Association between inflammation, reward processing, and ibuprofen-induced increases of miR-23b in astrocyte-enriched extracellular vesicles: A randomized, placebo-controlled, double-blind, exploratory trial in healthy individuals

Autor: Kaiping Burrows, Leandra K. Figueroa-Hall, Ahlam M. Alarbi, Jennifer L. Stewart, Rayus Kuplicki, Chibing Tan, Bethany N. Hannafon, Rajagopal Ramesh, Jonathan Savitz, Sahib Khalsa, T. Kent Teague, Victoria B. Risbrough, Martin P. Paulus

Publikováno v: Brain, Behavior, & Immunity - Health, Vol 27, Iss , Pp 100582- (2023)

Ibuprofen, a non-steroidal, anti-inflammatory drug, modulates inflammation but may also have neuroprotective effects on brain health that are poorly understood. Astrocyte-enriched extracellular vesicles (AEEVs) facilitate cell-to-cell communication a

Externí odkaz: https://doaj.org/article/dcdb4d2cb0d4484ba0f32947d3962cc2

Association between inflammation, reward processing, and ibuprofen-induced increases of miR-23b in astrocyte-enriched extracellular vesicles: A randomized, placebo-controlled, double-blind, exploratory trial in healthy individuals.

Autor: Burrows K; Laureate Institute for Brain Research, Tulsa, OK, USA., Figueroa-Hall LK; Laureate Institute for Brain Research, Tulsa, OK, USA., Alarbi AM; Departments of Surgery and Psychiatry, School of Community Medicine, The University of Oklahoma, Tulsa, OK, USA.; Integrative Immunology Center, School of Community Medicine, The University of Oklahoma, Tulsa, OK, USA., Stewart JL; Laureate Institute for Brain Research, Tulsa, OK, USA.; Department of Community Medicine, The University of Tulsa, Tulsa, OK, USA., Kuplicki R; Laureate Institute for Brain Research, Tulsa, OK, USA., Tan C; Integrative Immunology Center, School of Community Medicine, The University of Oklahoma, Tulsa, OK, USA., Hannafon BN; Department of Obstetrics & Gynecology, The University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA., Ramesh R; Department of Pathology, The University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA., Savitz J; Laureate Institute for Brain Research, Tulsa, OK, USA.; Department of Community Medicine, The University of Tulsa, Tulsa, OK, USA., Khalsa S; Laureate Institute for Brain Research, Tulsa, OK, USA.; Department of Community Medicine, The University of Tulsa, Tulsa, OK, USA., Teague TK; Departments of Surgery and Psychiatry, School of Community Medicine, The University of Oklahoma, Tulsa, OK, USA.; Department of Biochemistry and Microbiology, The Oklahoma State University Center for Health Sciences, Tulsa, OK, USA.; Department of Pharmaceutical Sciences, The University of Oklahoma College of Pharmacy, Oklahoma City, OK, USA., Risbrough VB; Center of Excellence for Stress and Mental Health, La Jolla, CA, USA.; Department of Psychiatry, University of California, San Diego, La Jolla, CA, USA., Paulus MP; Laureate Institute for Brain Research, Tulsa, OK, USA.; Department of Community Medicine, The University of Tulsa, Tulsa, OK, USA.

Publikováno v: Brain, behavior, & immunity - health [Brain Behav Immun Health] 2022 Dec 24; Vol. 27, pp. 100582. Date of Electronic Publication: 2022 Dec 24 (Print Publication: 2023).