Zobrazeno 1 - 10
of 71
pro vyhledávání: '"Astrid Wietelmann"'
Autor:
Maaike Hachenberger, Tobias Braun, Stefan T. Gerner, Laura Suenner, Anne Schänzer, Martin Juenemann, Clemens Mueller, Astrid Wietelmann, Erwin Stolz, Markus Schoenburg, Marlene Tschernatsch, Tibo Gerriets, Hagen B. Huttner, Mesut Yeniguen
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract Using ferric chloride (FeCl3) to induce experimental superior sagittal sinus (SSS) thrombosis might interfere with magnetic resonance imaging (MRI)-assisted visualization and evaluation of the thrombus, the brain parenchyma, and the quality
Externí odkaz:
https://doaj.org/article/e7c0115fae1b4a4e8b97aab15402e402
Endothelial FAT1 inhibits angiogenesis by controlling YAP/TAZ protein degradation via E3 ligase MIB2
Autor:
Rui Li, Jingchen Shao, Young-June Jin, Haruya Kawase, Yu Ting Ong, Kerstin Troidl, Qi Quan, Lei Wang, Remy Bonnavion, Astrid Wietelmann, Francoise Helmbacher, Michael Potente, Johannes Graumann, Nina Wettschureck, Stefan Offermanns
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
The authors report that endothelial protocadherin FAT1 inhibits endothelial proliferation and angiogenesis by promoting degradation of the transcriptional cofactors YAP and TAZ by direct interaction with the E3 ubiquitin ligase Mind Bomb-2 (MIB2).
Externí odkaz:
https://doaj.org/article/ae8cf225971e49d0b6bc0f0653d4b7c5
Autor:
D. Julia Trembinski, Diewertje I. Bink, Kosta Theodorou, Janina Sommer, Ariane Fischer, Anke van Bergen, Chao-Chung Kuo, Ivan G. Costa, Christoph Schürmann, Matthias S. Leisegang, Ralf P. Brandes, Tijna Alekseeva, Boris Brill, Astrid Wietelmann, Christopher N. Johnson, Alexander Spring-Connell, Manuel Kaulich, Stanislas Werfel, Stefan Engelhardt, Marc N. Hirt, Kaja Yorgan, Thomas Eschenhagen, Luisa Kirchhof, Patrick Hofmann, Nicolas Jaé, Ilka Wittig, Nazha Hamdani, Corinne Bischof, Jaya Krishnan, Riekelt H. Houtkooper, Stefanie Dimmeler, Reinier A. Boon
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Aging induces cardiovascular disease, but which RNA molecules control cardiac aging is poorly understood. Here the authors identified the aging-regulated non-coding RNA Sarrah, which controls cardiomyocyte survival and cardiac function by inducing ca
Externí odkaz:
https://doaj.org/article/7441973a82494a94a2d3de6efa08b38c
Autor:
Mengnan Li, Shin-ya Nishio, Chie Naruse, Meghan Riddell, Sabrina Sapski, Tatsuya Katsuno, Takao Hikita, Fatemeh Mizapourshafiyi, Fiona M. Smith, Leanne T. Cooper, Min Goo Lee, Masahide Asano, Thomas Boettger, Marcus Krueger, Astrid Wietelmann, Johannes Graumann, Bryan W. Day, Andrew W. Boyd, Stefan Offermanns, Shin-ichiro Kitajiri, Shin-ichi Usami, Masanori Nakayama
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
While biallelic mutations of the SLC26A4 gene cause non-syndromic hearing loss with enlarged vestibular aqueducts or Pendred syndrome, a considerable number of patients carry mono-allelic mutations. Here the authors identify EPHA2 as another causativ
Externí odkaz:
https://doaj.org/article/2394b397faac4471be86a22fa110d8db
Autor:
Swati Dabral, Christian Muecke, Chanil Valasarajan, Mario Schmoranzer, Astrid Wietelmann, Gregg L. Semenza, Michael Meister, Thomas Muley, Tamina Seeger-Nukpezah, Christos Samakovlis, Norbert Weissmann, Friedrich Grimminger, Werner Seeger, Rajkumar Savai, Soni S. Pullamsetti
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-18 (2019)
Pulmonary hypertension is characterized by a metabolic switch similar to the Warburg effect in cancer. Here Dabral et al. describe a RASSF1a-HIF-1α feedforward loop driving the Warburg effect both in a mouse model of hypoxia-induced pulmonary hypert
Externí odkaz:
https://doaj.org/article/a8901cfbf7474186b10f84b921b3e98d
Autor:
Holger Lörchner, Juan M. Adrian-Segarra, Christian Waechter, Roxanne Wagner, Maria Elisa Góes, Nathalie Brachmann, Krishnamoorthy Sreenivasan, Astrid Wietelmann, Stefan Günther, Nicolas Doll, Thomas Braun, Jochen Pöling
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 1, p 353 (2021)
Oncostatin M (OSM) and leukemia inhibitory factor (LIF) signaling protects the heart after myocardial infarction (MI). In mice, oncostatin M receptor (OSMR) and leukemia inhibitory factor receptor (LIFR) are selectively activated by the respective co
Externí odkaz:
https://doaj.org/article/266698484bd3449397ba50735e98a7fd
Autor:
Marten Szibor, Praveen K. Dhandapani, Eric Dufour, Kira M. Holmström, Yuan Zhuang, Isabelle Salwig, Ilka Wittig, Juliana Heidler, Zemfira Gizatullina, Timur Gainutdinov, German Mouse Clinic Consortium, Helmut Fuchs, Valérie Gailus-Durner, Martin Hrabě de Angelis, Jatin Nandania, Vidya Velagapudi, Astrid Wietelmann, Pierre Rustin, Frank N. Gellerich, Howard T. Jacobs, Thomas Braun
Publikováno v:
Disease Models & Mechanisms, Vol 10, Iss 2, Pp 163-171 (2017)
Plants and many lower organisms, but not mammals, express alternative oxidases (AOXs) that branch the mitochondrial respiratory chain, transferring electrons directly from ubiquinol to oxygen without proton pumping. Thus, they maintain electron flow
Externí odkaz:
https://doaj.org/article/723f62cecb1f4bc78341cbec0e109669
Autor:
Ramesh Chennupati, Angela Wirth, Julie Favre, Rui Li, Rémy Bonnavion, Young-June Jin, Astrid Wietelmann, Frank Schweda, Nina Wettschureck, Daniel Henrion, Stefan Offermanns
Publikováno v:
eLife, Vol 8 (2019)
Myogenic vasoconstriction is an autoregulatory function of small arteries. Recently, G-protein-coupled receptors have been involved in myogenic vasoconstriction, but the downstream signalling mechanisms and the in-vivo-function of this myogenic autor
Externí odkaz:
https://doaj.org/article/bfbbce460cf24c5d9cfddef654722638
Autor:
Shun Lu, Shuya Liu, Astrid Wietelmann, Baktybek Kojonazarov, Ann Atzberger, Cong Tang, Ralph Theo Schermuly, Hermann-Josef Gröne, Stefan Offermanns
Publikováno v:
PLoS ONE, Vol 12, Iss 8, p e0183166 (2017)
GPR116 (ADGRF5) and ELTD1 (ADGRL4) belong to different subfamilies of the adhesion G-protein-coupled receptor group but are both expressed in endothelial cells. We therefore analyzed their functions in mice lacking these receptors. While loss of GPR1
Externí odkaz:
https://doaj.org/article/e8e326545b03427e8fba2dba3f7837c8
Autor:
Jedrzej Hoffmann, Manuel Ospelt, Christian Troidl, Sandra Voss, Christoph Liebetrau, Won-Keun Kim, Andreas Rolf, Astrid Wietelmann, Thomas Braun, Kerstin Troidl, Sakthivel Sadayappan, David Barefield, Christian Hamm, Holger Nef, Helge Möllmann
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e98456 (2014)
AimsMouse models of myocardial infarction (MI) are commonly used to explore the pathophysiological role of the monocytic response in myocardial injury and to develop translational strategies. However, no study thus far has examined the potential impa
Externí odkaz:
https://doaj.org/article/b1cd146186c84252aa1ee6581efc1812