat-Jego, Rafik Terra, Yves Chicheportiche, Rita Creidy

Publikováno v: Journal of Neuroimmunology, Vol. 133, No 1-2 (2002) pp. 116-123

TWEAK is a new TNF family member with proinflammatory and proliferative effects on different cell types, mediated by the recently identified Fn14 receptor. TWEAK expression was analyzed on mouse microglial cells and astrocytes. Both cell types expres

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19272d3f80728187949989aac9e8bd58
https://pubmed.ncbi.nlm.nih.gov/12446014

Transcription factor NF-kappa B is activated in microglia during experimental autoimmune encephalomyelitis

Autor: Kaltschmidt, Christian, Kaltschmidt, Barbara, Lannes-Vieira, J., Kreutzberg, G. W., Wekerle, H., Baeuerle, P. A., Gehrmann, J.

NF-kappa B is an inducible transcription factor involved in the induction of multiple genes during inflammatory processes. So far the information pertaining to the role of NF-kappa B in autoimmune processes has been restricted to in vitro analysis. T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2294::1c7102350edcedd46d1dbdc4fedd9db6
https://pub.uni-bielefeld.de/record/2398807