Zobrazeno 1 - 10
of 75
pro vyhledávání: '"Astrid Weins"'
Autor:
Ayshwarya Subramanian, Katherine A. Vernon, Yiming Zhou, Jamie L. Marshall, Maria Alimova, Carlos Arevalo, Fan Zhang, Michal Slyper, Julia Waldman, Monica S. Montesinos, Danielle Dionne, Lan T. Nguyen, Michael S. Cuoco, Dan Dubinsky, Jason Purnell, Keith Keller, Samuel H. Sturner, Elizabeth Grinkevich, Ayan Ghoshal, Amanda Kotek, Giorgio Trivioli, Nathan Richoz, Mary B. Humphrey, Isabella G. Darby, Sarah J. Miller, Yingping Xu, Astrid Weins, Alexandra Chloe-Villani, Steven L. Chang, Matthias Kretzler, Orit Rosenblatt-Rosen, Jillian L. Shaw, Kurt A. Zimmerman, Menna R. Clatworthy, Aviv Regev, Anna Greka
Publikováno v:
Cell Reports, Vol 43, Iss 6, Pp 114253- (2024)
Summary: Diabetic kidney disease (DKD), the most common cause of kidney failure, is a frequent complication of diabetes and obesity, and yet to date, treatments to halt its progression are lacking. We analyze kidney single-cell transcriptomic profile
Externí odkaz:
https://doaj.org/article/c26ba69a6afe47bdbc7deb8408bb9ad1
Autor:
Garrett S. Dunlap, Daniel DiToro, Joel Henderson, Sujal I. Shah, Mike Manos, Mariano Severgnini, Astrid Weins, Indira Guleria, Patrick A. Ott, Naoka Murakami, Deepak A. Rao
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-8 (2023)
Immune checkpoint inhibitors (ICI) may have unanticipated side effects in transplant recipients who subsequently develop tumors. Here the authors used single-cell sequencing to identify and characterize allogeneic reactive T cells that developed afte
Externí odkaz:
https://doaj.org/article/e991277fef0d4954afa3894a6cef86f7
Autor:
Ahmad Halawi, Abdullah B. El Kurdi, Katherine A. Vernon, Zhabiz Solhjou, John Y. Choi, Anis J. Saad, Nour K. Younis, Rania Elfekih, Mostafa Tawfeek Mohammed, Christa A. Deban, Astrid Weins, Reza Abdi, Leonardo V. Riella, Sasha A. De Serres, Paolo Cravedi, Anna Greka, Pierre Khoueiry, Jamil R. Azzi
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
BackgroundKidney transplant recipients are currently treated with nonspecific immunosuppressants that cause severe systemic side effects. Current immunosuppressants were developed based on their effect on T-cell activation rather than the underlying
Externí odkaz:
https://doaj.org/article/06800a222d9a45f781483d981d3fc496
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Primary focal segmental glomerulosclerosis (FSGS), typically characterized by diffuse podocyte foot process effacement and nephrotic syndrome (diffuse podocytopathy), is generally attributed to a circulating permeability factor. Primary FSGS can recu
Externí odkaz:
https://doaj.org/article/af8d10c516a44bf899ff1e287888cc6c
Autor:
Sarah E. Nystrom, Guojie Li, Somenath Datta, Karen L. Soldano, Daniel Silas, Astrid Weins, Gentzon Hall, David B. Thomas, Opeyemi A. Olabisi
Publikováno v:
JCI Insight, Vol 7, Iss 11 (2022)
COVID-19 infection causes collapse of glomerular capillaries and loss of podocytes, culminating in a severe kidney disease called COVID-19–associated nephropathy (COVAN). The underlying mechanism of COVAN is unknown. We hypothesized that cytokines
Externí odkaz:
https://doaj.org/article/80314d153ef540f08012cd60a5808a21
Autor:
Jamie L. Marshall, Teia Noel, Qingbo S. Wang, Haiqi Chen, Evan Murray, Ayshwarya Subramanian, Katherine A. Vernon, Silvana Bazua-Valenti, Katie Liguori, Keith Keller, Robert R. Stickels, Breanna McBean, Rowan M. Heneghan, Astrid Weins, Evan Z. Macosko, Fei Chen, Anna Greka
Publikováno v:
iScience, Vol 25, Iss 4, Pp 104097- (2022)
Summary: High-resolution spatial transcriptomics enables mapping of RNA expression directly from intact tissue sections; however, its utility for the elucidation of disease processes and therapeutically actionable pathways remains unexplored. We appl
Externí odkaz:
https://doaj.org/article/d6f6c8d314e2467b847da7b75df23eaa
Autor:
Sharifa Sahai, Richard J. Chen, Jana Lipkova, Kuan Chen, Tiffany Y. Chen, Drew Williamson, Judy J. Wang, Astrid Weins, Faisal Mahmood
Publikováno v:
Journal of Pathology Informatics, Vol 13, Iss , Pp 100059- (2022)
Externí odkaz:
https://doaj.org/article/6627250b995d4780804de928d8ee8bbd
Publikováno v:
Brazilian Journal of Nephrology, Vol 42, Iss 1, Pp 99-105 (2019)
Externí odkaz:
https://doaj.org/article/66c16ab469654281b88327ead3e9e3e2
Autor:
Ayshwarya Subramanian, Eriene-Heidi Sidhom, Maheswarareddy Emani, Katherine Vernon, Nareh Sahakian, Yiming Zhou, Maria Kost-Alimova, Michal Slyper, Julia Waldman, Danielle Dionne, Lan T. Nguyen, Astrid Weins, Jamie L. Marshall, Orit Rosenblatt-Rosen, Aviv Regev, Anna Greka
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
How reproducible human kidney organoids derived from different iPSC lines are, and how faithful they are to human kidney tissue remain unclear. Here, the authors use four human iPSC lines to derive kidney organoids and show how organoid composition i
Externí odkaz:
https://doaj.org/article/fec9d1d79cc3436c8e6951c9b267d13d
Autor:
Yiming Zhou, Choah Kim, Juan Lorenzo B. Pablo, Fan Zhang, Ji Yong Jung, Li Xiao, Silvana Bazua-Valenti, Maheswarareddy Emani, Corey R. Hopkins, Astrid Weins, Anna Greka
Publikováno v:
Frontiers in Medicine, Vol 8 (2021)
Podocyte injury and the appearance of proteinuria are key features of several progressive kidney diseases. Genetic deletion or selective inhibition of TRPC5 channels with small-molecule inhibitors protects podocytes in rodent models of kidney disease
Externí odkaz:
https://doaj.org/article/63a32a6e578a4a1fb96f6f3d356e4283